2026 Richard A. Koup: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	146	133	124	89	82	531	93433
Medicine	146	1323	1222	764	694	530	93366

Research.com Recognitions

2026 - Research.com Immunology in United States Leader Award
2025 - Research.com Immunology in United States Leader Award
Member of the Association of American Physicians
Member of the Association of American Physicians
Member of the Association of American Physicians
Member of the Association of American Physicians

Overview

Richard A. Koup is affiliated with the National Institute of Allergy and Infectious Diseases in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on Infectious Diseases, Immunology, Virology, Epidemiology, and Radiology, Nuclear Medicine and Imaging.

Their work covers a range of main topics related to immunology and infectious disease control, including:

HIV Research and Treatment
SARS-CoV-2 and COVID-19 Research
Immune Cell Function and Interaction
Immunotherapy and Immune Responses
T-cell and B-cell Immunology
Monoclonal and Polyclonal Antibodies Research
COVID-19 Clinical Research Studies

The scientist has contributed to multiple publication venues, frequently publishing in:

bioRxiv (Cold Spring Harbor Laboratory)
Nature Communications
The Journal of Immunology
Nature Medicine
Science Translational Medicine

Notable recent papers authored or co-authored by Richard A. Koup include the following:

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial (2022), Science
Vaccination induces HIV broadly neutralizing antibody precursors in humans (2022), Science
A Covid-19 Milestone Attained - A Correlate of Protection for Vaccines (2022), New England Journal of Medicine
Defining the risk of SARS-CoV-2 variants on immune protection (2022), Nature
Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice (2022), Nature Medicine

Frequent collaborators in research include:

Adrian B. McDermott
John R. Mascola
Peter D. Kwong
Nicole A. Doria-Rose
Amarendra Pegu

Richard A. Koup has also been recognized as a Member of the Association of American Physicians.

Best Publications

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.

Tatjana Dragic;Virginia Litwin;Graham P. Allaway;Scott R. Martin

4323
Citations
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome.

R. A. Koup;J. T. Safrit;Yunzhen Cao;C. A. Andrews

3955
Citations
Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

Rong Liu;William A Paxton;Sunny Choe;Daniel Ceradini

3943
Citations
Changes in thymic function with age and during the treatment of HIV infection

Daniel C. Douek;Richard D. McFarland;Phillip H. Keiser;Earl A. Gage

2327
Citations
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells

Michael R. Betts;Martha C. Nason;Sadie M. West;Stephen C. De Rosa

2278
Citations
Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

Barton F. Haynes;Peter B. Gilbert;M. Juliana McElrath;Susan Zolla-Pazner

2118
Citations
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

Michael R. Betts;Jason M. Brenchley;David A. Price;Stephen C. De Rosa

2007
Citations
Genotypic and phenotypic characterization of HIV-1 patients with primary infection

Tuofu Zhu;Hongmei Mo;Ning Wang;Daniel S. Nam

1898
Citations
The role of a mutant CCR5 allele in HIV–1 transmission and disease progression

Yaoxing Huang;William A. Paxton;Steven M. Wolinsky;Avidan U. Neumann

1772
Citations
HIV preferentially infects HIV-specific CD4 + T cells

Daniel C. Douek;Jason M. Brenchley;Michael R. Betts;David R. Ambrozak

1720
Citations
Antiretroviral-Drug Resistance among Patients Recently Infected with HIV

Susan J. Little;Sarah Holte;Jean Pierre Routy;Eric S. Daar

1565
Citations
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

Jason M. Brenchley;Nitin J. Karandikar;Michael R. Betts;David R. Ambrozak

1271
Citations
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.

Constantinos Petrovas;Joseph P. Casazza;Jason M. Brenchley;David A. Price

1130
Citations
Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial.

Peter B Gilbert;Peter B Gilbert;David C Montefiori;Adrian B McDermott;Youyi Fong

1096
Citations
HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression.

Christine J. Pitcher;Claudia Quittner;Dolores M. Peterson;Mark Connors

942
Citations
Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection

Michael R. Betts;David R. Ambrozak;Daniel C. Douek;Sebastian Bonhoeffer

887
Citations
CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

Lijun Wu;William A. Paxton;Nasim Kassam;Nancy Ruffing

883
Citations
Emerging Concepts in the Immunopathogenesis of AIDS

Daniel C. Douek;Mario Roederer;Richard A. Koup

878
Citations
Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques.

Alexander I. Spira;Preston A. Marx;Bruce K. Patterson;James Mahoney

875
Citations
Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure.

William A. Paxton;Scott R. Martin;Doris Tse;Thomas R. O'Brien

851
Citations
T Cell Dynamics in HIV-1 Infection*

Daniel C. Douek;Louis J. Picker;Richard A. Koup

832
Citations

Frequent Co-Authors

Mario Roederer National Institute of Allergy and Infectious Diseases

Robert T. Bailer National Institute of Allergy and Infectious Diseases

Barney S. Graham Morehouse School of Medicine

John R. Mascola ModeX Therapeutics

Daniel C. Douek National Institute of Allergy and Infectious Diseases

Gary J. Nabel ModeX Therapeutics

Julie E. Ledgerwood National Institute of Allergy and Infectious Diseases

Adrian B. McDermott National Institute of Allergy and Infectious Diseases

Michael R. Betts University of Pennsylvania

Karin Loré Karolinska Institute

External Links

Personal website of Richard A. Koup

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