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Genetics

D-Index
57
Citations
14085
World Ranking
3390
National Ranking
232

Overview

Toni Cathomen is affiliated with the University of Freiburg in Germany and has a research focus primarily in Biochemistry, Genetics, and Molecular Biology, with significant contributions also in Medicine. Their work spans a variety of subfields, including Molecular Biology, Immunology, Oncology, Genetics, and Epidemiology.

The research topics that feature prominently in their publications include:

  • CRISPR and Genetic Engineering
  • CAR-T cell therapy research
  • Virus-based gene therapy research
  • Immune Cell Function and Interaction
  • Viral Infectious Diseases and Gene Expression in Insects
  • Pluripotent Stem Cells Research
  • Cytomegalovirus and herpesvirus research

The scientist's frequently published work appears in key venues such as:

  • Molecular Therapy
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Nature Communications
  • Molecular Therapy - Nucleic Acids

Some selected recent papers authored or co-authored by Toni Cathomen include:

  • Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq, 2021, Cell Stem Cell
  • CRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myeloma, 2022, OncoImmunology
  • Automated generation of gene-edited CAR T cells at clinical scale, 2020, Molecular Therapy - Methods & Clinical Development
  • The potential of CAR T cell therapy for prostate cancer, 2021, Nature Reviews Urology
  • PSMA-Directed CAR T Cells Combined with Low-Dose Docetaxel Treatment Induce Tumor Regression in a Prostate Cancer Xenograft Model, 2020, Molecular Therapy - Oncolytics

Toni Cathomen has collaborated extensively with several co-authors, including:

  • Geoffroy Andrieux
  • Claudio Mussolino
  • Tatjana I. Cornu
  • Jamal Alzubi
  • Manuel Rhiel

Best Publications

  • A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

    Claudio Mussolino;Robert Morbitzer;Fabienne Lütge;Nadine Dannemann

  • Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.

    Morgan L. Maeder;Stacey Thibodeau-Beganny;Anna Osiak;David A. Wright

  • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.

    Desireé Schubert;Desireé Schubert;Claudia Bode;Rupert Kenefeck;Tie Zheng Hou

  • Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases.

    Michal Szczepek;Vincent Brondani;Janine Büchel;Luis Serrano

  • Unexpected failure rates for modular assembly of engineered zinc fingers

    Cherie L Ramirez;Jonathan E Foley;David A Wright;Felix Müller-Lerch

  • Zinc-finger Nucleases: The Next Generation Emerges

    Toni Cathomen;J Keith Joung

  • Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells

    Maarten Holkers;Ignazio Maggio;Jin Liu;Josephine M. Janssen

  • Measles Viruses with Altered Envelope Protein Cytoplasmic Tails Gain Cell Fusion Competence

    Toni Cathomen;Hussein Y. Naim;Roberto Cattaneo

  • A matrix-less measles virus is infectious and elicits extensive cell fusion: consequences for propagation in the brain

    Toni Cathomen;Branka Mrkic;Danièle Spehner;Robert Drillien

  • TALE nucleases: tailored genome engineering made easy.

    Claudio Mussolino;Toni Cathomen

  • DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases.

    Tatjana I Cornu;Stacey Thibodeau-Beganny;Eva Guhl;Stephen Alwin

  • Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome.

    Maximilian Müller;Ciaran M Lee;Ciaran M Lee;Giedrius Gasiunas;Timothy H Davis;Timothy H Davis

  • Refining strategies to translate genome editing to the clinic

    Tatjana I Cornu;Claudio Mussolino;Toni Cathomen

  • Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases

    Kristie Bloom;Abdullah Ely;Claudio Mussolino;Toni Cathomen

  • TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

    Claudio Mussolino;Jamal Alzubi;Eli J. Fine;Robert Morbitzer

  • Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

    Cherie L. Ramirez;Michael T. Certo;Claudio Mussolino;Mathew J. Goodwin

  • Custom Zinc-Finger Nucleases for Use in Human Cells

    Stephen Alwin;Maja B. Gere;Eva Guhl;Karin Effertz

  • Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro

    Jörg Schlender;Jens Jörg Schnorr;Pius Spielhofer;Toni Cathomen

  • Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks.

    Matthew H. Porteus;Toni Cathomen;Matthew D. Weitzman;David Baltimore

  • Adenoviral vector DNA for accurate genome editing with engineered nucleases

    Maarten Holkers;Ignazio Maggio;Sara F D Henriques;Josephine M Janssen

Frequent Co-Authors

J. Keith Joung
J. Keith Joung Harvard University
Axel Schambach
Axel Schambach Hannover Medical School
Matthew D. Weitzman
Matthew D. Weitzman Children's Hospital of Philadelphia
klaus schwarz
klaus schwarz University of Ulm
Roberto Cattaneo
Roberto Cattaneo Mayo Clinic
Matthew H. Porteus
Matthew H. Porteus Stanford University
Gang Bao
Gang Bao Rice University
David J. Segal
David J. Segal University of California, Davis
Daniel F. Voytas
Daniel F. Voytas University of Minnesota
Zoltán Ivics
Zoltán Ivics Paul Ehrlich Institut

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