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Molecular Biology

D-Index
43
Citations
6459
World Ranking
2984
National Ranking
1417

Overview

Christian Mueller is affiliated with Sanofi in the United States and has an extensive publication record in the fields of medicine and biochemistry, genetics, and molecular biology. Their research focus spans several subfields including molecular biology, genetics, neurology, epidemiology, and cancer research.

The scientist's main topics of work include:

  • Virus-based gene therapy research
  • Neurogenetic and muscular disorders research
  • Amyotrophic lateral sclerosis research
  • CAR-T cell therapy research
  • Protease and inhibitor mechanisms
  • RNA interference and gene delivery
  • Lysosomal storage disorders research

Christian Mueller has published significant papers such as:

  • SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS, 2020, New England Journal of Medicine
  • AAV gene therapy for Tay-Sachs disease, 2022, Nature Medicine
  • Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD, 2020, Molecular Neurodegeneration
  • CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro, 2022, Nature Communications
  • Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice, 2021, Proceedings of the National Academy of Sciences

The most frequent publication venues for Christian Mueller include:

  • Molecular Therapy
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Human Gene Therapy
  • Nature Communications
  • Proceedings of the National Academy of Sciences

Frequent co-authors in Christian Mueller's work are:

  • Gwladys Gernoux
  • Meghan Blackwood
  • Terence R. Flotte
  • Robert H. Brown
  • Martin Goulet

Best Publications

  • Several rAAV Vectors Efficiently Cross the Blood–brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System

    Hongwei Zhang;Bin Yang;Xin Mu;Xin Mu;Seemin Seher Ahmed

  • Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

    Owen Morgan Peters;Gabriela Toro Cabrera;Helene Tran;Tania F. Gendron

  • Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency

    Juergen Neesen;Renate Kirschner;Matthias Ochs;Andreas Schmiedl

  • MicroRNA-regulated, systemically delivered rAAV9: A step closer to CNS-restricted transgene expression

    Jun Xie;Qing Xie;Qing Xie;Hongwei Zhang;Stefan L Ameres

  • Lack of Cystic Fibrosis Transmembrane Conductance Regulator in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyperinflammatory Adaptive Immune Responses

    Christian Mueller;Sofia A. Braag;Allison M. Keeler;Craig Hodges

  • A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

    Julia F. Alterman;Bruno M. D. C. Godinho;Matthew R. Hassler;Chantal M. Ferguson

  • Recombinant AAV as a Platform for Translating the Therapeutic Potential of RNA Interference

    Florie Borel;Mark A Kay;Christian Mueller

  • Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles

    Christian Mueller;Qiushi Tang;Alisha Gruntman;Keith S. Blomenkamp

  • Immune responses in cystic fibrosis: are they intrinsically defective?

    Dmitry Ratner;Christian Mueller

  • Precise therapeutic gene correction by a simple nuclease-induced double-stranded break

    Sukanya Iyer;Sneha Suresh;Dongsheng Guo;Katelyn Daman

  • Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model.

    Lorelei Stoica;Sophia H. Todeasa;Gabriela Toro Cabrera;Johnny S. Salameh

  • Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors

    Shaoyong Li;Chen Ling;Li Zhong;Mengxin Li

  • Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease.

    Edith L Pfister;Natalie DiNardo;Erica Mondo;Florie Borel

  • In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA

    Pedro E Cruz;Christian Mueller;Travis L Cossette;Alexandra Golant

  • Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD

    Nadja S. Andrade;Melina Ramic;Rustam Esanov;Wenjun Liu

  • Gene therapy for cystic fibrosis.

    Christian Mueller;Terence R. Flotte

  • Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency.

    Florie Borel;Qiushi Tang;Gwladys Gernoux;Cynthia Greer

  • Dual Reporter Comparative Indexing of rAAV Pseudotyped Vectors in Chimpanzee Airway

    Terence R Flotte;Anne C Fischer;Jason Goetzmann;Christian Mueller

  • Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery.

    Rejean Liqun Wang;Thomas J. McLaughlin;Travis Cossette;Qiushi Tang

  • In Vivo Genome Editing Partially Restores Alpha1-Antitrypsin in a Murine Model of AAT Deficiency

    Chun-Qing Song;Dan Wang;Tingting Jiang;Kevin O'Connor

Frequent Co-Authors

Terence R. Flotte
Terence R. Flotte University of Massachusetts Chan Medical School
Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School
Robert H. Brown
Robert H. Brown University of Massachusetts Chan Medical School
James M. Wilson
James M. Wilson University of Pennsylvania
Martha Campbell-Thompson
Martha Campbell-Thompson University of Florida
Miguel Sena-Esteves
Miguel Sena-Esteves University of Massachusetts Chan Medical School
Roberto Calcedo
Roberto Calcedo Affinia Therapeutics
Neil Aronin
Neil Aronin University of Massachusetts Chan Medical School
Leonard D. Shultz
Leonard D. Shultz Jackson Laboratory
Marian DiFiglia
Marian DiFiglia Harvard University

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