D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 88 Citations 48,485 250 World Ranking 1682 National Ranking 957

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Biochemistry
  • Amino acid

Dominic M. Walsh mainly investigates Biochemistry, Amyloid, Long-term potentiation, Amyloid beta and Alzheimer's disease. His Biochemistry research incorporates elements of Amyloid precursor protein secretase and Oligomer. His Amyloid study combines topics from a wide range of disciplines, such as Cell culture, Fibril, Fibrillogenesis, Extracellular and Hippocampal formation.

His work carried out in the field of Long-term potentiation brings together such families of science as Synaptic plasticity, Amyloid β, Cell biology, Hippocampus and In vivo. His Amyloid beta study incorporates themes from Biophysics, Protease and P3 peptide. The Alzheimer's disease study combines topics in areas such as Genetically modified mouse and Neurodegeneration.

His most cited work include:

  • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. (3673 citations)
  • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. (2747 citations)
  • A beta oligomers - a decade of discovery. (1620 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Amyloid, Biochemistry, Long-term potentiation, Neuroscience and Amyloid precursor protein. Dominic M. Walsh combines subjects such as Amyloid beta, Hippocampal formation, Cell biology, Alzheimer's disease and Monomer with his study of Amyloid. His biological study spans a wide range of topics, including P3 peptide, Antibody and Amyloid precursor protein secretase.

The study incorporates disciplines such as Biochemistry of Alzheimer's disease and Senile plaques in addition to P3 peptide. His Long-term potentiation research includes themes of Synaptic plasticity, Hippocampus, Pharmacology and In vivo. His studies in Neuroscience integrate themes in fields like Glutamate receptor, NMDA receptor and Disease, Neurodegeneration.

He most often published in these fields:

  • Amyloid (30.54%)
  • Biochemistry (29.53%)
  • Long-term potentiation (17.79%)

What were the highlights of his more recent work (between 2015-2021)?

  • Amyloid (30.54%)
  • Long-term potentiation (17.79%)
  • Cell biology (13.09%)

In recent papers he was focusing on the following fields of study:

Dominic M. Walsh focuses on Amyloid, Long-term potentiation, Cell biology, Disease and Biochemistry. The various areas that Dominic M. Walsh examines in his Amyloid study include Covalent bond, Neurite, Amyloid precursor protein, Antibody and Monomer. His work carried out in the field of Long-term potentiation brings together such families of science as Synaptic plasticity, Glutamate receptor, NMDA receptor and Hippocampal formation, Neuroscience.

Dominic M. Walsh has included themes like Hippocampus, Inhibitory postsynaptic potential and Amyloid beta in his Synaptic plasticity study. His study in Disease is interdisciplinary in nature, drawing from both Biomarker and Neurology. Dominic M. Walsh interconnects Video microscopy, Amyloid β, Toxicity and In vivo in the investigation of issues within Biochemistry.

Between 2015 and 2021, his most popular works were:

  • A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration (176 citations)
  • Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. (148 citations)
  • A vicious cycle of β amyloid-dependent neuronal hyperactivation. (125 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Biochemistry
  • Organic chemistry

Dominic M. Walsh spends much of his time researching Long-term potentiation, Disease, Neuroscience, Neurodegeneration and Cell biology. Long-term potentiation is a subfield of Biochemistry that he investigates. His Biochemistry study incorporates themes from Inflammation, Microglia and In vivo.

His Disease research incorporates elements of Hyperactivation, Pathological and Cellular mechanism. His Neuroscience research is multidisciplinary, incorporating perspectives in Disease progression and Symptom onset. His Neurodegeneration research incorporates themes from Blocking antibody, Senile plaques, Biophysics, PRNP and Dementia with Lewy bodies.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

Dominic M. Walsh;Igor Klyubin;Julia V. Fadeeva;William K. Cullen.
Nature (2002)

5164 Citations

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.

Ganesh M Shankar;Shaomin Li;Tapan H Mehta;Amaya Garcia-Munoz.
Nature Medicine (2008)

3976 Citations

A beta oligomers - a decade of discovery.

Dominic M. Walsh;Dennis J. Selkoe.
Journal of Neurochemistry (2007)

2734 Citations

Natural oligomers of the amyloid-|[beta]| protein specifically disrupt cognitive function

James P Cleary;Dominic M Walsh;Dominic M Walsh;Jacki J Hofmeister;Ganesh M Shankar.
Nature Neuroscience (2005)

2099 Citations

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Ganesh M. Shankar;Brenda L. Bloodgood;Matthew Townsend;Dominic M. Walsh.
The Journal of Neuroscience (2007)

1844 Citations

Deciphering the molecular basis of memory failure in Alzheimer's disease.

Dominic M. Walsh;Dominic M. Walsh;Dennis J. Selkoe.
Neuron (2004)

1492 Citations

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.

Dominic M. Walsh;Dean M. Hartley;Yoko Kusumoto;Youcef Fezoui.
Journal of Biological Chemistry (1999)

1383 Citations

Amyloid β-Protein Fibrillogenesis: DETECTION OF A PROTOFIBRILLAR INTERMEDIATE

Dominic M. Walsh;Aleksey Lomakin;George B. Benedek;Margaret M. Condron.
Journal of Biological Chemistry (1997)

1321 Citations

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

Dean M. Hartley;Dominic M. Walsh;Chianping P. Ye;Thekla Diehl.
The Journal of Neuroscience (1999)

1187 Citations

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

Wei Qiao Qiu;Dominic M. Walsh;Zhen Ye;Konstantinos Vekrellis.
Journal of Biological Chemistry (1998)

1042 Citations

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