His primary areas of investigation include Computational biology, Genetics, Cas9, Genome editing and Signal transduction. His research in Computational biology intersects with topics in Annotation, DNA, Nuclease, Bioconductor and In vivo. His work in Gene, Zinc finger nuclease, Zebrafish, Locus and Caenorhabditis elegans are all subfields of Genetics research.
His work carried out in the field of Cas9 brings together such families of science as RNA and Subgenomic mRNA. His Signal transduction study is associated with Cell biology. His work in the fields of Cell biology, such as Unfolded protein response, intersects with other areas such as EIF-2 kinase.
His main research concerns Cell biology, Cancer research, Computational biology, Genetics and Transcription factor. His study explores the link between Cell biology and topics such as Chromatin that cross with problems in Epigenetics. His Cancer research research includes themes of Gene knockdown, Signal transduction, Kinase, MAPK/ERK pathway and Transforming growth factor.
Lihua Julie Zhu interconnects Genome editing, Genome, CRISPR, Annotation and Bioconductor in the investigation of issues within Computational biology. His Genome research integrates issues from Enhancer and Zebrafish. His Genetics study is mostly concerned with Gene and Alternative splicing.
Lihua Julie Zhu mostly deals with Cell biology, Gene, Computational biology, Transcription factor and Phenotype. In general Cell biology, his work in Erythropoietin receptor is often linked to Erythropoiesis linking many areas of study. Lihua Julie Zhu combines subjects such as Spermatogenic Cell and Embryo with his study of Gene.
His work deals with themes such as Bioconductor and Genome, which intersect with Computational biology. Lihua Julie Zhu has researched Transcription factor in several fields, including Wnt signaling pathway, Signal transduction, MAPK/ERK pathway, Mitochondrial unfolded protein response and Mitochondrion. His Phenotype study is concerned with the larger field of Genetics.
Cell biology, Gene, Enhancer, RNA-Seq and Cancer are his primary areas of study. His studies in Cell biology integrate themes in fields like Chromatin, Embryonic stem cell and Constitutive heterochromatin. When carried out as part of a general Gene research project, his work on Mutation, RNA and Point mutation is frequently linked to work in Fumarylacetoacetate hydrolase and Cisplatin, therefore connecting diverse disciplines of study.
His RNA-Seq research incorporates elements of Annotation, Genome, Ensembl and Zebrafish. His Genome study incorporates themes from Metadata, Computational biology and Accession number. His Cancer study combines topics in areas such as DNA replication, DNA, Homologous recombination, DNA repair and Programmed cell death.
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Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases
Xiangdong Meng;Marcus Blaine Noyes;Lihua Julie Zhu;Nathan D. Lawson.
Nature Biotechnology (2008)
ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data
Lihua Julie Zhu;Claude Gazin;Nathan D. Lawson;Herve Pages.
BMC Bioinformatics (2010)
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
Hao Yin;Chun-Qing Song;Joseph R. Dorkin;Lihua Julie Zhu.
Nature Biotechnology (2016)
Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome
Christine M. Oslowski;Takashi Hara;Takashi Hara;Takashi Hara;Bryan O'Sullivan-Murphy;Kohsuke Kanekura;Kohsuke Kanekura.
Cell Metabolism (2012)
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Hao Yin;Chun-Qing Song;Sneha Suresh;Qiongqiong Wu.
Nature Biotechnology (2017)
Annotating the human genome with Disease Ontology
John D. Osborne;Jared M. Flatow;Michelle Holko;Simon M. Lin.
BMC Genomics (2009)
Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.
Ankita Bansal;Lihua Julie Zhu;Kelvin Yen;Heidi A. Tissenbaum.
Proceedings of the National Academy of Sciences of the United States of America (2015)
Diet-Induced Developmental Acceleration Independent of TOR and Insulin in C. elegans
Lesley T. MacNeil;Emma Watson;H. Efsun Arda;Lihua Julie Zhu.
FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system
Lihua Julie Zhu;Ryan G. Christensen;Majid Kazemian;Christopher J. Hull.
Nucleic Acids Research (2011)
CRISPRseek: a bioconductor package to identify target-specific guide RNAs for CRISPR-Cas9 genome-editing systems.
Lihua Julie Zhu;Benjamin R. Holmes;Neil Aronin;Michael H. Brodsky.
PLOS ONE (2014)
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