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Biology and Biochemistry
USA
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
158
Citations
95132
World Ranking
130
National Ranking
96

Medicine

D-Index
158
Citations
95340
World Ranking
851
National Ranking
484

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2017 - Member of the National Academy of Sciences
  • 2008 - Fellow of the American Academy of Arts and Sciences

Overview

Mitchell A. Lazar is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Key subfields include Physiology, Endocrine and Autonomic Systems, Molecular Biology, Epidemiology, and Aging.

The scientist's main research topics encompass circadian rhythm and melatonin, adipose tissue and metabolism, genetics, aging, and longevity in model organisms, dietary effects on health, adipokines, inflammation, and metabolic diseases, liver disease diagnosis and treatment, and pancreatic function and diabetes.

Among recent papers authored or co-authored by Mitchell A. Lazar are:

  • The hepatocyte clock and feeding control chronophysiology of multiple liver cell types (2020, Science)
  • Dichotomous engagement of HDAC3 activity governs inflammatory responses (2020, Nature)
  • Interconnections between circadian clocks and metabolism (2021, Journal of Clinical Investigation)
  • Modelling metabolic diseases and drug response using stem cells and organoids (2022, Nature Reviews Endocrinology)
  • Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice (2023, Nature Communications)

Frequent co-authors include Dongyin Guan, Yang Xiao, Chunjie Jiang, Kun Zhu, and Wenxiang Hu. These collaborations reflect long-term research partnerships and joint contributions to the scientific literature.

Mitchell A. Lazar's work has been published notably in venues such as the Journal of Clinical Investigation, Genes & Development, Nature Communications, Nature Metabolism, and Diabetes. The number of publications indicates a pattern of recurring contributions in these journals.

The scientist has been recognized with membership in the National Academy of Sciences since 2017 and has been a Fellow of the American Academy of Arts and Sciences since 2008.

Best Publications

  • The hormone resistin links obesity to diabetes

    Claire M. Steppan;Shannon T. Bailey;Savitha Bhat;Elizabeth J. Brown

  • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

    Christopher J. Phiel;Fang Zhang;Eric Y. Huang;Matthew G. Guenther

  • Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription.

    Yongfeng Shang;Xiao Hu;James DiRenzo;Mitchell A Lazar

  • The Many Faces of PPARγ

    Michael Lehrke;Mitchell A. Lazar

  • Forming functional fat: a growing understanding of adipocyte differentiation

    Ana G. Cristancho;Mitchell A. Lazar

  • Thyroid hormone receptors : multiple forms, multiple possibilities

    Mitchell A. Lazar

  • Resistin Is an Inflammatory Marker of Atherosclerosis in Humans

    Muredach P. Reilly;Michael Lehrke;Megan L. Wolfe;Anand K Rohatgi

  • Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.

    F Grignani;S De Matteis;Clara Nervi;L Tomassoni

  • International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors

    Liliane Michalik;Johan Auwerx;Joel P. Berger;V. Krishna Chatterjee

  • A unified nomenclature system for the nuclear receptor superfamily

    J. Auwerx;E. Baulieu;M. Beato;M. Becker-Andre

  • Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.

    A Chawla;E J Schwarz;D D Dimaculangan;M A Lazar

  • Mechanisms of obesity-associated insulin resistance: many choices on the menu

    Mohammed Qatanani;Mitchell A. Lazar

  • A family of tissue-specific resistin-like molecules

    Claire M. Steppan;Elizabeth J. Brown;Christopher M. Wright;Savitha Bhat

  • New developments in adipogenesis.

    Martina I. Lefterova;Mitchell A. Lazar

  • A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response.

    Chinyu G. Su;Xiaoming Wen;Shannon T. Bailey;Wen Jiang

  • Regulation of Fasted Blood Glucose by Resistin

    Ronadip R. Banerjee;Shamina M. Rangwala;Jennifer S. Shapiro;A. Sophie Rich

  • Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

    Wolfgang Fischle;Franck Dequiedt;Michael J Hendzel;Matthew G Guenther

  • Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways

    Lei Yin;Nan Wu;Joshua C. Curtin;Mohammed Qatanani

  • The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

    Xiao Hu;Mitchell A. Lazar

  • Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

    Ker Yu;William Bayona;Caleb B. Kallen;Heather P. Harding

Frequent Co-Authors

David J. Steger
David J. Steger University of Pennsylvania
William W. Chin
William W. Chin Harvard Medical School
Rexford S. Ahima
Rexford S. Ahima Johns Hopkins University
Jinsong Zhang
Jinsong Zhang Chinese Academy of Sciences
Gary D. Wu
Gary D. Wu University of Pennsylvania
Joshua D. Rabinowitz
Joshua D. Rabinowitz Princeton University
Yun Li
Yun Li University of North Carolina at Chapel Hill
Jack D. Barchas
Jack D. Barchas Cornell University
Heather P. Harding
Heather P. Harding University of Cambridge
Patrick Seale
Patrick Seale University of Pennsylvania

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