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Biology and Biochemistry

D-Index
119
Citations
57495
World Ranking
665
National Ranking
421

Overview

David B. Teplow is affiliated with the University of California, Los Angeles in the United States. Their research primarily spans the field of Medicine, with a focus on several related subfields including Physiology, Molecular Biology, Neurology, Pharmacology, and Complementary and Alternative Medicine.

The main topics covered in David B. Teplow's work include:

  • Alzheimer's disease research and treatments
  • Cholinesterase and Neurodegenerative Diseases
  • Prion Diseases and Protein Misfolding
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Medicinal Plants and Neuroprotection
  • Dementia and Cognitive Impairment Research
  • Parkinson's Disease Mechanisms and Treatments

David B. Teplow has published extensively, with recent papers including:

  • Myricetin prevents high molecular weight Aβ1-42 oligomer-induced neurotoxicity through antioxidant effects in cell membranes and mitochondria, 2021, Free Radical Biology and Medicine
  • Self- and Cross-Seeding on α-Synuclein Fibril Growth Kinetics and Structure Observed by High-Speed Atomic Force Microscopy, 2020, ACS Nano
  • Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Aβ42 Oligomers and Protect Synapses, 2020, Frontiers in Immunology
  • Effects of IL-34 on Macrophage Immunological Profile in Response to Alzheimer's-Related Aβ42 Assemblies, 2020, Frontiers in Immunology
  • The Feasibility of Early Alzheimer's Disease Diagnosis Using a Neural Network Hybrid Platform, 2022, Biosensors

Frequent publication venues for Teplow's work include:

  • Alzheimer s & Dementia
  • Frontiers in Immunology
  • Free Radical Biology and Medicine
  • Biosensors
  • ACS Nano

Notable frequent co-authors through collaborative research efforts are:

  • Kenjiro Ono
  • Mayumi Tsuji
  • Atsushi Kimura
  • Yuji Kiuchi
  • Eric Y. Hayden

David B. Teplow has also contributed to academic literature through book publications, including a work published by Cambridge University Press titled The Philosophy and Practice of Science (2023).

Best Publications

  • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

    Robert Vassar;Brian D. Bennett;Safura Babu-Khan;Steve Kahn

  • Amyloid β-peptide is produced by cultured cells during normal metabolism

    C Haass;M G Schlossmacher;M G Schlossmacher;A Y Hung;C Vigo-Pelfrey

  • A cellular gene encodes scrapie PrP 27-30 protein

    Bruno Oesch;Bruno Oesch;David Westaway;Monika Wälchli;Monika Wälchli;Michael P. McKinley

  • Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.

    Gal Bitan;Marina D. Kirkitadze;Aleksey Lomakin;Sabrina S. Vollers

  • The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.

    Camilla Nilsberth;Anita Westlind-Danielsson;Anita Westlind-Danielsson;Christopher B. Eckman;Margaret M. Condron

  • Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.

    Dominic M. Walsh;Dean M. Hartley;Yoko Kusumoto;Youcef Fezoui

  • Amyloid β-Protein Fibrillogenesis: DETECTION OF A PROTOFIBRILLAR INTERMEDIATE

    Dominic M. Walsh;Aleksey Lomakin;George B. Benedek;Margaret M. Condron

  • Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

    Dean M. Hartley;Dominic M. Walsh;Chianping P. Ye;Thekla Diehl

  • Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

    Summer L. Bernstein;Nicholas F. Dupuis;Noel D. Lazo;Thomas Wyttenbach

  • On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants

    Aleksey Lomakin;Doo Soo Chung;George B. Benedek;Daniel A. Kirschner

  • Structure-neurotoxicity relationships of amyloid β-protein oligomers

    Kenjiro Ono;Margaret M. Condron;David B. Teplow

  • Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis.

    Marina D Kirkitadze;Margaret M Condron;David B Teplow

  • Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin.

    Marion Moos;Roland Tacke;Herta Scherer;David Teplow

  • Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing

    Neil Stahl;Michael A. Baldwin;David B. Teplow;Leroy Hood

  • Amyloid β-Protein Assembly and Alzheimer Disease

    Robin Roychaudhuri;Mingfeng Yang;Minako M. Hoshi;David B. Teplow

  • Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies.

    Marina D. Kirkitadze;Gal Bitan;Gal Bitan;David B. Teplow;David B. Teplow

  • Kinetic theory of fibrillogenesis of amyloid β-protein

    Aleksey Lomakin;David B. Teplow;Daniel A. Kirschner;George B. Benedek

  • beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms

    C Haass;A Y Hung;M G Schlossmacher;D B Teplow

  • Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

    Magdalena Sastre;Harald Steiner;Klaus Fuchs;Anja Capell

  • Truncated forms of the human prion protein in normal brain and in prion diseases.

    Shu G. Chen;David B. Teplow;Piero Parchi;Jan K. Teller

Frequent Co-Authors

Dennis J. Selkoe
Dennis J. Selkoe Brigham and Women's Hospital
Gal Bitan
Gal Bitan University of California, Los Angeles
Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Michael T. Bowers
Michael T. Bowers University of California, Santa Barbara
Giulio Maria Pasinetti
Giulio Maria Pasinetti Icahn School of Medicine at Mount Sinai
Lap Ho
Lap Ho Icahn School of Medicine at Mount Sinai
Martin Citron
Martin Citron Amgen (United States)
Masahito Yamada
Masahito Yamada Kanazawa University
Dominic M. Walsh
Dominic M. Walsh Brigham and Women's Hospital

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