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Sylvie Claeysen

Sylvie Claeysen

Inserm : Institut national de la santé et de la recherche médicale
France

Overview

What is she best known for?

The fields of study she is best known for:

Gene
G protein-coupled receptor
Genetics

Her primary areas of study are Receptor, G protein-coupled receptor, Pharmacology, Partial agonist and Neuroscience. Her biological study spans a wide range of topics, including Molecular biology and Signal transduction. Her research integrates issues of Open reading frame and Drosophila Protein in her study of G protein-coupled receptor.

In her study, In vivo, Serotonin and G protein is inextricably linked to Agonist, which falls within the broad field of Pharmacology. The study incorporates disciplines such as Inverse agonist, 5-HT1 receptor, δ-opioid receptor and 5-HT7 receptor in addition to Neuroscience. Her work deals with themes such as Cystine knot and Rhodopsin-like receptors, which intersect with Cell biology.

Her most cited work include:

Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation (196 citations)
Engineering GPCR signaling pathways with RASSLs (188 citations)
5-HT4 receptors. (180 citations)

What are the main themes of her work throughout her whole career to date?

Sylvie Claeysen focuses on Receptor, G protein-coupled receptor, Neuroscience, Cell biology and Biochemistry. Her work carried out in the field of Receptor brings together such families of science as Molecular biology and Pharmacology. Her G protein-coupled receptor research incorporates elements of 5-HT7 receptor, 5-HT receptor, Rhodopsin-like receptors, Metabotropic receptor and G protein.

Her study in Neuroscience is interdisciplinary in nature, drawing from both Inflammation, Dementia, Disease and Serotonin. Her research on Cell biology focuses in particular on Arrestin. Her research in the fields of Wild type and Mutant overlaps with other disciplines such as Hormone receptor, Rhodopsin and Thyrotropin receptor.

She most often published in these fields:

Receptor (84.27%)
G protein-coupled receptor (70.79%)
Neuroscience (51.69%)

What were the highlights of her more recent work (between 2014-2021)?

Neuroscience (51.69%)
Disease (32.58%)
Receptor (84.27%)

In recent papers she was focusing on the following fields of study:

Her main research concerns Neuroscience, Disease, Receptor, G protein-coupled receptor and In vivo. Her Neuroscience research is multidisciplinary, incorporating elements of Inflammation, Alzheimer's disease, Dementia and Serotonin. Her work on Amyloid is typically connected to Multi target as part of general Disease study, connecting several disciplines of science.

In the subject of general Receptor, her work in Serotonergic is often linked to Structure and function, thereby combining diverse domains of study. Her G protein-coupled receptor study results in a more complete grasp of Cell biology. Sylvie Claeysen combines subjects such as Internalization and Rhodopsin-like receptors with her study of Cell biology.

Between 2014 and 2021, her most popular works were:

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride. (72 citations)
Serotonin: A New Hope in Alzheimer's Disease? (63 citations)
Serotonin: A New Hope in Alzheimer's Disease? (63 citations)

In her most recent research, the most cited papers focused on:

Gene
G protein-coupled receptor
Genetics

The scientist’s investigation covers issues in Synaptic cleft, Neuroprotection, Dementia, Disease and Symptomatic relief. Her Synaptic cleft research is multidisciplinary, relying on both Neuroscience and Serotonin.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation

Joël Bockaert;Sylvie Claeysen;Carine Bécamel;Aline Dumuis.
Cell and Tissue Research (2006)

304 Citations

Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.

Sylvie Claeysen;Michèle Sebben;Carine Becamel;Joël Bockaert.
Molecular Pharmacology (1999)

263 Citations

Engineering GPCR signaling pathways with RASSLs

Bruce R. Conklin;Edward C. Hsiao;Sylvie Claeysen;Aline Dumuis.
Nature Methods (2008)

254 Citations

5-HT4 receptors.

Joël Bockaert;S. Claeysen;Valerie Compan;Aline Dumuis.
Current Drug Targets - Cns & Neurological Disorders (2004)

239 Citations

Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2.

Fernando M. Mendive;Tom Van Loy;Sylvie Claeysen;Jeroen Poels.
FEBS Letters (2005)

160 Citations

New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4(a) receptor splice variant: roles in receptor targeting

Lara Joubert;Brendon Hanson;Gaël Barthet;Michèle Sebben.
Journal of Cell Science (2004)

158 Citations

An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.

Eneko Urizar;Eneko Urizar;Sylvie Claeysen;Xavier Deupí;Cedric Govaerts.
Journal of Biological Chemistry (2005)

140 Citations

5-HT4 receptors: History, molecular pharmacology and brain functions

Joël Bockaert;Sylvie Claeysen;Sylvie Claeysen;Sylvie Claeysen;Valérie Compan;Valérie Compan;Valérie Compan;Aline Dumuis;Aline Dumuis;Aline Dumuis.
Neuropharmacology (2008)

128 Citations

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.

Christophe Rochais;Cédric Lecoutey;Florence Gaven;Florence Gaven;Florence Gaven;Patrizia Giannoni;Patrizia Giannoni;Patrizia Giannoni.
Journal of Medicinal Chemistry (2015)

115 Citations

Serotonin: A New Hope in Alzheimer's Disease?

Sylvie Claeysen;Sylvie Claeysen;Sylvie Claeysen;Joël Bockaert;Joël Bockaert;Joël Bockaert;Patrizia Giannoni;Patrizia Giannoni;Patrizia Giannoni.
ACS Chemical Neuroscience (2015)

111 Citations

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