Terence R. Flotte

Overview

Best Publications

• Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

  William W. Hauswirth;Tomas S. Aleman;Shalesh Kaushal;Artur V. Cideciyan

  1158
  Citations

• Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

  Artur V. Cideciyan;Tomas S. Aleman;Sanford L. Boye;Sharon B. Schwartz

  809
  Citations

• Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector.

  Terence R. Flotte;Sandra A. Afione;Carol Conrad;Sharon A. McGrath

  724
  Citations

• Mutational Analysis of the Adeno-Associated Virus Type 2 (AAV2) Capsid Gene and Construction of AAV2 Vectors with Altered Tropism

  Pei Wu;Wu Xiao;Thomas Conlon;Jeffrey Hughes

  537
  Citations

• Adeno-associated virus vectors for gene therapy

  T R Flotte;B J Carter

  529
  Citations

• VIRUS ADENO-ASSOCIADO COM SEQUENCIAS DA REPETICAO TERMINAL INVERTIDA COMO PROMOTOR PARA A TRANSFERENCIA IN VIVO DE UM GENE DE CFTR FUNCIONAL

  Carter Barrie J;Flotte Terrence;Afione Sandra;Solow Rikki

  517
  Citations

• Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR

  Marie Egan;Terence Flotte;Terence Flotte;Sandra Afione;Rikki Solow

  516
  Citations

• Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter

  Terence R. Flotte;Sandra A. Afione;Rikki Solow;Mitchell L. Drumm

  475
  Citations

• Clinical gene therapy using recombinant adeno-associated virus vectors

  Christian Mueller;Terence R. Flotte

  401
  Citations

• Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

  Mark L. Brantly;Jeffrey D. Chulay;Lili Wang;Christian Mueller

  392
  Citations

• Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results.

  Terence R. Flotte;Bruce C. Trapnell;Margaret Humphries;Brenna Carey

  392
  Citations

• Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors

  Sihong Song;Michael Morgan;Tamir Ellis;Amy Poirier

  363
  Citations

• A phase I study of an adeno-associated virus-CFTR gene vector in adult CF patients with mild lung disease

  Terence Flotte;Barrie Carter;Carol Conrad;William Guggino

  355
  Citations

• Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors

  A Donsante;C Vogler;N Muzyczka;JM Crawford

  350
  Citations

• In vivo model of adeno-associated virus vector persistence and rescue

  Sandra A. Afione;Carol K. Conrad;William G. Kearns;Suryaprabha Chunduru

  339
  Citations

• Phase I Trial of Intranasal and Endobronchial Administration of a Recombinant Adeno-Associated Virus Serotype 2 (rAAV2)-CFTR Vector in Adult Cystic Fibrosis Patients: A Two-Part Clinical Study

  Terence R. Flotte;Pamela L. Zeitlin;Thomas C. Reynolds;Alison E. Heald

  338
  Citations

• Gene Expression from Adeno-associated Virus Vectors in Airway Epithelial Cells

  Terence R. Flotte;Rikki Solow;Roland A. Owens;Sandra Afione

  338
  Citations

• α-1 Antitrypsin Inhibits Caspase-3 Activity, Preventing Lung Endothelial Cell Apoptosis

  Irina Petrache;Iwona Fijalkowska;Terry R. Medler;Jarrett Skirball

  333
  Citations

• Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integration.

  Terence R. Flotte;Sandra A. Afione;Pamela L. Zeitlin

  324
  Citations

• A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies.

  John A. Wagner;Ilynn B. Nepomuceno;Anna H. Messner;Mary Lynn Moran

  316
  Citations