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Neuroscience

D-Index
47
Citations
10095
World Ranking
6372
National Ranking
2775

Research.com Recognitions

  • 1998 - Fellow of Alfred P. Sloan Foundation

Overview

Paul A. Slesinger is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research spans several intersecting fields of biochemistry, genetics, molecular biology, and neuroscience. The body of work reflects a focus on molecular biology, cellular and molecular neuroscience, genetics, neurology, and pathology and forensic medicine.

Their scientific investigations cover a range of topics, including:

  • Neuroscience and neuropharmacology research
  • Receptor mechanisms and signaling
  • Ion channel regulation and function
  • Photoreceptor and optogenetics research
  • Alcohol consumption and health effects
  • Neuroinflammation and neurodegeneration mechanisms
  • Genetic associations and epidemiology

Among their recent papers are:

  • "Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction," 2021, Nature Neuroscience
  • "Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease," 2020, Neuron
  • "Structure of human GABAB receptor in an inactive state," 2020, Nature
  • "Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases," 2021, Nature Communications
  • "Near-Infrared Light Triggered-Release in Deep Brain Regions Using Ultra-photosensitive Nanovesicles," 2020, Angewandte Chemie International Edition

Frequently collaborating researchers include:

  • Howard J. Edenberg (20 publications)
  • Danielle M. Dick (20 publications)
  • Jay A. Tischfield (19 publications)
  • Ronald P. Hart (19 publications)
  • Alison Goate (18 publications)

Their work has been published widely in reputable scientific venues with numerous contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory) - 14 publications
  • Nature Communications - 4 publications
  • Molecular Psychiatry - 4 publications
  • Nature - 3 publications
  • Genes Brain & Behavior - 3 publications

Paul A. Slesinger's research integrates multi-disciplinary methods to explore genetic and molecular bases of neurological conditions and behavior. Their focus on receptor mechanisms, ion channel function, and neuropharmacological pathways reflects a comprehensive approach to understanding brain function and disorders related to addiction and neurodegeneration.

In 1998, they were recognized as a Fellow of the Alfred P. Sloan Foundation, an award given to early-career scientists demonstrating promise in their fields.

Best Publications

  • Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

    Christian Lüscher;Paul A. Slesinger

  • An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

    Julia Tcw;Minghui Wang;Anna A. Pimenova;Kathryn R. Bowles

  • Mutant mice and neuroscience: Recommendations concerning genetic background

    Alcino J. Silva;Elizabeth M. Simpson;Joseph S. Takahashi;Hans Peter Lipp

  • Bi-directional effects of GABA B receptor agonists on the mesolimbic dopamine system

    Hans G Cruz;Tatiana Ivanova;Marie-Louise Lunn;Markus Stoffel

  • Functional Effects of the Mouse weaver Mutation on G Protein–Gated Inwardly Rectifying K+ Channels

    Paul A Slesinger;Nila Patil;Y.Joyce Liao;Yuh Nung Jan

  • Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification.

    Scott Pegan;Christine Arrabit;Wei Zhou;Witek Kwiatkowski

  • GABAB Receptor Coupling to G-proteins and Ion Channels

    Claire L Padgett;Paul A Slesinger

  • Genetically encoding unnatural amino acids for cellular and neuronal studies

    Wenyuan Wang;Jeffrey K Takimoto;Gordon V Louie;Thomas J Baiga

  • RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.

    Gwenaël Labouèbe;Marta Lomazzi;Hans G Cruz;Cyril Creton

  • A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction

    Marie-Louise Lunn;Rounak Nassirpour;Rounak Nassirpour;Christine Arrabit;Joshua Tan

  • Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

    Minghui Wang;Aiqun Li;Michiko Sekiya;Noam D. Beckmann

  • A discrete alcohol pocket involved in GIRK channel activation

    Prafulla Aryal;Hay Dvir;Senyon Choe;Senyon Choe;Paul A Slesinger;Paul A Slesinger

  • Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells.

    Seok-Man Ho;Brigham J. Hartley;Julia Tcw;Michael Beaumont

  • The S4–S5 loop contributes to the ion-selective pore of potassium channels

    Paul A. Slesinger;Yuh Nung Jan;Lily Yeh Jan

  • Cell-based reporters reveal in vivo dynamics of dopamine and norepinephrine release in murine cortex

    Arnaud Muller;Victory Joseph;Paul A Slesinger;David Kleinfeld

  • Methamphetamine-evoked Depression of GABA(B) Receptor Signaling in GABA Neurons of the VTA

    Claire L. Padgett;Arnaud L. Lalive;Kelly R. Tan;Miho Terunuma

  • Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.

    Paul A. Slesinger;Markus Stoffel;Yuh Nung Jan;Lily Y. Jan

  • In Vivo Expression of a Light-Activatable Potassium Channel Using Unnatural Amino Acids

    Ji-Yong Kang;Daichi Kawaguchi;Irene Coin;Zheng Xiang

  • Evidence for association of GABAB receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins

    Unknown

  • Chromatin Landscape Defined by Repressive Histone Methylation during Oligodendrocyte Differentiation

    Jia Liu;Laura Magri;Fan Zhang;Nidaa O. Marsh

  • Pertussis-toxin-sensitive Gα subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex

    Sinead M. Clancy;Catherine E. Fowler;Melissa Finley;Ka Fai Suen

  • Evidence for a Centrally Located Gate in the Pore of a Serotonin-Gated Ion Channel

    Sandip Panicker;Hans Cruz;Christine Arrabit;Paul A. Slesinger;Paul A. Slesinger

  • Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels.

    Wei Zhou;Christine Arrabit;Senyon Choe;Paul A. Slesinger

  • Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27.

    Bartosz Balana;Innokentiy Maslennikov;Witek Kwiatkowski;Kalyn M. Stern

Frequent Co-Authors

Christian Lüscher
Christian Lüscher University of Geneva
Stephen J. Moss
Stephen J. Moss Tufts University
David Kleinfeld
David Kleinfeld University of California, San Diego
Bin Zhang
Bin Zhang Icahn School of Medicine at Mount Sinai
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai
Schahram Akbarian
Schahram Akbarian Icahn School of Medicine at Mount Sinai
Rafael Luján
Rafael Luján University of Castilla-La Mancha
Eric E. Schadt
Eric E. Schadt Icahn School of Medicine at Mount Sinai
Jubao Duan
Jubao Duan University of Chicago
David J. Adams
David J. Adams Wellcome Sanger Institute

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