World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
36
Citations
5019
World Ranking
9026
National Ranking
436

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • G protein-coupled receptor
  • Genetics

Her primary areas of study are Receptor, G protein-coupled receptor, Pharmacology, Partial agonist and Neuroscience. Her biological study spans a wide range of topics, including Molecular biology and Signal transduction. Her research integrates issues of Open reading frame and Drosophila Protein in her study of G protein-coupled receptor.

In her study, In vivo, Serotonin and G protein is inextricably linked to Agonist, which falls within the broad field of Pharmacology. The study incorporates disciplines such as Inverse agonist, 5-HT1 receptor, δ-opioid receptor and 5-HT7 receptor in addition to Neuroscience. Her work deals with themes such as Cystine knot and Rhodopsin-like receptors, which intersect with Cell biology.

Her most cited work include:

  • Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation (196 citations)
  • Engineering GPCR signaling pathways with RASSLs (188 citations)
  • 5-HT4 receptors. (180 citations)

What are the main themes of her work throughout her whole career to date?

Sylvie Claeysen focuses on Receptor, G protein-coupled receptor, Neuroscience, Cell biology and Biochemistry. Her work carried out in the field of Receptor brings together such families of science as Molecular biology and Pharmacology. Her G protein-coupled receptor research incorporates elements of 5-HT7 receptor, 5-HT receptor, Rhodopsin-like receptors, Metabotropic receptor and G protein.

Her study in Neuroscience is interdisciplinary in nature, drawing from both Inflammation, Dementia, Disease and Serotonin. Her research on Cell biology focuses in particular on Arrestin. Her research in the fields of Wild type and Mutant overlaps with other disciplines such as Hormone receptor, Rhodopsin and Thyrotropin receptor.

She most often published in these fields:

  • Receptor (84.27%)
  • G protein-coupled receptor (70.79%)
  • Neuroscience (51.69%)

What were the highlights of her more recent work (between 2014-2021)?

  • Neuroscience (51.69%)
  • Disease (32.58%)
  • Receptor (84.27%)

In recent papers she was focusing on the following fields of study:

Her main research concerns Neuroscience, Disease, Receptor, G protein-coupled receptor and In vivo. Her Neuroscience research is multidisciplinary, incorporating elements of Inflammation, Alzheimer's disease, Dementia and Serotonin. Her work on Amyloid is typically connected to Multi target as part of general Disease study, connecting several disciplines of science.

In the subject of general Receptor, her work in Serotonergic is often linked to Structure and function, thereby combining diverse domains of study. Her G protein-coupled receptor study results in a more complete grasp of Cell biology. Sylvie Claeysen combines subjects such as Internalization and Rhodopsin-like receptors with her study of Cell biology.

Between 2014 and 2021, her most popular works were:

  • Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride. (72 citations)
  • Serotonin: A New Hope in Alzheimer's Disease? (63 citations)
  • Serotonin: A New Hope in Alzheimer's Disease? (63 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • G protein-coupled receptor
  • Genetics

The scientist’s investigation covers issues in Synaptic cleft, Neuroprotection, Dementia, Disease and Symptomatic relief. Her Synaptic cleft research is multidisciplinary, relying on both Neuroscience and Serotonin.

Best Publications

  • Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation

    Joël Bockaert;Sylvie Claeysen;Carine Bécamel;Aline Dumuis

  • Engineering GPCR signaling pathways with RASSLs

    Bruce R. Conklin;Edward C. Hsiao;Sylvie Claeysen;Aline Dumuis

  • Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.

    Sylvie Claeysen;Michèle Sebben;Carine Becamel;Joël Bockaert

  • 5-HT4 receptors.

    Joël Bockaert;S. Claeysen;Valerie Compan;Aline Dumuis

  • International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

    Nicholas M. Barnes;Gerard P. Ahern;Carine Becamel;Joël Bockaert

  • Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2.

    Fernando M. Mendive;Tom Van Loy;Sylvie Claeysen;Jeroen Poels

  • New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4(a) receptor splice variant: roles in receptor targeting

    Lara Joubert;Brendon Hanson;Gaël Barthet;Michèle Sebben

  • Cerebrovascular pathology during the progression of experimental Alzheimer's disease.

    Patrizia Giannoni;Margarita Arango-Lievano;Ines Das Neves;Marie-Claude Rousset

  • 5-HT4 receptors: History, molecular pharmacology and brain functions

    Joël Bockaert;Sylvie Claeysen;Sylvie Claeysen;Sylvie Claeysen;Valérie Compan;Valérie Compan;Valérie Compan;Aline Dumuis;Aline Dumuis;Aline Dumuis

  • Serotonin: A New Hope in Alzheimer's Disease?

    Sylvie Claeysen;Sylvie Claeysen;Sylvie Claeysen;Joël Bockaert;Joël Bockaert;Joël Bockaert;Patrizia Giannoni;Patrizia Giannoni;Patrizia Giannoni

  • Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.

    Christophe Rochais;Cédric Lecoutey;Florence Gaven;Florence Gaven;Florence Gaven;Patrizia Giannoni;Patrizia Giannoni;Patrizia Giannoni

  • An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.

    Eneko Urizar;Eneko Urizar;Sylvie Claeysen;Xavier Deupí;Cedric Govaerts

  • Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

    Cédric Lecoutey;Damien Hedou;Thomas Freret;Patrizia Giannoni

  • 5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

    Maud Cochet;Romain Donneger;Romain Donneger;Elisabeth Cassier;Elisabeth Cassier;Florence Gaven

  • Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer’s disease

    Patrizia Giannoni;Patrizia Giannoni;Florence Gaven;Florence Gaven;Dimitri de Bundel;Dimitri de Bundel;Kevin Baranger;Kevin Baranger

  • Alzheimer culprits: cellular crossroads and interplay.

    Sylvie Claeysen;Maud Cochet;Maud Cochet;Romain Donneger;Romain Donneger;Aline Dumuis;Aline Dumuis

  • G protein-coupled receptors: dominant players in cell-cell communication.

    Joël Bockaert;Sylvie Claeysen;Carine Becamel;Sylvie Pinloche

  • A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL).

    Sylvie Claeysen;Lara Joubert;Michèle Sebben;Joël Bockaert

  • Cloning, expression and pharmacology of the mouse 5-HT4L receptor

    Sylvie Claeysen;Michèle Sebben;Laurent Journot;Joël Bockaert

  • Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.

    Lucie P. Pellissier;Jessica Sallander;Mercedes Campillo;Florence Gaven

  • G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient

    Lucie P. Pellissier;Lucie P. Pellissier;Gaël Barthet;Gaël Barthet;Florence Gaven;Florence Gaven;Elisabeth Cassier;Elisabeth Cassier

Frequent Co-Authors

Joël Bockaert
Joël Bockaert University of Montpellier
Philippe Marin
Philippe Marin University of Montpellier
Nicola Marchi
Nicola Marchi Centre national de la recherche scientifique, CNRS
Emmanuel Valjent
Emmanuel Valjent Centre national de la recherche scientifique, CNRS
Ken D. McCarthy
Ken D. McCarthy University of North Carolina at Chapel Hill
Frank Hauser
Frank Hauser University of Copenhagen
Barbara Borroni
Barbara Borroni University of Brescia
Evelyn K. Lambe
Evelyn K. Lambe University of Toronto
Alessandro Padovani
Alessandro Padovani University of Brescia

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