What is he best known for?
The fields of study he is best known for:
- Enzyme
- Alzheimer's disease
- Biochemistry
William L. Klein spends much of his time researching Alzheimer's disease, Neuroscience, Amyloid, Synapse and Biochemistry.
His studies in Alzheimer's disease integrate themes in fields like Hippocampal formation and Immunology.
His Neuroscience research incorporates elements of In vivo, Tau pathology and Pathogenesis.
He has included themes like Amyloid beta, Peptide, Antibody, Genetically modified mouse and Surface plasmon resonance in his Amyloid study.
His Synapse research is multidisciplinary, incorporating perspectives in Neuropathology, Dementia, Disease and Insulin receptor.
The study incorporates disciplines such as Immunofluorescence and Cell biology in addition to Biochemistry.
His most cited work include:
- Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins (3068 citations)
- Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss (969 citations)
- Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease (942 citations)
What are the main themes of his work throughout his whole career to date?
William L. Klein mainly investigates Cell biology, Biochemistry, Neuroscience, Alzheimer's disease and Amyloid.
The various areas that William L. Klein examines in his Cell biology study include Endocrinology, Receptor, Internal medicine, Muscarinic acetylcholine receptor and Neurite.
His Biochemistry study combines topics from a wide range of disciplines, such as Hippocampal formation, Amyloid β and Antibody.
His study looks at the relationship between Neuroscience and fields such as Long-term potentiation, as well as how they intersect with chemical problems.
In his research on the topic of Alzheimer's disease, Amyloid precursor protein is strongly related with Genetically modified mouse.
His Amyloid research is multidisciplinary, relying on both Biophysics and Human brain.
He most often published in these fields:
- Cell biology (28.81%)
- Biochemistry (24.69%)
- Neuroscience (22.63%)
What were the highlights of his more recent work (between 2012-2021)?
- Neuroscience (22.63%)
- Synapse (14.40%)
- Alzheimer's disease (18.52%)
In recent papers he was focusing on the following fields of study:
The scientist’s investigation covers issues in Neuroscience, Synapse, Alzheimer's disease, Cell biology and Amyloid.
His Synapse research integrates issues from Liraglutide, Endocrinology, Amyloid beta, Insulin receptor and Internal medicine.
His Alzheimer's disease research is under the purview of Pathology.
His research integrates issues of Biochemistry, Neuron, Single-Chain Variable Fragment Antibody and Aβ oligomers in his study of Cell biology.
His biological study spans a wide range of topics, including Neurotoxicity and Amyloid β.
His Amyloid study integrates concerns from other disciplines, such as Toxicity, Amyloid precursor protein and Pharmacology.
Between 2012 and 2021, his most popular works were:
- Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness (498 citations)
- Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis (284 citations)
- TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys (227 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Alzheimer's disease
- Biochemistry
William L. Klein focuses on Alzheimer's disease, Pathology, Neuroscience, Synapse and Amyloid precursor protein.
His work carried out in the field of Alzheimer's disease brings together such families of science as Hippocampus, Unfolded protein response, Genetically modified mouse, Pharmacology and Amyloid.
William L. Klein works in the field of Neuroscience, focusing on Hippocampal formation in particular.
His work is dedicated to discovering how Hippocampal formation, Type 2 diabetes are connected with Neuroprotection and other disciplines.
He interconnects Endocrinology, Insulin receptor and Internal medicine in the investigation of issues within Synapse.
As a member of one scientific family, William L. Klein mostly works in the field of Long-term potentiation, focusing on Neurotoxicity and, on occasion, Cell biology.
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