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Medicine

D-Index
112
Citations
39306
World Ranking
5196
National Ranking
2808

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Samuel Refetoff is affiliated with the University of Chicago in the United States. Their research primarily focuses on fields related to Medicine, with significant contributions to Biochemistry, Genetics, and Molecular Biology. Within these main fields, their subfields of study include Endocrinology, Diabetes and Metabolism, Molecular Biology, Genetics, Endocrine and Autonomic Systems, and Cell Biology.

The scientist's work encompasses a range of topics centered around thyroid-related conditions and their underlying mechanisms. Major research topics include:

  • Thyroid Disorders and Treatments
  • Growth Hormone and Insulin-like Growth Factors
  • Genetics and Neurodevelopmental Disorders
  • Thyroid Cancer Diagnosis and Treatment
  • Neuroscience of respiration and sleep
  • Ion channel regulation and function
  • Erythrocyte Function and Pathophysiology

Samuel Refetoff has collaborated extensively with several frequent co-authors, including Xiao-Hui Liao, Alexandra M. Dumitrescu, Roy E. Weiss, Peter Arvan, and Sabine Costagliola. These collaborations have contributed to a steady output of research publications in several academic venues.

Their publications have appeared most frequently in the following journals and proceedings:

  • Thyroid
  • Journal of the Endocrine Society
  • Endocrine Abstracts
  • JCI Insight
  • bioRxiv (Cold Spring Harbor Laboratory)

Some recent notable papers authored or co-authored by Samuel Refetoff include:

  • "SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies," Cancer Discovery, 2020
  • "Resistance to Thyroid Hormone Beta: A Focused Review," Frontiers in Endocrinology, 2021
  • "Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut," Immunity, 2023
  • "Increased Hepatic Fat Content in Patients with Resistance to Thyroid Hormone Beta," Thyroid, 2020
  • "Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism," Nature Communications, 2022

Throughout their career, Refetoff has published extensively on thyroid hormone mechanisms and related metabolic phenomena. Their research spans molecular biology pathways, clinical endocrinology, and aspects of cellular stress responses. This broad range connects to both fundamental biology and potential clinical applications, especially regarding thyroid hormone resistance and thyroid cancer.

Samuel Refetoff is recognized as a member of the Association of American Physicians, an affiliation reflecting professional engagement within the medical research community.

Best Publications

  • The Syndromes of Resistance to Thyroid Hormone

    Samuel Refetoff;Roy E. Weiss;Stephen J. Usala

  • A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene.

    Alexandra M. Dumitrescu;Xiao-Hui Liao;Thomas B. Best;Knut Brockmann

  • Familial Syndrome Combining Deaf-Mutism, Stippled Epiphyses, Goiter and Abnormally High PBI: Possible Target Organ Refractoriness to Thyroid Hormone12

    Samuel Refetoff;Loren T. Dewind;Leslie J. Degroot

  • Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep.

    E Van Cauter;J D Blackman;D Roland;J P Spire

  • Mutations in SECISBP2 result in abnormal thyroid hormone metabolism.

    Alexandra M. Dumitrescu;Xiao Hui Liao;Mohamed S.Y. Abdullah;Joaquin Lado-Abeal;Joaquin Lado-Abeal

  • Targeted Expression of BRAFV600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation

    Jeffrey A. Knauf;Xiaolan Ma;Eric P. Smith;Lei Zhang

  • Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene.

    Thongkum Sunthornthepvarakul;Michael E. Gottschalk;Yoshitaka Hayashi;Samuel Refetoff

  • Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

    Debyani Chakravarty;Elmer Santos;Mabel M Ryder;Jeffrey A. Knauf

  • Generation of functional thyroid from embryonic stem cells.

    Francesco Antonica;Dominika Figini Kasprzyk;Robert Opitz;Michelina Iacovino

  • Reduced clearance rate of thyroxine-binding globulin (TBG) with increased sialylation: a mechanism for estrogen-induced elevation of serum TBG concentration.

    Kenneth B. Ain;Yuichi Mori;Samuel Refetoff

  • Resistance to thyroid hormone.

    Roy E. Weiss;Samuel Refetoff

  • Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent

    Helmut Grasberger;Samuel Refetoff

  • Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice.

    Alexandra M. Dumitrescu;Xiao Hui Liao;Roy E. Weiss;Kathleen Millen

  • Fetal Loss Associated With Excess Thyroid Hormone Exposure

    João Anselmo;Dingcai Cao;Theodore Karrison;Roy E. Weiss

  • Syndromes of reduced sensitivity to thyroid hormone : genetic defects in hormone receptors, cell transporters and deiodination

    Samuel Refetoff;Alexandra M. Dumitrescu

  • Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta

    Akihiro Sakurai;Kyoko Takeda;Kenneth Ain;Paola Ceccarelli

  • Thyroid Hormone Induces Rapid Activation of Akt/Protein Kinase B-Mammalian Target of Rapamycin-p70S6K Cascade through Phosphatidylinositol 3-Kinase in Human Fibroblasts

    Xia Cao;Fukushi Kambe;Lars C. Moeller;Samuel Refetoff

  • Thyroid Dysfunction in Chronic Renal Failure: A STUDY OF THE PITUITARY-THYROID AXIS AND PERIPHERAL TURNOVER KINETICS OF THYROXINE AND TRIIODOTHYRONINE

    Victoria Sy Lim;Victor S. Fang;Adrian I. Katz;Samuel Refetoff

  • Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood.

    Refetoff S;Harrison J;Karanfilski Bt;Kaplan El

  • Nocturnal exercise phase delays circadian rhythms of melatonin and thyrotropin secretion in normal men.

    O. Van Reeth;J. Sturis;M. M. Byrne;J. D. Blackman

Frequent Co-Authors

Gilbert Vassart
Gilbert Vassart Université Libre de Bruxelles
Paul M. Yen
Paul M. Yen Duke University
Leslie J. DeGroot
Leslie J. DeGroot University of Chicago
Eve Van Cauter
Eve Van Cauter University of Chicago
Juan Bernal
Juan Bernal Autonomous University of Madrid
Jacques Samarut
Jacques Samarut École Normale Supérieure de Lyon
Sabine Costagliola
Sabine Costagliola Université Libre de Bruxelles
Luca Persani
Luca Persani University of Milan
Paolo Beck-Peccoz
Paolo Beck-Peccoz University of Milan
William W. Chin
William W. Chin Harvard Medical School

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