Leonard D. Shultz mostly deals with Immunology, Stem cell, Nod, Immune system and Haematopoiesis. His Immunology research is multidisciplinary, incorporating elements of Severe combined immunodeficiency and Transplantation. His Stem cell research incorporates themes from Myeloid, Cancer research, Cord blood, Molecular biology and Leukemia.
His studies deal with areas such as Congenic, Adoptive cell transfer and Virology as well as Nod. His Immune system research integrates issues from Human leukocyte antigen and B cell. The study incorporates disciplines such as Interleukin, Macrophage colony-stimulating factor and Hematopoietic stem cell transplantation in addition to Haematopoiesis.
His primary areas of investigation include Immunology, Molecular biology, Immune system, Stem cell and Haematopoiesis. His Immunology research is multidisciplinary, relying on both Cancer research, Nod and Transplantation. His biological study spans a wide range of topics, including Macrophage colony-stimulating factor, Endocrinology, Mutant, B cell and Spleen.
His Immune system research includes themes of Antibody, Antigen and Virology. The Stem cell study combines topics in areas such as Leukemia and Cord blood. His research in Haematopoiesis intersects with topics in Myeloid, Hematopoietic stem cell transplantation and Cellular differentiation.
Immunology, Cancer research, Immune system, Humanized mouse and Stem cell are his primary areas of study. His research brings together the fields of Nod and Immunology. The various areas that he examines in his Cancer research study include Cancer, Leukemia, Cell growth and In vivo.
His Immune system research is multidisciplinary, incorporating perspectives in CD34 and Antibody. His Humanized mouse research focuses on Monoclonal antibody and how it relates to Virology. Many of his studies on Stem cell apply to Bone marrow as well.
His primary areas of study are Immunology, Immune system, Cancer research, Stem cell and Cell biology. His work on Immunology is being expanded to include thematically relevant topics such as Virology. He has included themes like Hematopoietic stem cell transplantation and Transplantation in his Immune system study.
His Cancer research research includes elements of Chemotherapy, Anaplastic large-cell lymphoma, Lymphoma, Pathology and Leukemia. His work in Leukemia addresses subjects such as Gene rearrangement, which are connected to disciplines such as Myeloid and Haematopoiesis. He interconnects Sarcoma, Bone marrow and Immunotherapy in the investigation of issues within Stem cell.
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The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
Hisahiro Yoshida;Shin Ichi Hayashi;Takahiro Kunisada;Minetaro Ogawa.
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
Amnon Peled;Isabelle Petit;Orit Kollet;Michal Magid.
Humanized mice in translational biomedical research
Leonard D. Shultz;Fumihiko Ishikawa;Dale L. Greiner.
Nature Reviews Immunology (2007)
The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
JM McCune;R Namikawa;H Kaneshima;LD Shultz.
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Leonard D. Shultz;Bonnie L. Lyons;Lisa M. Burzenski;Bruce Gott.
Journal of Immunology (2005)
Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
L D Shultz;P A Schweitzer;S W Christianson;B Gott.
Journal of Immunology (1995)
Humanized mice for immune system investigation: progress, promise and challenges.
Leonard D. Shultz;Michael A. Brehm;J. Victor Garcia-Martinez;Dale L. Greiner.
Nature Reviews Immunology (2012)
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.
Fumihiko Ishikawa;Shuro Yoshida;Yoriko Saito;Atsushi Hijikata.
Nature Biotechnology (2007)
Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice
Fumihiko Ishikawa;Masaki Yasukawa;Bonnie Lyons;Shuro Yoshida.
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.
Leonard D. Shultz;Peter A. Schweitzer;T.V. Rajan;Taolin Yi.
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