World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
12324
World Ranking
10357
National Ranking
189

Overview

Sabine Costagliola is affiliated with the Université Libre de Bruxelles in Belgium, focusing on research within the broad field of Biochemistry, Genetics and Molecular Biology. Their work spans molecular biology, genetics, endocrinology, diabetes and metabolism, biomedical engineering, and oncology, reflecting a multidisciplinary approach to life sciences.

The main topics covered in their research include renal and related cancers, single-cell and spatial transcriptomics, congenital heart defects research, thyroid disorders and treatments, genetic and clinical aspects of sex determination and chromosomal abnormalities, cancer cells and metastasis, and interferon and immune responses.

Costagliola has contributed to numerous publications, frequently appearing in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Advanced Healthcare Materials
  • Yearbook of Pediatric Endocrinology
  • Endocrine Abstracts
  • The American Journal of Human Genetics

Their recent papers include:

  • Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism, 2022, Nature Communications
  • Single-cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland, 2020, EMBO Reports
  • A form of muscular dystrophy associated with pathogenic variants in JAG2, 2021, The American Journal of Human Genetics
  • Thyroid-on-a-Chip: An Organoid Platform for In Vitro Assessment of Endocrine Disruption, 2022, Advanced Healthcare Materials
  • Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids, 2023, Oncogene

Frequent co-authors collaborating with Costagliola are:

  • Mírian Romitti
  • Pierre Gillotay
  • Vincent Detours
  • Sumeet Pal Singh
  • Lorenzo Moroni

The research output highlights a significant engagement with cutting-edge techniques such as organoid platforms and single-cell transcriptomics, which are applied to study thyroid function, cancer biology, and genetic disorders. This is indicated by their contributions to understanding thyroid gland cell diversity and exploring new therapeutic interventions for thyroid and muscular disorders.

Costagliola's work reflects an intersection of molecular biology and biomedical engineering fields, particularly in the development of innovative in vitro models to assess endocrine disruption and cancer redifferentiation strategies. The extensive publication record in notable journals and preprint platforms underlines an ongoing contribution to multiple subfields of biomedical research.

Best Publications

  • Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.

    Xavier De Deken;Dantong Wang;Marie-Christine Many;Sabine Costagliola

  • A molecular dissection of the glycoprotein hormone receptors.

    Gilbert Vassart;Leonardo Pardo;Sabine Costagliola

  • Second Generation Assay for Thyrotropin Receptor Antibodies Has Superior Diagnostic Sensitivity for Graves’ Disease

    Sabine Costagliola;Nils G. Morgenthaler;Rudolf Hoermann;Klaus Badenhoop

  • Familial Gestational Hyperthyroidism Caused by a Mutant Thyrotropin Receptor Hypersensitive to Human Chorionic Gonadotropin

    P. Rodien;C. Bremont;M.-L. R. Sanson;J. Parma

  • Generation of functional thyroid from embryonic stem cells.

    Francesco Antonica;Dominika Figini Kasprzyk;Robert Opitz;Michelina Iacovino

  • Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.

    J Parma;L Duprez;J Van Sande;J Hermans

  • Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.

    Guillaume Smits;Olufemi Olatunbosun;Anne Delbaere;Roger Pierson

  • Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.

    Eneko Urizar;Lucia Montanelli;Tiffany Loy;Marco Bonomi

  • Activation of the cAMP Pathway by the TSH Receptor Involves Switching of the Ectodomain from a Tethered Inverse Agonist to an Agonist

    Virginie Vlaeminck-Guillem;Su-Chin Ho;Patrice Rodien;Gilbert Vassart

  • Genetic Immunization Against the Human Thyrotropin Receptor Causes Thyroiditis and Allows Production of Monoclonal Antibodies Recognizing the Native Receptor

    Sabine Costagliola;P Rodien;Marie-Christine Many;Marian Ludgate

  • Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

    Sabine Costagliola;Valérie Panneels;M Bonomi;J Koch

  • Anion Selectivity by the Sodium Iodide Symporter

    J. Van Sande;C. Massart;R. Beauwens;A. Schoutens

  • Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity

    Guillaume Smits;Mercedes Campillo;Cédric Govaerts;Cédric Govaerts;Véronique Janssens

  • Autosomal dominant transmission of congenital thyroid hypoplasia due to loss-of-function mutation of PAX8.

    Catheline Vilain;Catherine Rydlewski;Laurence Duprez;Claudine Heinrichs

  • Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves’ disease

    Sabine Costagliola;Marie-Christine Many;Jean François Denef;Joachim Pohlenz

  • G protein-coupled receptors: mutations and endocrine diseases

    Gilbert Vassart;Sabine Costagliola

  • Prediction of severity of symptoms in iatrogenic ovarian hyperstimulation syndrome by follicle-stimulating hormone receptor Ser680Asn polymorphism.

    Caroline Daelemans;Guillaume Smits;Viviane de Maertelaer;Sabine Costagliola

  • Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology.

    A. De Leener;L. Montanelli;J. Van Durme;Heedong Chae

  • A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome.

    Lucia Montanelli;Anne Delbaere;Costantino Di Carlo;Carmine Nappi

  • Constitutive activation of the TSH receptor by spontaneous mutations affecting the N-terminal extracellular domain.

    Laurence Duprez;Jasmine Parma;Sabine Costagliola;Jacques Hermans

Frequent Co-Authors

Gilbert Vassart
Gilbert Vassart Université Libre de Bruxelles
Jacques Emile Dumont
Jacques Emile Dumont Université Libre de Bruxelles
Leonardo Pardo
Leonardo Pardo Autonomous University of Barcelona
Nils G. Morgenthaler
Nils G. Morgenthaler Charité - University Medicine Berlin
Samuel Refetoff
Samuel Refetoff University of Chicago
Frédérick Libert
Frédérick Libert Université Libre de Bruxelles
Marc Parmentier
Marc Parmentier Université Libre de Bruxelles
Mario Manto
Mario Manto University of Mons
Sylvie Claeysen
Sylvie Claeysen Inserm : Institut national de la santé et de la recherche médicale

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Sabine Costagliola

Trending Scientists

Recently Published Articles