2026 Paul S. Knoepfler: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	49	2633	2383	1286	1153	103	9079

Overview

Paul S. Knoepfler is affiliated with the University of California, Davis in the United States. Their research spans multiple fields with a strong focus on biochemistry, genetics, and molecular biology. Their body of work intersects significantly with medicine, encompassing areas such as molecular biology, genetics, physiology, rheumatology, and immunology.

Their research topics include glioma diagnosis and treatment, genomics and chromatin dynamics, epigenetics and DNA methylation, CRISPR and genetic engineering, RNA regulation and disease, genetics and neurodevelopmental disorders, and nuclear structure and function.

Notable recent publications include:

Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling (2020, Communications Biology)
Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG (2022, Epigenetics & Chromatin)
Knockout tales: the versatile roles of histone H3.3 in development and disease (2023, Epigenetics & Chromatin)
DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer (2021, Stem Cell Reports)
Noncanonical function of folate through folate receptor 1 during neural tube formation (2024, Nature Communications)

Their frequent coauthors are:

Rachel Herndon Klein
Nichole Lewis
Jennifer Yee
Kelly Bush
Vanessa Cervantes

They have published regularly in these scientific venues:

Epigenetics & Chromatin
Communications Biology
Stem Cell Reports
Nature Communications
Frontiers in Cell and Developmental Biology

Paul S. Knoepfler's work covers a range of critical topics in genetics and molecular biology, with an emphasis on epigenetic regulation mechanisms and their implications in cancer and neurodevelopmental disorders. Their research draws from and contributes to an interdisciplinary landscape combining molecular biology techniques with clinical insights.

Best Publications

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.

Paul S. Knoepfler;Pei Feng Cheng;Robert N. Eisenman

627
Citations
Deconstructing Stem Cell Tumorigenicity: A Roadmap to Safe Regenerative Medicine

Paul S. Knoepfler;Paul S. Knoepfler

560
Citations
Sin meets NuRD and other tails of repression

Paul S Knoepfler;Robert N Eisenman

490
Citations
Myc influences global chromatin structure.

Paul S Knoepfler;Xiao Yong Zhang;Pei Feng Cheng;Philip R. Gafken

462
Citations
Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential.

Charlotte A Berkes;Donald A Bergstrom;Donald A Bergstrom;Bennett H Penn;Karen J Seaver

372
Citations
Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

Elisa Laurenti;Barbara Varnum-Finney;Anne Wilson;Isabel Ferrero

371
Citations
Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry

Leigh Turner;Paul S Knoepfler;Paul S Knoepfler

353
Citations
Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation.

Tadashi Okubo;Paul S. Knoepfler;Robert N. Eisenman;Brigid L. M. Hogan

270
Citations
Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

Paul S. Knoepfler;Katherine R. Calvo;Haiming Chen;Stylianos E. Antonarakis

246
Citations
THE PENTAPEPTIDE MOTIF OF HOX PROTEINS IS REQUIRED FOR COOPERATIVE DNA BINDING WITH PBX1, PHYSICALLY CONTACTS PBX1, AND ENHANCES DNA BINDING BY PBX1

Paul S Knoepfler;M. P. Kamps

210
Citations
N-myc Is an Essential Downstream Effector of Shh Signaling during both Normal and Neoplastic Cerebellar Growth

Beryl A. Hatton;Paul S. Knoepfler;Anna Marie Kenney;David H. Rowitch

199
Citations
Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

Q. Lu;Paul S Knoepfler;J. Scheele;D. D. Wright

188
Citations
Myc goes global: new tricks for an old oncogene.

Paul S. Knoepfler

184
Citations
myc maintains embryonic stem cell pluripotency and self-renewal.

Natalia V. Varlakhanova;Rebecca F. Cotterman;Rebecca F. Cotterman;Wilhelmine N. deVries;Judy Morgan

183
Citations
N-Myc Regulates a Widespread Euchromatic Program in the Human Genome Partially Independent of Its Role as a Classical Transcription Factor

Rebecca Cotterman;Rebecca Cotterman;Victor X. Jin;Victor X. Jin;Sheryl R. Krig;Jessica M. Lemen

180
Citations
Division and apoptosis of E2f-deficient retinal progenitors

Danian Chen;Marek Pacal;Pamela Wenzel;Paul S. Knoepfler

175
Citations
The Smad transcriptional corepressor TGIF recruits mSin3.

David Wotton;Paul S. Knoepfler;Carol D. Laherty;Robert N. Eisenman

164
Citations
Histone H3.3 mutations: a variant path to cancer.

Benjamin T.K. Yuen;Paul S. Knoepfler

152
Citations
Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail

Paul S. Knoepfler;Paul S. Knoepfler

151
Citations
Histone H3.3 regulates dynamic chromatin states during spermatogenesis.

Benjamin T. K. Yuen;Kelly M. Bush;Bonnie L. Barrilleaux;Rebecca Cotterman

143
Citations

Frequent Co-Authors

Robert N. Eisenman Fred Hutchinson Cancer Research Center

Mark P. Kamps University of California, San Diego

Verónica Martínez-Cerdeño University of California, Davis

Stephen J. Tapscott Fred Hutchinson Cancer Research Center

Lionel Larue University of Paris-Saclay

Andreas Trumpp German Cancer Research Center

Yukiko Gotoh University of Tokyo

Victor X. Jin Medical College of Wisconsin

Martine F. Roussel St. Jude Children's Research Hospital

David E Pleasure University of California, Davis

External Links

Wikipedia of Paul S. Knoepfler Personal website of Paul S. Knoepfler

If you think any of the details on this page are incorrect, let us know.

Related Online Degrees & Career Pathways

Pursuing a degree in Molecular Biology in the USA opens up pathways in research, healthcare, biotechnology, and education. However, students interested in related fields or alternative career routes can explore a growing number of online degree options. Those with a strong interest in quantitative analysis might consider an online math bachelor's degree, which builds analytical and critical thinking skills useful for bioinformatics or data-driven biological research.

Creative-minded students may pursue online graphic design courses to develop strong science communication and visualization skills—important for roles in educational outreach or scientific publishing.

Flexibility and cost are often major considerations. An online interdisciplinary studies tuition costs overview can help students design a curriculum that combines biology, chemistry, and related subjects.

For advanced learners seeking fast and affordable credentials, the quickest cheapest masters degree options online can provide pathways for early career advancement or a transition into teaching, policy, or additional specialized fields.