Dominic M. Walsh

Overview

Best Publications

• Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

  Dominic M. Walsh;Igor Klyubin;Julia V. Fadeeva;William K. Cullen

  5554
  Citations

• Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.

  Ganesh M Shankar;Shaomin Li;Tapan H Mehta;Amaya Garcia-Munoz

  4513
  Citations

• A beta oligomers - a decade of discovery.

  Dominic M. Walsh;Dennis J. Selkoe

  2832
  Citations

• Natural oligomers of the amyloid-|[beta]| protein specifically disrupt cognitive function

  James P Cleary;Dominic M Walsh;Dominic M Walsh;Jacki J Hofmeister;Ganesh M Shankar

  2190
  Citations

• Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

  Ganesh M. Shankar;Brenda L. Bloodgood;Matthew Townsend;Dominic M. Walsh

  2047
  Citations

• Deciphering the molecular basis of memory failure in Alzheimer's disease.

  Dominic M. Walsh;Dominic M. Walsh;Dennis J. Selkoe

  1563
  Citations

• Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.

  Dominic M. Walsh;Dean M. Hartley;Yoko Kusumoto;Youcef Fezoui

  1421
  Citations

• Amyloid β-Protein Fibrillogenesis: DETECTION OF A PROTOFIBRILLAR INTERMEDIATE

  Dominic M. Walsh;Aleksey Lomakin;George B. Benedek;Margaret M. Condron

  1359
  Citations

• Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

  Dean M. Hartley;Dominic M. Walsh;Chianping P. Ye;Thekla Diehl

  1225
  Citations

• Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.

  Melanie Meyer-Luehmann;Janaky Coomaraswamy;Tristan Bolmont;Tristan Bolmont;Stephan Kaeser

  1124
  Citations

• Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

  Shaomin Li;Soyon Hong;Nina E. Shepardson;Dominic M. Walsh

  1110
  Citations

• Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

  Wei Qiao Qiu;Dominic M. Walsh;Zhen Ye;Konstantinos Vekrellis

  1076
  Citations

• Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

  Ming Jin;Nina Shepardson;Ting Yang;Gang Chen

  1045
  Citations

• Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

  Malcolm A Leissring;Wesley Farris;Alice Y Chang;Dominic M Walsh

  905
  Citations

• Effects of secreted oligomers of amyloid β-protein on hippocampal synaptic plasticity: a potent role for trimers

  Matthew Townsend;Ganesh M. Shankar;Tapan Mehta;Dominic M. Walsh

  802
  Citations

• Amyloid-β oligomers: their production, toxicity and therapeutic inhibition

  D. M. Walsh;I. Klyubin;J. V. Fadeeva;M. J. Rowan

  768
  Citations

• Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.

  G. Brent Irvine;Omar M. El-Agnaf;Ganesh M. Shankar;Dominic M. Walsh;Dominic M. Walsh

  686
  Citations

• Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

  Qinwen Wang;Dominic M. Walsh;Michael J. Rowan;Dennis J. Selkoe

  677
  Citations

• Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

  Igor Klyubin;Dominic M Walsh;Dominic M Walsh;Cynthia A Lemere;William K Cullen

  676
  Citations

• The Formation of Highly Soluble Oligomers of α-Synuclein Is Regulated by Fatty Acids and Enhanced in Parkinson's Disease

  Ronit Sharon;Ifat Bar-Joseph;Matthew P Frosch;Dominic M Walsh

  663
  Citations