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Molecular Biology

D-Index
51
Citations
14133
World Ranking
2479
National Ranking
43

Overview

Massimo Lopes is affiliated with the University of Zurich in Switzerland. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a substantial body of work in medicine. Their studies delve into various subfields such as molecular biology, oncology, hematology, genetics, and cell biology.

The main themes in Lopes' research address DNA repair mechanisms, PARP inhibition in cancer therapy, CRISPR and genetic engineering, genomics and chromatin dynamics, cancer-related molecular pathways, RNA research and splicing, as well as epigenetics and DNA methylation.

Some of their recent publications include the following:

  • The plasticity of DNA replication forks in response to clinically relevant genotoxic stress, 2020, Nature Reviews Molecular Cell Biology
  • HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis, 2020, Molecular Cell
  • Sequential role of RAD51 paralog complexes in replication fork remodeling and restart, 2020, Nature Communications
  • PrimPol-mediated repriming facilitates replication traverse of DNA interstrand crosslinks, 2021, The EMBO Journal
  • Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids, 2023, Nature Structural & Molecular Biology

Lopes collaborates frequently with a group of researchers including:

  • Andrea Sanchi
  • Jana Krietsch
  • Daniel González-Acosta
  • Henriette Stoy
  • Jonas Schmid

Their work has been published recurrently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Molecular Cell, The EMBO Journal, and Nucleic Acids Research.

Best Publications

  • Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

    José M. Sogo;Massimo Lopes;Marco Foiani

  • The DNA replication checkpoint response stabilizes stalled replication forks

    Massimo Lopes;Cecilia Cotta-Ramusino;Achille Pellicioli;Giordano Liberi

  • Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions.

    Massimo Lopes;Marco Foiani;José M. Sogo

  • Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

    Ralph Zellweger;Damian Dalcher;Karun Mutreja;Matteo Berti

  • Replication fork reversal in eukaryotes: from dead end to dynamic response.

    Kai J. Neelsen;Massimo Lopes

  • Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

    Yoshitami Hashimoto;Arnab Ray Chaudhuri;Massimo Lopes;Vincenzo Costanzo

  • Topoisomerase I poisoning results in PARP-mediated replication fork reversal

    Arnab Ray Chaudhuri;Yoshitami Hashimoto;Raquel Herrador;Kai J Neelsen

  • Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase

    Achille Pellicioli;Chiara Lucca;Giordano Liberi;Federica Marini;Federica Marini

  • Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

    Matteo Berti;Arnab Ray Chaudhuri;Saravanabhavan Thangavel;Shivasankari Gomathinayagam

  • Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase.

    Giordano Liberi;Giulio Maffioletti;Chiara Lucca;Irene Chiolo

  • Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.

    Isabella M. Toller;Kai J. Neelsen;Martin Steger;Mara L. Hartung

  • DNA2 drives processing and restart of reversed replication forks in human cells

    Saravanabhavan Thangavel;Matteo Berti;Maryna Levikova;Cosimo Pinto

  • Replication Fork Reversal Triggers Fork Degradation in BRCA2-defective Cells

    Sofija Mijic;Ralph Zellweger;Nagaraja Chappidi;Matteo Berti

  • Exo1 Processes Stalled Replication Forks and Counteracts Fork Reversal in Checkpoint-Defective Cells

    Cecilia Cotta-Ramusino;Daniele Fachinetti;Chiara Lucca;Ylli Doksani

  • Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

    Ewa Gogola;Alexandra A. Duarte;Julian R. de Ruiter;Wouter W. Wiegant

  • Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

    Panagiotis Galanos;Konstantinos Vougas;David Walter;Alexander Polyzos

  • The plasticity of DNA replication forks in response to clinically relevant genotoxic stress

    Matteo Berti;David Cortez;Massimo Lopes

  • Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness

    Hitoshi Takizawa;Hitoshi Takizawa;Kristin Fritsch;Larisa V. Kovtonyuk;Yasuyuki Saito

  • Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

    Kai J. Neelsen;Isabella M.Y. Zanini;Raquel Herrador;Massimo Lopes

  • Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA

    Nina Mojas;Massimo Lopes;Josef Jiricny

Frequent Co-Authors

Marco Foiani
Marco Foiani University of Milan
Paolo Plevani
Paolo Plevani University of Milan
Jiri Bartek
Jiri Bartek Karolinska Institute
Alessandro Vindigni
Alessandro Vindigni Washington University in St. Louis
Josef Jiricny
Josef Jiricny University of Zurich
David Cortez
David Cortez Vanderbilt University
Vassilis G. Gorgoulis
Vassilis G. Gorgoulis National and Kapodistrian University of Athens
Sven Rottenberg
Sven Rottenberg University of Bern
David Shore
David Shore University of Geneva

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