World's Best Scientists 2026 revealed!

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Immunology

D-Index
111
Citations
47217
World Ranking
470
National Ranking
286

Medicine

D-Index
111
Citations
47259
World Ranking
5321
National Ranking
2872

Research.com Recognitions

  • 2004 - National Institutes of Health Director's Pioneer Award
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Joseph M. McCune is affiliated with the University of California, San Francisco in the United States. Their research primarily focuses on Immunology and Microbiology, with a significant body of work in Medicine. Key subfields include Immunology, Virology, Molecular Biology, Infectious Diseases, and Genetics.

Their recent scholarly output includes multiple publications related to HIV research and treatment as well as immune system function and interaction. Notable recent papers include:

  • The case for an HIV cure and how to get there, 2020, The Lancet HIV
  • Multi-stakeholder consensus on a target product profile for an HIV cure, 2020, The Lancet HIV
  • TCF-1 regulates HIV-specific CD8+ T cell expansion capacity, 2020, JCI Insight
  • European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance, 2021, Annals of the Rheumatic Diseases
  • Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities, 2020, Annals of the Rheumatic Diseases

The scientist has collaborated extensively, with frequent co-authors including:

  • Sharon R. Lewin
  • Steven G. Deeks
  • Rachel L. Rutishauser
  • Peter W. Hunt
  • David M. Margolis

Joseph M. McCune's publications are found across various venues, notably:

  • UNC Libraries
  • The Lancet HIV
  • Cell Reports
  • JCI Insight
  • Annals of the Rheumatic Diseases

The researcher's work covers several main topics, including:

  • HIV Research and Treatment
  • CRISPR and Genetic Engineering
  • Immune Cell Function and Interaction
  • HIV/AIDS Research and Interventions
  • T-cell and B-cell Immunology
  • HIV/AIDS drug development and treatment
  • Immune responses and vaccinations

Joseph M. McCune has received recognition in the form of the National Institutes of Health Director's Pioneer Award in 2004. They are also a Member of the Association of American Physicians.

Best Publications

  • 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus

    Martin Aringer;Karen Costenbader;David Daikh;Ralph Brinks

  • The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes

    Matthew H. Liang;Michael Corzillius;Sang Cheol Bae;Robert A. Lew

  • The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.

    JM McCune;R Namikawa;H Kaneshima;LD Shultz

  • Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero

    Jeff E. Mold;Jakob Michaëlsson;Trevor D. Burt;Marcus O. Muench

  • Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

    R. Brad Jones;Lishomwa C Ndhlovu;Jason D. Barbour;Prameet M. Sheth

  • Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia.

    Steven G. Deeks;Terri Wrin;Teri Liegler;Rebecca Hoh

  • Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus

    Joseph M. McCune;Linda B. Rabin;Mark B. Feinberg;Miriam Lieberman

  • Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

    Ivan Vujkovic-Cvijin;Richard M. Dunham;Shoko Iwai;Michael C. Maher

  • The dynamics of CD4 + T-cell depletion in HIV disease

    Joseph M. McCune

  • Relationship between T Cell Activation and CD4+ T Cell Count in HIV-Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy

    Peter W. Hunt;Jason Brenchley;Elizabeth Sinclair;Joseph M. McCune

  • Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans

    M Hellerstein;M B Hanley;D Cesar;S Siler

  • HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.

    Sergio Serrano-Villar;Talia Sainz;Sulggi A. Lee;Peter W. Hunt

  • Immune mechanisms at the maternal-fetal interface: perspectives and challenges

    Mercy PrabhuDas;Elizabeth Bonney;Kathleen Caron;Sudhansu Dey

  • Increased production of IL-7 accompanies HIV-1–mediated T-cell depletion: implications for T-cell homeostasis

    Laura A. Napolitano;Robert M. Grant;Steven G. Deeks;Diane Schmidt

  • Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.

    David Favre;Jeff Mold;Peter W. Hunt;Bittoo Kanwar

  • Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1

    Krishna V. Komanduri;Mohan N. Viswanathan;Eric D. Wieder;Diane K. Schmidt

  • Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells.

    Dennis J. Hartigan-O'Connor;Chungkee Poon;Elizabeth Sinclair;Joseph M. McCune

  • HIV induces thymus depletion in vivo.

    Mark L. Bonyhadi;Linda Rabin;Suzan Salimi;Daniel A. Brown

  • Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.

    David Favre;Sharon Lederer;Bittoo Kanwar;Zhong Min Ma

  • International AIDS Society global scientific strategy: towards an HIV cure 2016

    Steven G Deeks;Sharon R Lewin;Anna Laura Ross;Jintanat Ananworanich

  • Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans

    Jeff E. Mold;Shivkumar Venkatasubrahmanyam;Trevor D. Burt;Jakob Michaëlsson

  • Use of overlapping peptide mixtures as antigens for cytokine flow cytometry

    Holden T Maecker;Holli S Dunn;Maria A Suni;Elham Khatamzas;Elham Khatamzas

Frequent Co-Authors

Steven G. Deeks
Steven G. Deeks University of California, San Francisco
Jeffrey N. Martin
Jeffrey N. Martin University of California, San Francisco
Peter W. Hunt
Peter W. Hunt University of California, San Francisco
Elizabeth Sinclair
Elizabeth Sinclair University of California, San Francisco
Rebecca Hoh
Rebecca Hoh University of California, San Francisco
Michael P. Busch
Michael P. Busch University of California, San Francisco
Frederick Hecht
Frederick Hecht University of California, San Francisco
Douglas F. Nixon
Douglas F. Nixon Cornell University
Marc K. Hellerstein
Marc K. Hellerstein University of California, Berkeley
Irving L. Weissman
Irving L. Weissman Stanford University

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