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Biology and Biochemistry

D-Index
116
Citations
58351
World Ranking
745
National Ranking
472

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

David M. Ornitz is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on subfields such as Molecular Biology, Pulmonary and Respiratory Medicine, Surgery, Genetics, and Cell Biology.

The scientist's work concentrates on several key topics, including:

  • Fibroblast Growth Factor Research
  • Congenital Diaphragmatic Hernia Studies
  • Neonatal Respiratory Health Research
  • Connective Tissue Disorders Research
  • Kruppel-like Factors Research
  • Tendon Structure and Treatment
  • Pulmonary Hypertension Research and Treatments

David M. Ornitz has contributed to multiple publications, with notable recent papers consisting of:

  • "New developments in the biology of fibroblast growth factors," 2022, published in WIREs Mechanisms of Disease
  • "VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway," 2023, published in Signal Transduction and Targeted Therapy
  • "FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching," 2020, published in Science Signaling
  • "Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer," 2021, published in Cancer Research
  • "Endothelial FGF signaling is protective in hypoxia-induced pulmonary hypertension," 2021, published in Journal of Clinical Investigation

The majority of their publications appear in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Developmental Dynamics
  • Development
  • Journal of Clinical Investigation
  • Zenodo (CERN European Organization for Nuclear Research)

Frequent collaborators include Yongjun Yin, Debabrata Patra, Connor C. Leek, Elahe Ganji, and Megan L. Killian, reflecting ongoing cooperative research efforts.

In recognition of their scientific contributions, David M. Ornitz was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2019.

Best Publications

  • Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.

    Avner Yayon;Michael Klagsbrun;Jeffrey D. Esko;Philip Leder

  • Fibroblast growth factors

    David M Ornitz;Nobuyuki Itoh

  • Receptor specificity of the fibroblast growth factor family.

    David M. Ornitz;Jingsong Xu;Jennifer S. Colvin;Donald G. McEwen

  • The Fibroblast Growth Factor signaling pathway

    David M. Ornitz;Nobuyuki Itoh

  • Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

    Xiuqin Zhang;Omar A. Ibrahimi;Shaun K. Olsen;Hisashi Umemori

  • Evolution of the Fgf and Fgfr gene families

    Nobuyuki Itoh;David M. Ornitz

  • Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

    Ramaswamy Govindan;Li Ding;Malachi Griffith;Janakiraman Subramanian

  • FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease.

    David M. Ornitz;Pierre J. Marie

  • FGFs, heparan sulfate and FGFRs: complex interactions essential for development

    David M. Ornitz

  • Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

    Jennifer S. Colvin;Barbara A. Bohne;Gary W. Harding;Donald G. McEwen

  • Murine FGFR-1 is required for early postimplantation growth and axial organization.

    C X Deng;A Wynshaw-Boris;M M Shen;C Daugherty

  • Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

    D M Ornitz;A Yayon;J G Flanagan;C M Svahn

  • Sequential roles of Hedgehog and Wnt signaling in osteoblast development

    Hongliang Hu;Matthew J. Hilton;Xiaolin Tu;Kai Yu

  • Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease

    Nobuyuki Itoh;David M. Ornitz

  • A Twist Code Determines the Onset of Osteoblast Differentiation

    Peter Bialek;Britt Kern;Xiangli Yang;Marijke Schrock

  • Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart.

    Kory J. Lavine;Slava Epelman;Keita Uchida;Kassandra J. Weber

  • Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

    Kai Yu;Jingsong Xu;Zhonghao Liu;Drazen Sosic

  • Male-to-Female Sex Reversal in Mice Lacking Fibroblast Growth Factor 9

    Jennifer S. Colvin;Rebecca P. Green;Jennifer Schmahl;Blanche Capel

  • Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.

    Xiaoling Xu;Michael Weinstein;Cuiling Li;Michael Naski

  • Unique Expression Pattern of the FGF Receptor 3 Gene during Mouse Organogenesis

    Kevin Peters;David Ornitz;Sabine Werner;Lewis Williams

Frequent Co-Authors

Philip Leder
Philip Leder Harvard University
Jeanne M. Nerbonne
Jeanne M. Nerbonne Washington University in St. Louis
Ralph L. Brinster
Ralph L. Brinster University of Pennsylvania
Fanxin Long
Fanxin Long Children's Hospital of Philadelphia
Mark E. Warchol
Mark E. Warchol Washington University in St. Louis
Richard D. Palmiter
Richard D. Palmiter University of Washington
Gabriel Waksman
Gabriel Waksman University College London
Nobuyuki Itoh
Nobuyuki Itoh Kyoto University
Juha Partanen
Juha Partanen University of Helsinki
Moosa Mohammadi
Moosa Mohammadi New York University Langone Medical Center

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