Inserm : Institut national de la santé et de la recherche médicale
Her primary areas of study are Receptor, G protein-coupled receptor, Pharmacology, Partial agonist and Neuroscience. Her biological study spans a wide range of topics, including Molecular biology and Signal transduction. Her research integrates issues of Open reading frame and Drosophila Protein in her study of G protein-coupled receptor.
In her study, In vivo, Serotonin and G protein is inextricably linked to Agonist, which falls within the broad field of Pharmacology. The study incorporates disciplines such as Inverse agonist, 5-HT1 receptor, δ-opioid receptor and 5-HT7 receptor in addition to Neuroscience. Her work deals with themes such as Cystine knot and Rhodopsin-like receptors, which intersect with Cell biology.
Sylvie Claeysen focuses on Receptor, G protein-coupled receptor, Neuroscience, Cell biology and Biochemistry. Her work carried out in the field of Receptor brings together such families of science as Molecular biology and Pharmacology. Her G protein-coupled receptor research incorporates elements of 5-HT7 receptor, 5-HT receptor, Rhodopsin-like receptors, Metabotropic receptor and G protein.
Her study in Neuroscience is interdisciplinary in nature, drawing from both Inflammation, Dementia, Disease and Serotonin. Her research on Cell biology focuses in particular on Arrestin. Her research in the fields of Wild type and Mutant overlaps with other disciplines such as Hormone receptor, Rhodopsin and Thyrotropin receptor.
Her main research concerns Neuroscience, Disease, Receptor, G protein-coupled receptor and In vivo. Her Neuroscience research is multidisciplinary, incorporating elements of Inflammation, Alzheimer's disease, Dementia and Serotonin. Her work on Amyloid is typically connected to Multi target as part of general Disease study, connecting several disciplines of science.
In the subject of general Receptor, her work in Serotonergic is often linked to Structure and function, thereby combining diverse domains of study. Her G protein-coupled receptor study results in a more complete grasp of Cell biology. Sylvie Claeysen combines subjects such as Internalization and Rhodopsin-like receptors with her study of Cell biology.
The scientist’s investigation covers issues in Synaptic cleft, Neuroprotection, Dementia, Disease and Symptomatic relief. Her Synaptic cleft research is multidisciplinary, relying on both Neuroscience and Serotonin.
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation
Joël Bockaert;Sylvie Claeysen;Carine Bécamel;Aline Dumuis.
Cell and Tissue Research (2006)
Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.
Sylvie Claeysen;Michèle Sebben;Carine Becamel;Joël Bockaert.
Molecular Pharmacology (1999)
Engineering GPCR signaling pathways with RASSLs
Bruce R. Conklin;Edward C. Hsiao;Sylvie Claeysen;Aline Dumuis.
Nature Methods (2008)
Joël Bockaert;S. Claeysen;Valerie Compan;Aline Dumuis.
Current Drug Targets - Cns & Neurological Disorders (2004)
Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2.
Fernando M. Mendive;Tom Van Loy;Sylvie Claeysen;Jeroen Poels.
FEBS Letters (2005)
New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4(a) receptor splice variant: roles in receptor targeting
Lara Joubert;Brendon Hanson;Gaël Barthet;Michèle Sebben.
Journal of Cell Science (2004)
An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.
Eneko Urizar;Eneko Urizar;Sylvie Claeysen;Xavier Deupí;Cedric Govaerts.
Journal of Biological Chemistry (2005)
5-HT4 receptors: History, molecular pharmacology and brain functions
Joël Bockaert;Sylvie Claeysen;Sylvie Claeysen;Sylvie Claeysen;Valérie Compan;Valérie Compan;Valérie Compan;Aline Dumuis;Aline Dumuis;Aline Dumuis.
Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.
Christophe Rochais;Cédric Lecoutey;Florence Gaven;Florence Gaven;Florence Gaven;Patrizia Giannoni;Patrizia Giannoni;Patrizia Giannoni.
Journal of Medicinal Chemistry (2015)
Serotonin: A New Hope in Alzheimer's Disease?
Sylvie Claeysen;Sylvie Claeysen;Sylvie Claeysen;Joël Bockaert;Joël Bockaert;Joël Bockaert;Patrizia Giannoni;Patrizia Giannoni;Patrizia Giannoni.
ACS Chemical Neuroscience (2015)
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