World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
88
Citations
41588
World Ranking
1176
National Ranking
603

Biology and Biochemistry

D-Index
88
Citations
41769
World Ranking
2640
National Ranking
1374

Research.com Recognitions

  • 2010 - Fellow of American Physical Society (APS) Citation For seminal contributions in the physics of nucleation and phase transitions arising from fundamental advances in statistical fieldtheoretic techniques, and their application to general mean field systems
  • 1989 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1968 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

William L. Klein is a researcher affiliated with Northwestern University in the United States. Their work primarily spans the fields of Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Physiology, Neurology, Molecular Biology, Cellular and Molecular Neuroscience, and Cell Biology.

The scientist's research topics encompass Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, neuroscience and neuropharmacology research, computational drug discovery methods, cholinesterase and neurodegenerative diseases, dementia and cognitive impairment research, and tryptophan and brain disorders.

Notable recent papers by William L. Klein include:

  • Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain, 2020, Proceedings of the National Academy of Sciences
  • Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease, 2022, Nature Communications
  • Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability, 2020, Neuropathology and Applied Neurobiology
  • Induction of inverted morphology in brain organoids by vertical-mixing bioreactors, 2021, Communications Biology
  • The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer's Disease, 2022, Frontiers in Neuroscience

Frequent co-authors collaborating with William L. Klein include Kirsten L. Viola, Maíra A. Bicca, Andre L.B. Bitencourt, Erika N. Cline, and Adriano Sebollela.

The scientist's publications appear predominantly in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Neuropathology and Applied Neurobiology
  • International Journal of Molecular Sciences
  • Alzheimer s & Dementia Translational Research & Clinical Interventions

William L. Klein has been recognized with several awards, including fellowships in prestigious organizations. These include being named a Fellow of the American Physical Society in 2010, cited for contributions in the physics of nucleation and phase transitions through statistical field-theoretic techniques, and two separate appointments as Fellow of the American Association for the Advancement of Science in 1968 and 1989.

Best Publications

  • Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins

    M. P. Lambert;A. K. Barlow;B. A. Chromy;C. Edwards

  • Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

    Pascale N. Lacor;Maria C. Buniel;Paul W. Furlow;Antonio Sanz Clemente

  • Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

    Yuesong Gong;Lei Chang;Kirsten L. Viola;Pascale N. Lacor

  • Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

    William L Klein;Grant A Krafft;Caleb E Finch

  • Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

    Pascale N. Lacor;Maria C. Buniel;Lei Chang;Sara J. Fernandez

  • Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor.

    Amanda J Haes;Lei Chang;William L Klein;Richard P Van Duyne

  • Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

    Fernanda G. De Felice;Fernanda G. De Felice;Pauline T. Velasco;Mary P. Lambert;Kirsten L. Viola

  • Nanoparticle-Based Detection in Cerebral Spinal Fluid of a Soluble Pathogenic Biomarker for Alzheimer’s Disease*

    Dimitra G. Georganopoulou;Lei Chang;Jwa Min Nam;C. Shad Thaxton

  • A Localized Surface Plasmon Resonance Biosensor: First Steps toward an Assay for Alzheimer's Disease

    Amanda J. Haes;W. Paige Hall;Lei Chang;William L. Klein

  • An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

    Theresa R. Bomfim;Leticia Forny-Germano;Luciana B. Sathler;Jordano Brito-Moreira

  • Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

    Takayuki Kondo;Masashi Asai;Masashi Asai;Kayoko Tsukita;Yumiko Kutoku

  • Aβ toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets

    William L Klein

  • The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

    Erika N. Cline;Maíra Assunção Bicca;Kirsten L. Viola;William L. Klein

  • Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

    Fernanda G. De Felice;Marcelo N.N. Vieira;Theresa R. Bomfim;Helena Decker

  • Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus

    Hai Wei Wang;Joseph F. Pasternak;Joseph F. Pasternak;Helen Kuo;Helen Ristic

  • Amyloid beta oligomers induce impairment of neuronal insulin receptors

    Wei Qin Zhao;Fernanda G. De Felice;Sara Fernandez;Hui Chen

  • Self-assembly of Aβ1-42 into globular neurotoxins

    Brett A. Chromy;Richard J. Nowak;Mary P. Lambert;Kirsten L. Viola

  • Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

    Kirsten L. Viola;William L. Klein

  • Cholesterol Modulates α-Secretase Cleavage of Amyloid Precursor Protein

    Steven Bodovitz;William L. Klein

  • Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

    Fernanda G. De Felice;Diana Wu;Mary P. Lambert;Sara J. Fernandez

Frequent Co-Authors

Fernanda G. De Felice
Fernanda G. De Felice Queen's University
Sergio T. Ferreira
Sergio T. Ferreira Federal University of Rio de Janeiro
Caleb E. Finch
Caleb E. Finch University of Southern California
Douglas P. Munoz
Douglas P. Munoz Queen's University
Vinayak P. Dravid
Vinayak P. Dravid Northwestern University
Charles G. Glabe
Charles G. Glabe University of California, Irvine
Stephen G. Sligar
Stephen G. Sligar University of Illinois at Urbana-Champaign
Christian Hölscher
Christian Hölscher Henan University
A. Claudio Cuello
A. Claudio Cuello McGill University
Michelle E. Ehrlich
Michelle E. Ehrlich Icahn School of Medicine at Mount Sinai

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