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William L. Klein

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
41769
World Ranking
2640
National Ranking
1374

Neuroscience

D-Index
88
Citations
41588
World Ranking
1176
National Ranking
603

William L. Klein publication distribution in Neuroscience in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Neuroscience in 2026. The highlighted bar marks where William L. Klein sits on this spectrum.

38–47 publications: 18 scientists 48–57 publications: 79 scientists 58–67 publications: 193 scientists 68–77 publications: 323 scientists 78–87 publications: 406 scientists 88–97 publications: 452 scientists 98–107 publications: 539 scientists 108–117 publications: 505 scientists 118–127 publications: 522 scientists 128–137 publications: 469 scientists 138–147 publications: 456 scientists 148–157 publications: 459 scientists 158–167 publications: 397 scientists 168–177 publications: 383 scientists 178–187 publications: 350 scientists 188–197 publications: 302 scientists 198–207 publications: 306 scientists 208–217 publications: 262 scientists 218–227 publications: 242 scientists 228–237 publications: 220 scientists 238–247 publications: 203 scientists 248–257 publications: 174 scientists 258–267 publications: 176 scientists 268–277 publications: 175 scientists 278–287 publications: 125 scientists 288–297 publications: 116 scientists 298–307 publications: 127 scientists 308–317 publications: 128 scientists 318–327 publications: 99 scientists 328–337 publications: 89 scientists 338–347 publications: 78 scientists 348–357 publications: 96 scientists 358–367 publications: 66 scientists 368–377 publications: 59 scientists 378–387 publications: 65 scientists 388–397 publications: 54 scientists 398–407 publications: 48 scientists 408–417 publications: 49 scientists 418–427 publications: 34 scientists 428–437 publications: 31 scientists 438–447 publications: 30 scientists 448–457 publications: 31 scientists 458–467 publications: 36 scientists 468–477 publications: 40 scientists 478–487 publications: 35 scientists 488–497 publications: 30 scientists 498–507 publications: 23 scientists 508–517 publications: 26 scientists 518–527 publications: 20 scientists 528–537 publications: 23 scientists 538–547 publications: 20 scientists 548–557 publications: 20 scientists 558–567 publications: 17 scientists 568–577 publications: 14 scientists 578–587 publications: 20 scientists 588–597 publications: 20 scientists 598–607 publications: 19 scientists 608–617 publications: 18 scientists 618–627 publications: 17 scientists 628–637 publications: 11 scientists 638–647 publications: 11 scientists 648–657 publications: 11 scientists 658–667 publications: 8 scientists 668–677 publications: 7 scientists 678–687 publications: 11 scientists 688–697 publications: 10 scientists 698–707 publications: 4 scientists 708–717 publications: 6 scientists 718–727 publications: 5 scientists 728–737 publications: 5 scientists 738–747 publications: 9 scientists 748–757 publications: 9 scientists 758–767 publications: 3 scientists 768–777 publications: 7 scientists 778–787 publications: 7 scientists 788–797 publications: 6 scientists 798–807 publications: 2 scientists 808–817 publications: 2 scientists 818–827 publications: 7 scientists 828–837 publications: 0 scientists 838–847 publications: 9 scientists 848–857 publications: 3 scientists 858–867 publications: 1 scientists 868–877 publications: 3 scientists 878–886 publications: 6 scientists 887+ publications: 100 scientists
38 publications 887+

This scientist: 261 publications — 76th percentile

76% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 887 publications or more.

William L. Klein D-index placement in Neuroscience in 2026

The chart shows the D-index (discipline H-index) distribution of Neuroscience scientists ranked by Research.com in 2026. The highlighted bar marks where William L. Klein sits on this spectrum.

30–31 D-Index: 42 scientists 32–33 D-Index: 172 scientists 34–35 D-Index: 296 scientists 36–37 D-Index: 435 scientists 38–39 D-Index: 459 scientists 40–41 D-Index: 456 scientists 42–43 D-Index: 467 scientists 44–45 D-Index: 478 scientists 46–47 D-Index: 512 scientists 48–49 D-Index: 435 scientists 50–51 D-Index: 425 scientists 52–53 D-Index: 418 scientists 54–55 D-Index: 392 scientists 56–57 D-Index: 357 scientists 58–59 D-Index: 334 scientists 60–61 D-Index: 328 scientists 62–63 D-Index: 260 scientists 64–65 D-Index: 278 scientists 66–67 D-Index: 239 scientists 68–69 D-Index: 250 scientists 70–71 D-Index: 210 scientists 72–73 D-Index: 200 scientists 74–75 D-Index: 189 scientists 76–77 D-Index: 170 scientists 78–79 D-Index: 146 scientists 80–81 D-Index: 113 scientists 82–83 D-Index: 126 scientists 84–85 D-Index: 100 scientists 86–87 D-Index: 84 scientists 88–89 D-Index: 99 scientists 90–91 D-Index: 84 scientists 92–93 D-Index: 85 scientists 94–95 D-Index: 72 scientists 96–97 D-Index: 76 scientists 98–99 D-Index: 45 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 43 scientists 104–105 D-Index: 32 scientists 106–107 D-Index: 45 scientists 108–109 D-Index: 50 scientists 110–111 D-Index: 32 scientists 112–113 D-Index: 39 scientists 114–115 D-Index: 32 scientists 116–117 D-Index: 29 scientists 118–119 D-Index: 27 scientists 120–121 D-Index: 19 scientists 122–123 D-Index: 23 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 16 scientists 128–129 D-Index: 24 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 21 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 14 scientists 138–139 D-Index: 15 scientists 140–141 D-Index: 10 scientists 142–143 D-Index: 10 scientists 144–145 D-Index: 13 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 8 scientists 150–151 D-Index: 6 scientists 152–153 D-Index: 6 scientists 154–155 D-Index: 7 scientists 156–157 D-Index: 7 scientists 158–159 D-Index: 10 scientists 160–161 D-Index: 4 scientists 162 D-Index: 8 scientists 163+ D-Index: 100 scientists
30 D-Index 163+

This scientist: 88 D-Index — 88th percentile

88% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 163 D-Index or more.

Research.com Recognitions

  • 2010 - Fellow of American Physical Society (APS) Citation For seminal contributions in the physics of nucleation and phase transitions arising from fundamental advances in statistical fieldtheoretic techniques, and their application to general mean field systems
  • 1989 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1968 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

William L. Klein is a researcher affiliated with Northwestern University in the United States. Their work primarily spans the fields of Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Physiology, Neurology, Molecular Biology, Cellular and Molecular Neuroscience, and Cell Biology.

The scientist's research topics encompass Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, neuroscience and neuropharmacology research, computational drug discovery methods, cholinesterase and neurodegenerative diseases, dementia and cognitive impairment research, and tryptophan and brain disorders.

Notable recent papers by William L. Klein include:

  • Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain, 2020, Proceedings of the National Academy of Sciences
  • Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease, 2022, Nature Communications
  • Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability, 2020, Neuropathology and Applied Neurobiology
  • Induction of inverted morphology in brain organoids by vertical-mixing bioreactors, 2021, Communications Biology
  • The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer's Disease, 2022, Frontiers in Neuroscience

Frequent co-authors collaborating with William L. Klein include Kirsten L. Viola, Maíra A. Bicca, Andre L.B. Bitencourt, Erika N. Cline, and Adriano Sebollela.

The scientist's publications appear predominantly in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Neuropathology and Applied Neurobiology
  • International Journal of Molecular Sciences
  • Alzheimer s & Dementia Translational Research & Clinical Interventions

William L. Klein has been recognized with several awards, including fellowships in prestigious organizations. These include being named a Fellow of the American Physical Society in 2010, cited for contributions in the physics of nucleation and phase transitions through statistical field-theoretic techniques, and two separate appointments as Fellow of the American Association for the Advancement of Science in 1968 and 1989.

Best Publications

  • Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins

    M. P. Lambert;A. K. Barlow;B. A. Chromy;C. Edwards

  • Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

    Pascale N. Lacor;Maria C. Buniel;Paul W. Furlow;Antonio Sanz Clemente

  • Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

    Yuesong Gong;Lei Chang;Kirsten L. Viola;Pascale N. Lacor

  • Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

    William L Klein;Grant A Krafft;Caleb E Finch

  • Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

    Pascale N. Lacor;Maria C. Buniel;Lei Chang;Sara J. Fernandez

  • Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor.

    Amanda J Haes;Lei Chang;William L Klein;Richard P Van Duyne

  • Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

    Fernanda G. De Felice;Fernanda G. De Felice;Pauline T. Velasco;Mary P. Lambert;Kirsten L. Viola

  • Nanoparticle-Based Detection in Cerebral Spinal Fluid of a Soluble Pathogenic Biomarker for Alzheimer’s Disease*

    Dimitra G. Georganopoulou;Lei Chang;Jwa Min Nam;C. Shad Thaxton

  • A Localized Surface Plasmon Resonance Biosensor: First Steps toward an Assay for Alzheimer's Disease

    Amanda J. Haes;W. Paige Hall;Lei Chang;William L. Klein

  • An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

    Theresa R. Bomfim;Leticia Forny-Germano;Luciana B. Sathler;Jordano Brito-Moreira

  • Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

    Takayuki Kondo;Masashi Asai;Masashi Asai;Kayoko Tsukita;Yumiko Kutoku

  • Aβ toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets

    William L Klein

  • The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

    Erika N. Cline;Maíra Assunção Bicca;Kirsten L. Viola;William L. Klein

  • Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

    Fernanda G. De Felice;Marcelo N.N. Vieira;Theresa R. Bomfim;Helena Decker

  • Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus

    Hai Wei Wang;Joseph F. Pasternak;Joseph F. Pasternak;Helen Kuo;Helen Ristic

  • Amyloid beta oligomers induce impairment of neuronal insulin receptors

    Wei Qin Zhao;Fernanda G. De Felice;Sara Fernandez;Hui Chen

  • Self-assembly of Aβ1-42 into globular neurotoxins

    Brett A. Chromy;Richard J. Nowak;Mary P. Lambert;Kirsten L. Viola

  • Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

    Kirsten L. Viola;William L. Klein

  • Cholesterol Modulates α-Secretase Cleavage of Amyloid Precursor Protein

    Steven Bodovitz;William L. Klein

  • Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

    Fernanda G. De Felice;Diana Wu;Mary P. Lambert;Sara J. Fernandez

Frequent Co-Authors

Fernanda G. De Felice
Fernanda G. De Felice Queen's University
Sergio T. Ferreira
Sergio T. Ferreira Federal University of Rio de Janeiro
Caleb E. Finch
Caleb E. Finch University of Southern California
Douglas P. Munoz
Douglas P. Munoz Queen's University
Vinayak P. Dravid
Vinayak P. Dravid Northwestern University
Charles G. Glabe
Charles G. Glabe University of California, Irvine
Stephen G. Sligar
Stephen G. Sligar University of Illinois at Urbana-Champaign
Christian Hölscher
Christian Hölscher Henan University
A. Claudio Cuello
A. Claudio Cuello McGill University
Michelle E. Ehrlich
Michelle E. Ehrlich Icahn School of Medicine at Mount Sinai

External Links

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Related Online Degrees & Career Pathways

If you’re interested in neuroscience, there are several related online degrees and career pathways worth exploring. Many students consider degrees in psychology, social work, or counseling, since these fields often overlap with neuroscience both in research and in clinical practice.

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If graduate study interests you, you may be asking, how much does it cost to get a masters in psychology? Costs can vary widely, so it’s critical to compare program tuition, fees, and available financial aid.

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Best Scientists Citing William L. Klein

Nibaldo C. Inestrosa

Nibaldo C. Inestrosa

Pontificia Universidad Católica de Chile

Publications: 86

Fernanda G. De Felice

Fernanda G. De Felice

Queen's University

Publications: 83

George Perry

George Perry

The University of Texas at San Antonio

Publications: 82

Dominic M. Walsh

Dominic M. Walsh

Brigham and Women's Hospital

Publications: 81

David B. Teplow

David B. Teplow

University of California, Los Angeles

Publications: 74

Kaj Blennow

Kaj Blennow

University of Gothenburg

Publications: 73

Sergio T. Ferreira

Sergio T. Ferreira

Federal University of Rio de Janeiro

Publications: 70

Henrik Zetterberg

Henrik Zetterberg

University of Gothenburg

Publications: 70

Dennis J. Selkoe

Dennis J. Selkoe

Brigham and Women's Hospital

Publications: 68

Charles G. Glabe

Charles G. Glabe

University of California, Irvine

Publications: 65

Frank M. LaFerla

Frank M. LaFerla

University of California, Irvine

Publications: 57

Eliezer Masliah

Eliezer Masliah

National Institutes of Health

Publications: 57

Christian Hölscher

Christian Hölscher

Henan University

Publications: 54

Mark A. Smith

Mark A. Smith

Case Western Reserve University

Publications: 49

D. Allan Butterfield

D. Allan Butterfield

University of Kentucky

Publications: 46

Michael J. Rowan

Michael J. Rowan

Trinity College Dublin

Publications: 46

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