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Biology and Biochemistry

D-Index
61
Citations
23982
World Ranking
11105
National Ranking
4805

Overview

Fumihiko Urano is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with a total of 96 and 59 publications respectively. Subfields of study include Surgery, Molecular Biology, Cell Biology, Genetics, and Physiology.

The scientist's work covers a range of topics focusing heavily on metabolic and cellular mechanisms, particularly relating to diabetes and associated disorders. Key research topics include Endoplasmic Reticulum Stress and Disease, Pancreatic function and diabetes, Genetics and Neurodevelopmental Disorders, Pancreatitis Pathology and Treatment, Adenosine and Purinergic Signaling, and RNA regulation and disease.

Fumihiko Urano's recent published papers demonstrate the scope and depth of their research contributions. These include:

  • "Gene-edited human stem cell-derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice" (2020, Science Translational Medicine)
  • "Primary cilia control glucose homeostasis via islet paracrine interactions" (2020, Proceedings of the National Academy of Sciences)
  • "Neuroplastin Modulates Anti-inflammatory Effects of MANF" (2020, iScience)
  • "Palmitoylation couples insulin hypersecretion with β cell failure in diabetes" (2023, Cell Metabolism)
  • "Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome" (2020, Proceedings of the National Academy of Sciences)

The scientist collaborates frequently with other researchers, including Cris Brown (12 coauthored works), Stephen Stone (10), Shuntaro Morikawa (8), Damien Abreu (7), and Maria Lindahl (7).

Fumihiko Urano's research has appeared notably in venues such as bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Journal of the Endocrine Society, Journal of the American Society of Nephrology, and Nature Communications. They have multiple publications in each of these journals, highlighting a consistent presence in both preprint and peer-reviewed scientific outlets.

Best Publications

  • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

    Fumihiko Urano;Xiao Zhong Wang;Anne Bertolotti;Yuhong Zhang

  • IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

    Marcella Calfon;Huiqing Zeng;Fumihiko Urano;Jeffery H Till

  • Autophagy Is Activated for Cell Survival after Endoplasmic Reticulum Stress

    Maiko Ogata;Shin Ichiro Hino;Atsushi Saito;Keisuke Morikawa

  • Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

    Heather P Harding;Marcella Calfon;Fumihiko Urano;Isabel Novoa

  • Measuring ER stress and the unfolded protein response using mammalian tissue culture system

    Christine M. Oslowski;Fumihiko Urano

  • Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

    Christine M. Oslowski;Takashi Hara;Takashi Hara;Takashi Hara;Bryan O'Sullivan-Murphy;Kohsuke Kanekura;Kohsuke Kanekura

  • Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

    Takunari Yoneda;Cristina Benedetti;Fumihiko Urano;Scott G. Clark

  • Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1

    Kathryn L. Lipson;Sonya G. Fonseca;Shinsuke Ishigaki;Linh X. Nguyen

  • Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation

    H. Kadowaki;H. Kadowaki;H. Nishitoh;H. Nishitoh;Fumihiko Urano;C. Sadamitsu

  • Endoplasmic reticulum stress and pancreatic β-cell death

    Sonya G. Fonseca;Jesper Gromada;Fumihiko Urano

  • Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

    Sonya G. Fonseca;Shinsuke Ishigaki;Christine M. Oslowski;Simin Lu

  • WFS1 Is a Novel Component of the Unfolded Protein Response and Maintains Homeostasis of the Endoplasmic Reticulum in Pancreatic β-Cells *

    Sonya G. Fonseca;Mariko Fukuma;Kathryn L. Lipson;Linh X. Nguyen

  • IRE1 and efferent signaling from the endoplasmic reticulum.

    Fumihiko Urano;A. Bertolotti;D. Ron

  • Male sterility and enhanced radiation sensitivity in TLS−/− mice

    Masahiko Kuroda;John Sok;Lisa Webb;Heidi Baechtold

  • Transcriptional regulation of VEGF-A by the unfolded protein response pathway

    Rajarshi Ghosh;Kathryn L. Lipson;Kathryn L. Lipson;Karen E. Sargent;Arthur M. Mercurio

  • Wolfram Syndrome: Diagnosis, Management, and Treatment.

    Fumihiko Urano

  • A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response

    Fumihiko Urano;Marcella Calfon;Takunari Yoneda;Chi Yun

  • Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions

    Shinsuke Ishigaki;Akio Masuda;Yusuke Fujioka;Yohei Iguchi

  • The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells

    Kathryn L. Lipson;Rajarshi Ghosh;Fumihiko Urano

  • Fluoride Induces Endoplasmic Reticulum Stress in Ameloblasts Responsible for Dental Enamel Formation

    Kaori Kubota;Daniel H. Lee;Masahiro Tsuchiya;Masahiro Tsuchiya;Masahiro Tsuchiya;Conan S. Young

Frequent Co-Authors

David Ron
David Ron University of Cambridge
Akihiro Umezawa
Akihiro Umezawa National Center For Child Health and Development
Dale L. Greiner
Dale L. Greiner University of Massachusetts Chan Medical School
Heather P. Harding
Heather P. Harding University of Cambridge
Lihua Julie Zhu
Lihua Julie Zhu University of Massachusetts Chan Medical School
Satoshi Inoue
Satoshi Inoue Saitama Medical University
David W. Piston
David W. Piston Washington University in St. Louis
Kazunori Imaizumi
Kazunori Imaizumi Hiroshima University
David M. Ornitz
David M. Ornitz Washington University in St. Louis
Gen Sobue
Gen Sobue Aichi Medical University

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