Dominic M. Walsh mainly investigates Biochemistry, Amyloid, Long-term potentiation, Amyloid beta and Alzheimer's disease. His Biochemistry research incorporates elements of Amyloid precursor protein secretase and Oligomer. His Amyloid study combines topics from a wide range of disciplines, such as Cell culture, Fibril, Fibrillogenesis, Extracellular and Hippocampal formation.
His work carried out in the field of Long-term potentiation brings together such families of science as Synaptic plasticity, Amyloid β, Cell biology, Hippocampus and In vivo. His Amyloid beta study incorporates themes from Biophysics, Protease and P3 peptide. The Alzheimer's disease study combines topics in areas such as Genetically modified mouse and Neurodegeneration.
His primary scientific interests are in Amyloid, Biochemistry, Long-term potentiation, Neuroscience and Amyloid precursor protein. Dominic M. Walsh combines subjects such as Amyloid beta, Hippocampal formation, Cell biology, Alzheimer's disease and Monomer with his study of Amyloid. His biological study spans a wide range of topics, including P3 peptide, Antibody and Amyloid precursor protein secretase.
The study incorporates disciplines such as Biochemistry of Alzheimer's disease and Senile plaques in addition to P3 peptide. His Long-term potentiation research includes themes of Synaptic plasticity, Hippocampus, Pharmacology and In vivo. His studies in Neuroscience integrate themes in fields like Glutamate receptor, NMDA receptor and Disease, Neurodegeneration.
Dominic M. Walsh focuses on Amyloid, Long-term potentiation, Cell biology, Disease and Biochemistry. The various areas that Dominic M. Walsh examines in his Amyloid study include Covalent bond, Neurite, Amyloid precursor protein, Antibody and Monomer. His work carried out in the field of Long-term potentiation brings together such families of science as Synaptic plasticity, Glutamate receptor, NMDA receptor and Hippocampal formation, Neuroscience.
Dominic M. Walsh has included themes like Hippocampus, Inhibitory postsynaptic potential and Amyloid beta in his Synaptic plasticity study. His study in Disease is interdisciplinary in nature, drawing from both Biomarker and Neurology. Dominic M. Walsh interconnects Video microscopy, Amyloid β, Toxicity and In vivo in the investigation of issues within Biochemistry.
Dominic M. Walsh spends much of his time researching Long-term potentiation, Disease, Neuroscience, Neurodegeneration and Cell biology. Long-term potentiation is a subfield of Biochemistry that he investigates. His Biochemistry study incorporates themes from Inflammation, Microglia and In vivo.
His Disease research incorporates elements of Hyperactivation, Pathological and Cellular mechanism. His Neuroscience research is multidisciplinary, incorporating perspectives in Disease progression and Symptom onset. His Neurodegeneration research incorporates themes from Blocking antibody, Senile plaques, Biophysics, PRNP and Dementia with Lewy bodies.
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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
Dominic M. Walsh;Igor Klyubin;Julia V. Fadeeva;William K. Cullen.
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
Ganesh M Shankar;Shaomin Li;Tapan H Mehta;Amaya Garcia-Munoz.
Nature Medicine (2008)
A beta oligomers - a decade of discovery.
Dominic M. Walsh;Dennis J. Selkoe.
Journal of Neurochemistry (2007)
Natural oligomers of the amyloid-|[beta]| protein specifically disrupt cognitive function
James P Cleary;Dominic M Walsh;Dominic M Walsh;Jacki J Hofmeister;Ganesh M Shankar.
Nature Neuroscience (2005)
Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway
Ganesh M. Shankar;Brenda L. Bloodgood;Matthew Townsend;Dominic M. Walsh.
The Journal of Neuroscience (2007)
Deciphering the molecular basis of memory failure in Alzheimer's disease.
Dominic M. Walsh;Dominic M. Walsh;Dennis J. Selkoe.
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.
Dominic M. Walsh;Dean M. Hartley;Yoko Kusumoto;Youcef Fezoui.
Journal of Biological Chemistry (1999)
Amyloid β-Protein Fibrillogenesis: DETECTION OF A PROTOFIBRILLAR INTERMEDIATE
Dominic M. Walsh;Aleksey Lomakin;George B. Benedek;Margaret M. Condron.
Journal of Biological Chemistry (1997)
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.
Dean M. Hartley;Dominic M. Walsh;Chianping P. Ye;Thekla Diehl.
The Journal of Neuroscience (1999)
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
Wei Qiao Qiu;Dominic M. Walsh;Zhen Ye;Konstantinos Vekrellis.
Journal of Biological Chemistry (1998)
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