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Molecular Biology

D-Index
94
Citations
41505
World Ranking
645
National Ranking
354

Overview

Edward Seto is affiliated with George Washington University in the United States and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their research emphasizes molecular biology with significant work in oncology, immunology, cancer research, and microbiology.

The scientist has published numerous papers that focus heavily on histone deacetylase inhibitors, protein degradation and inhibitors, peptidase inhibition and analysis, epigenetics and DNA methylation, immune cells in cancer, ubiquitin and proteasome pathways, as well as antimicrobial peptides and activities.

Recent notable publications include:

  • Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection, 2020, Nature Microbiology
  • Regulation of histone deacetylase activities and functions by phosphorylation and its physiological relevance, 2020, Cellular and Molecular Life Sciences
  • HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma, 2020, Cancer Research
  • Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling, 2022, Proceedings of the National Academy of Sciences
  • HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis, 2023, Nature Communications

Frequent coauthors in Edward Seto's research include Changmin Peng, Yixuan Li, Michael F. Emmons, Richard L. Bennett, and Alberto Riva.

Their work has appeared repeatedly in several publication venues, with multiple contributions to Cancer Research, The Journal of Immunology, Journal of Biological Chemistry, and bioRxiv (Cold Spring Harbor Laboratory), alongside appearances in Nature Microbiology.

Best Publications

  • Acetylation and deacetylation of non-histone proteins

    Michele A. Glozak;Nilanjan Sengupta;Xiaohong Zhang;Edward Seto

  • Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

    Edward Seto;Minoru Yoshida

  • A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.

    Thorsten Heinzel;Robert M. Lavinsky;Tina-Marie Mullen;Mats Söderström

  • Histone deacetylases and cancer.

    M A Glozak;E Seto

  • Lysine acetylation: codified crosstalk with other posttranslational modifications

    Xiang Jiao Yang;Xiang Jiao Yang;Edward Seto

  • The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.

    Xiang-Jiao Yang;Edward Seto

  • Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein.

    Yang Shi;Edward Seto;Long Sheng Chang;Thomas Shenk

  • HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention

    Yang Xj;Seto E

  • Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

    Carol D Laherty;Wen-Ming Yang;Jian-Min Sun;James R Davie

  • Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90 A NOVEL BASIS FOR ANTILEUKEMIA ACTIVITY OF HISTONE DEACETYLASE INHIBITORS

    Purva Bali;Michael Pranpat;James Bradner;Maria Balasis

  • HDACs and HDAC Inhibitors in Cancer Development and Therapy

    Yixuan Li;Edward Seto

  • Histone deacetylases, transcriptional control, and cancer.

    W. Douglas Cress;Edward Seto

  • HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

    Xiaohong Zhang;Zhigang Yuan;Yingtao Zhang;Sarah Yong

  • Wild-type p53 binds to the TATA-binding protein and represses transcription.

    Edward Seto;Anny Usheva;Gerard P. Zambetti;Jamil Momand

  • Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

    Wen-Ming Yang;Carla Inouye;Yingying Zeng;David Bearss

  • Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?

    Matthew J. Thomas;Edward Seto

  • Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development

    Kristen Jepsen;Ola Hermanson;Thandi M Onami;Anatoli S Gleiberman

  • Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family

    Wen-Ming Yang;Ya-Li Yao;Jian-Min Sun;James R. Davie

  • Histone Deacetylases Specifically Down-regulate p53-dependent Gene Activation

    Li Jung Juan;Wei Jong Shia;Mei Hui Chen;Wen Ming Yang

  • YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro.

    Edward Seto;Yang Shi;Yang Shi;Thomas Shenk

Frequent Co-Authors

John M. Koomen
John M. Koomen University of South Florida
Jeffrey S. Weber
Jeffrey S. Weber New York University
Kapil N. Bhalla
Kapil N. Bhalla The University of Texas MD Anderson Cancer Center
William S. Lane
William S. Lane Harvard University
Wayne W. Hancock
Wayne W. Hancock University of Pennsylvania
Xiang-Jiao Yang
Xiang-Jiao Yang McGill University
Thomas Shenk
Thomas Shenk Princeton University
Michael G. Rosenfeld
Michael G. Rosenfeld University of California, San Diego
Tso-Pang Yao
Tso-Pang Yao Duke University
James R. Davie
James R. Davie University of Manitoba

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