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Biology and Biochemistry

D-Index
69
Citations
27769
World Ranking
7244
National Ranking
3325

Overview

Paul M. Yen is affiliated with Duke University in the United States and has a research focus spanning medicine, biochemistry, genetics, and molecular biology. Their scholarly work addresses intersecting fields such as epidemiology, endocrinology, diabetes and metabolism, molecular biology, physiology, and cell biology.

Their research mainly concentrates on topics including liver disease diagnosis and treatment, diet, metabolism, and disease, folate and B vitamins research, autophagy in disease and therapy, endoplasmic reticulum stress and disease, thyroid disorders and treatments, and adipose tissue and metabolism.

Paul M. Yen has published in frequent venues such as the Journal of Hepatology, bioRxiv (Cold Spring Harbor Laboratory), Autophagy, International Journal of Molecular Sciences, and Thyroid, contributing multiple articles to these journals.

Recent papers by Paul M. Yen include:

  • Thermogenesis in Adipose Tissue Activated by Thyroid Hormone, 2020, International Journal of Molecular Sciences
  • Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH, 2021, Nature Communications
  • Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation, 2022, Journal of Hepatology
  • Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases, 2020, International Journal of Molecular Sciences
  • Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression, 2022, Nature Communications

Frequent coauthors include:

  • Brijesh Kumar Singh
  • Madhulika Tripathi
  • Jin Zhou
  • Rohit A. Sinha
  • Reddemma Sandireddy

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Physiological and molecular basis of thyroid hormone action.

    Paul M. Yen

  • Direct effects of thyroid hormones on hepatic lipid metabolism.

    Rohit A. Sinha;Rohit A. Sinha;Brijesh K. Singh;Paul M. Yen

  • Thyroid Hormone Regulation of Hepatic Genes in Vivo Detected by Complementary DNA Microarray

    Xu Feng;Yuan Jiang;Paul Meltzer;Paul M. Yen

  • Caffeine stimulates hepatic lipid metabolism by the autophagy‐lysosomal pathway in mice

    Rohit A. Sinha;Benjamin L. Farah;Brijesh K. Singh;Monowarul M. Siddique

  • Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism

    Ty C. Voss;R. Louis Schiltz;Myong Hee Sung;Paul M. Yen

  • New insights into thyroid hormone action

    Alexis Oetting;Paul M. Yen

  • Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis

    Anissa A. Widjaja;Brijesh K. Singh;Eleonora Adami;Sivakumar Viswanathan

  • Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

    Rohit Anthony Sinha;Seo Hee You;Jin Zhou;Mobin M. Siddique

  • Thyroid hormone action at the cellular, genomic and target gene levels.

    Paul M. Yen;Paul M. Yen;Shinichiro Ando;Xu Feng;Ying Liu

  • Expression and hormonal regulation of coactivator and corepressor genes.

    Silvia Misiti;Lutz Schomburg;Paul M. Yen;William W. Chin

  • The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin.

    A Shalev;C A Siegrist-Kaiser;P M Yen;W Wahli

  • Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism

    Rohit A. Sinha;Brijesh K. Singh;Paul M. Yen;Paul M. Yen

  • Dynamic Shuttling and Intranuclear Mobility of Nuclear Hormone Receptors

    Padma Maruvada;Christopher T. Baumann;Gordon L. Hager;Paul M. Yen

  • Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator.

    A Takeshita;P M Yen;S Misiti;G R Cardona

  • Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists.

    Rohit A Sinha;Eveline Bruinstroop;Brijesh K Singh;Paul M Yen;Paul M Yen

  • Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers.

    P M Yen;D S Darling;R L Carter;M Forgione

  • Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes.

    Bertrand Saunier;Miriam Triyatni;Luca Ulianich;Padma Maruvada

  • Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates Hepatic Autophagy and Lipid Clearance

    Jin-Xing Zhou;Benjamin Livingston Farah;Rohit Anthony Sinha;Yajun Wu

  • New advances in understanding the molecular mechanisms of thyroid hormone action.

    Paul M. Yen;William W. Chin

Frequent Co-Authors

William W. Chin
William W. Chin Harvard Medical School
Samuel Refetoff
Samuel Refetoff University of Chicago
Boon-Huat Bay
Boon-Huat Bay National University of Singapore
Stuart A. Cook
Stuart A. Cook Duke NUS Graduate Medical School
Jacques Samarut
Jacques Samarut École Normale Supérieure de Lyon
Paul S. Meltzer
Paul S. Meltzer National Institutes of Health
S. Stoney Simons
S. Stoney Simons National Institutes of Health
Gordon L. Hager
Gordon L. Hager National Institutes of Health
Juan Bernal
Juan Bernal Autonomous University of Madrid
J. Larry Jameson
J. Larry Jameson University of Pennsylvania

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