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Molecular Biology

D-Index
101
Citations
48843
World Ranking
505
National Ranking
280

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2003 - Fellow of the American Academy of Arts and Sciences
  • 1998 - Member of the National Academy of Sciences

Overview

Robert N. Eisenman is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research spans multiple fields including biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, oncology, cancer research, genetics, and hematology.

The scientist's work concentrates on several research topics consistently addressed across publications:

  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • RNA Modifications and Cancer
  • Genomics and Chromatin Dynamics
  • Acute Myeloid Leukemia Research
  • Protein Degradation and Inhibitors

Robert N. Eisenman has published frequently in venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Genes & Development
  • Cancer Cell
  • eLife

Recent papers authored or coauthored by Eisenman demonstrate a focus on cancer biology, transcription regulation, and metabolism. Some notable works include:

  • MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer, 2020, Cancer Cell
  • Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness, 2021, eLife
  • The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells, 2020, Proceedings of the National Academy of Sciences
  • The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis, 2021, PLoS Biology
  • Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia, 2022, Cellular and Molecular Gastroenterology and Hepatology

Frequent collaborators of Eisenman include Patrick A. Carroll, Brian Freie, David MacPherson, Stephanie Dobersch, and Sita Kugel.

Recognitions awarded to Eisenman throughout their career include:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2010
  • Fellow of the American Academy of Arts and Sciences, 2003
  • Member of the National Academy of Sciences, 1998

Best Publications

  • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

    Xinsheng Nan;Huck-Hui Ng;Colin A. Johnson;Carol D. Laherty

  • Max: a helix-loop-helix zipper protein that forms a sequence-specific dna-binding complex with myc and mad

    Elizabeth Marie Blackwood;Robert Neil Eisenman;Donald E. Ayer

  • The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

    Carla Grandori;Shaun M. Cowley;Leonard P. James;Robert N. Eisenman

  • A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.

    Thorsten Heinzel;Robert M. Lavinsky;Tina-Marie Mullen;Mats Söderström

  • Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

    Carol D Laherty;Wen-Ming Yang;Jian-Min Sun;James R Davie

  • Sequence-specific DNA binding by the c-Myc protein

    TK Blackwell;L Kretzner;EM Blackwood;RN Eisenman

  • Myc's broad reach.

    Martin Eilers;Robert N. Eisenman

  • Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

    Hilary A. Coller;Carla Grandori;Pablo Tamayo;Trent Colbert

  • The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

    Markus Welcker;Amir Orian;Jianping Jin;Jonathan A. Grim;Jonathan A. Grim

  • Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

    Donald E. Ayer;Leo Kretzner;Robert N. Eisenman

  • Histone sumoylation is associated with transcriptional repression

    Yuzuru Shiio;Robert N. Eisenman

  • Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.

    Donald E Ayer;Quentin A Lawrence;Robert N Eisenman

  • c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I.

    Carla Grandori;Natividad Gomez-Roman;Zoe A. Felton-Edkins;Celine Ngouenet

  • Drosophila myc Regulates Cellular Growth during Development

    Laura A. Johnston;David A. Prober;Bruce A. Edgar;Robert N. Eisenman

  • Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells.

    S R Hann;R N Eisenman

  • New light on Myc and Myb. Part II. Myb.

    B Lüscher;R N Eisenman

  • N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.

    Paul S. Knoepfler;Pei Feng Cheng;Robert N. Eisenman

  • Myc and Max proteins possess distinct transcriptional activities

    Leo Kretzner;Elizabeth M. Blackwood;Robert N. Eisenman

  • A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas

    Stephen R. Hann;Michael W. King;David L. Bentley;Carl W. Anderson

  • Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation

    Mark Groudine;Robert Eisenman;Harold Weintraub

Frequent Co-Authors

Donald E. Ayer
Donald E. Ayer University of Utah
Bernhard Lüscher
Bernhard Lüscher RWTH Aachen University
Paul S. Knoepfler
Paul S. Knoepfler University of California, Davis
Daniel Raftery
Daniel Raftery University of Washington
Bruce A. Edgar
Bruce A. Edgar Huntsman Cancer Institute
Grant A. McArthur
Grant A. McArthur Peter MacCallum Cancer Centre
Jeffrey J. Delrow
Jeffrey J. Delrow Fred Hutchinson Cancer Research Center
Jay Shendure
Jay Shendure University of Washington
Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center

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