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Biology and Biochemistry

D-Index
71
Citations
19030
World Ranking
6607
National Ranking
3076

Overview

Matthew D. Weitzman is affiliated with the Children's Hospital of Philadelphia in the United States. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, with 65 publications, and Medicine, contributing 32 publications. Within these broader fields, their work focuses on subfields such as Molecular Biology, Epidemiology, Genetics, Immunology, and Oncology.

The scientist's primary topics of research involve virus-based gene therapy research, RNA modifications and cancer, RNA research and splicing, interferon and immune responses, CRISPR and genetic engineering, herpesvirus infections and treatments, and CAR-T cell therapy research.

Their frequent coauthors include Katharina E. Hayer, Matthew Charman, Alexander M. Price, Benjamin A. García, and Joseph M. Dybas.

They have published regularly in well-known venues, including bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Viruses, Nature, and Human Gene Therapy.

Some recent notable papers include:

  • Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction (2020, Cancer Discovery)
  • Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing (2020, Nature Communications)
  • STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury (2020, Nature Cell Biology)
  • The HSV-1 ubiquitin ligase ICP0: Modifying the cellular proteome to promote infection (2020, Virus Research)
  • Adeno-Associated Virus Genome Interactions Important for Vector Production and Transduction (2020, Human Gene Therapy)

Best Publications

  • Global analysis of host-pathogen interactions that regulate early stage HIV-1 replication

    Renate König;Yingyao Zhou;Daniel Elleder;Tracy L. Diamond

  • GENE THERAPY: Twenty-First Century Medicine

    Inder M. Verma;Matthew D. Weitzman

  • Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis.

    K. J. Fisher;Guang-Ping Gao;M. D. Weitzman;R. Dematteo

  • Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

    Travis H. Stracker;Travis H. Stracker;Christian T. Carson;Christian T. Carson;Matthew D. Weitzman

  • The Mre11 complex is required for ATM activation and the G2/M checkpoint

    Christian T. Carson;Christian T. Carson;Rachel A. Schwartz;Rachel A. Schwartz;Travis H. Stracker;Travis H. Stracker;Travis H. Stracker;Caroline E. Lilley

  • The MRN complex in double‐strand break repair and telomere maintenance

    Brandon J. Lamarche;Nicole I. Orazio;Nicole I. Orazio;Matthew D. Weitzman

  • Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA

    Matthew D. Weitzman;Sirkka R. M. Kyostio;Robert M. Kotin;Roland A. Owens

  • Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors

    Oliver J Müller;Felix Kaul;Matthew D Weitzman;Renata Pasqualini

  • APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

    Hui Chen;Caroline E. Lilley;Qin Yu;Darwin V. Lee

  • Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure.

    V Doucas;A M Ishov;A Romo;H Juguilon

  • Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

    Manqing Li;Elaine Kao;Xia Gao;Hilary Sandig

  • Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy.

    Jonathan E. Loeb;Wendy S. Cordier;Matthew E. Harris;Matthew D. Weitzman

  • A Hybrid Vector for Ligand-Directed Tumor Targeting and Molecular Imaging

    Amin Hajitou;Martin Trepel;Caroline E. Lilley;Suren Soghomonyan

  • Incorporation of Tumor-Targeting Peptides into Recombinant Adeno-associated Virus Capsids

    Mirta Grifman;Martin Trepel;Paul Speece;Paul Speece;Luz Beatriz Gilbert

  • DNA repair proteins affect the lifecycle of herpes simplex virus 1

    Caroline E. Lilley;Christian T. Carson;Alysson R. Muotri;Fred H. Gage

  • APOBEC3A can activate the DNA damage response and cause cell‐cycle arrest

    Sébastien Landry;Iñigo Narvaiza;Daniel C Linfesty;Matthew D Weitzman

  • Differential L1 regulation in pluripotent stem cells of humans and apes

    Maria C. N. Marchetto;Iñigo Narvaiza;Ahmet M. Denli;Christopher Benner

  • Genomes in Conflict: Maintaining Genome Integrity During Virus Infection

    Matthew D Weitzman;Caroline E Lilley;Mira S Chaurushiya

  • Using or abusing: viruses and the cellular DNA damage response.

    Caroline E. Lilley;Rachel A. Schwartz;Rachel A. Schwartz;Matthew D. Weitzman

  • ADENOVIRUS MELHORADO E METODOS PARA A SUA UTILIZACAO

    Wilson James M;Fisher Krishna J;Shu-Jen Chen;Matthew Weitzman

Frequent Co-Authors

James M. Wilson
James M. Wilson University of Pennsylvania
Benjamin A. Garcia
Benjamin A. Garcia Washington University in St. Louis
Toni Cathomen
Toni Cathomen University of Freiburg
Carl H. June
Carl H. June University of Pennsylvania
Robert M. Kotin
Robert M. Kotin University of Massachusetts Chan Medical School
Renata Pasqualini
Renata Pasqualini University of New Mexico
Wadih Arap
Wadih Arap Rutgers, The State University of New Jersey
Olivier Michielin
Olivier Michielin University of Lausanne
David W. Kimberlin
David W. Kimberlin University of Alabama at Birmingham
Richard J. Whitley
Richard J. Whitley University of Alabama at Birmingham

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