Daniel C. Douek

Overview

Best Publications

• CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract

  Jason M. Brenchley;Timothy W. Schacker;Laura E. Ruff;David A. Price

  2498
  Citations

• A human memory T cell subset with stem cell-like properties

  Luca Gattinoni;Enrico Lugli;Yun Ji;Zoltan Pos

  2179
  Citations

• Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

  Michael R. Betts;Jason M. Brenchley;David A. Price;Stephen C. De Rosa

  2007
  Citations

• HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

  Nicolas Chomont;Mohamed El-Far;Petronela Ancuta;Lydie Trautmann

  2004
  Citations

• Impaired T H 17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

  Joshua D. Milner;Jason M. Brenchley;Jason M. Brenchley;Arian Laurence;Alexandra F. Freeman

  1653
  Citations

• Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

  Netanya Sandler;Handan Wand;Annelys Roque;Matthew G Law

  1322
  Citations

• Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

  Jason M. Brenchley;Nitin J. Karandikar;Michael R. Betts;David R. Ambrozak

  1271
  Citations

• PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

  Alena Gros;Paul F. Robbins;Xin Yao;Yong F. Li

  1197
  Citations

• PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.

  Constantinos Petrovas;Joseph P. Casazza;Jason M. Brenchley;David A. Price

  1130
  Citations

• Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

  T M Wilkinson;Li Ckf.;Chui Csc.;Huang Aky.;Huang Aky.

  1124
  Citations

• An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

  Ivona Aksentijevich;Seth L. Masters;Polly J. Ferguson;Paul Dancey

  1090
  Citations

• Systemic Effects of Inflammation on Health during Chronic HIV Infection

  Steven G. Deeks;Russell Tracy;Daniel C. Douek

  938
  Citations

• Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection

  Michael R. Betts;David R. Ambrozak;Daniel C. Douek;Sebastian Bonhoeffer

  887
  Citations

• Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

  Jorge R. Almeida;David A. Price;David A. Price;Laura Papagno;Zaïna Aït Arkoub

  885
  Citations

• Emerging Concepts in the Immunopathogenesis of AIDS

  Daniel C. Douek;Mario Roederer;Richard A. Koup

  878
  Citations

• T Cell Dynamics in HIV-1 Infection*

  Daniel C. Douek;Louis J. Picker;Richard A. Koup

  832
  Citations

• Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

  Jason M. Brenchley;Mirko Paiardini;Kenneth S. Knox;Kenneth S. Knox;Ava I. Asher

  813
  Citations

• Relationship between T Cell Activation and CD4+ T Cell Count in HIV-Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy

  Peter W. Hunt;Jason Brenchley;Elizabeth Sinclair;Joseph M. McCune

  809
  Citations

• Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

  Courtney V. Fletcher;Kathryn Staskus;Stephen W. Wietgrefe;Meghan Rothenberger

  740
  Citations

• Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

  Feng-Yen Li;Benjamin Chaigne-Delalande;Chrysi Kanellopoulou;Jeremiah C. Davis

  664
  Citations

• Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.

  David Favre;Jeff Mold;Peter W. Hunt;Bittoo Kanwar

  606
  Citations