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Leonard D. Shultz

Leonard D. Shultz

D-Index & Metrics

Immunology

D-Index
125
Citations
59312
World Ranking
281
National Ranking
180

Medicine

D-Index
125
Citations
59472
World Ranking
3090
National Ranking
1707

Overview

Leonard D. Shultz is affiliated with Jackson Laboratory in the United States. Their research spans multiple fields, notably Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. The scientist's work focuses on areas including Immunology, Molecular Biology, Oncology, Genetics, and Hematology, with a significant emphasis on cancer and immune system interactions.

Their primary research topics include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Monoclonal and Polyclonal Antibodies Research
  • Pancreatic function and diabetes
  • Cancer Research and Treatments
  • Immune cells in cancer

Frequent co-authors collaborating with Leonard D. Shultz are:

  • Dale L. Greiner
  • Michael A. Brehm
  • James Keck
  • Mingshan Cheng
  • Li-Chin Yao

Their work has been published predominantly in the following venues:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • The FASEB Journal
  • The Journal of Immunology

Leonard D. Shultz has authored numerous papers, including recent notable publications such as:

  • "Humanized mouse models for immuno-oncology research", 2023, Nature Reviews Clinical Oncology
  • "Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis", 2020, Nature Immunology
  • "Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment", 2022, Immunity
  • "Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status", 2020, Nature Communications
  • "Innovations, challenges, and minimal information for standardization of humanized mice", 2020, EMBO Molecular Medicine

Best Publications

  • The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

    Hisahiro Yoshida;Shin Ichi Hayashi;Takahiro Kunisada;Minetaro Ogawa

  • Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

    Amnon Peled;Isabelle Petit;Orit Kollet;Michal Magid

  • Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.

    Leonard D. Shultz;Bonnie L. Lyons;Lisa M. Burzenski;Bruce Gott

  • Humanized mice in translational biomedical research

    Leonard D. Shultz;Fumihiko Ishikawa;Dale L. Greiner

  • The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.

    JM McCune;R Namikawa;H Kaneshima;LD Shultz

  • Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.

    L D Shultz;P A Schweitzer;S W Christianson;B Gott

  • Humanized mice for immune system investigation: progress, promise and challenges.

    Leonard D. Shultz;Michael A. Brehm;J. Victor Garcia-Martinez;Dale L. Greiner

  • Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.

    Fumihiko Ishikawa;Shuro Yoshida;Yoriko Saito;Atsushi Hijikata

  • Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice

    Fumihiko Ishikawa;Masaki Yasukawa;Bonnie Lyons;Shuro Yoshida

  • Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.

    Leonard D. Shultz;Peter A. Schweitzer;T.V. Rajan;Taolin Yi

  • T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

    Priti Kumar;Hong Seok Ban;Sang Soo Kim;Haoquan Wu

  • B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

    D V Serreze;H D Chapman;D S Varnum;M S Hanson

  • Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors.

    Sherri W Christianson;Leonard D Shultz;Edward H Leiter

  • Humanized Mouse Models of Clinical Disease.

    Nicole C. Walsh;Laurie L. Kenney;Sonal Jangalwe;Ken-Edwin Aryee

  • Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells

    Yoriko Saito;Hiroshi Kitamura;Atsushi Hijikata;Mariko Tomizawa-Murasawa

  • Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris

    Peter J. Koch;M G. Mahoney;Hiroyasu Ishikawa;Leena Pulkkinen

  • SCID Mouse Models of Human Stem Cell Engraftment

    Dale L. Greiner;RuthAnn M. Hesselton;Leonard D. Shultz

  • Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML

    Yoriko Saito;Naoyuki Uchida;Satoshi Tanaka;Nahoko Suzuki

  • Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.

    M A King;L Covassin;M A Brehm;W Racki

  • Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.

    Ramona Crescenzo;Ramona Crescenzo;Francesco Abate;Francesco Abate;Francesco Abate;Elena Lasorsa;Fabrizio Tabbo;Fabrizio Tabbo

  • Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness in Mast Cell–deficient Mice

    K. Takeda;E. Hamelmann;A. Joetham;L.D. Shultz

  • Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2rγnull Mice Engrafted with Mobilized Human Hematopoietic Stem Cells.

    Leonard Shultz;Bonnie L. Lyons;Lisa M. Burzenski;Bruce Gott

Frequent Co-Authors

Dale L. Greiner
Dale L. Greiner University of Massachusetts Chan Medical School
Michael A. Brehm
Michael A. Brehm University of Massachusetts Chan Medical School
Aldo A. Rossini
Aldo A. Rossini University of Massachusetts Chan Medical School
John P. Mordes
John P. Mordes University of Massachusetts Chan Medical School
Osamu Ohara
Osamu Ohara Chiba University
Koichi Akashi
Koichi Akashi Kyushu University
Mine Harada
Mine Harada Kyushu University
Alvin C. Powers
Alvin C. Powers Vanderbilt University Medical Center
John P. Sundberg
John P. Sundberg Vanderbilt University
David V. Serreze
David V. Serreze The Jackson Laboratory

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