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Molecular Biology

D-Index
72
Citations
27714
World Ranking
1303
National Ranking
669

Overview

David Cortez is affiliated with Vanderbilt University in the United States and has a significant body of research within the field of Biochemistry, Genetics, and Molecular Biology. Their work focuses heavily on Molecular Biology, with notable contributions in Oncology, Plant Science, Infectious Diseases, and Cancer Research.

The scientist's key research topics encompass DNA Repair Mechanisms, CRISPR and Genetic Engineering, Genomics and Chromatin Dynamics, DNA and Nucleic Acid Chemistry, Cancer therapeutics and mechanisms, Epigenetics and DNA Methylation, and PARP inhibition in cancer therapy.

Several recent papers illustrate the scope of their research interests and contributions:

  • The plasticity of DNA replication forks in response to clinically relevant genotoxic stress, 2020, Nature Reviews Molecular Cell Biology
  • New insights into abasic site repair and tolerance, 2020, DNA Repair
  • Two replication fork remodeling pathways generate nuclease substrates for distinct fork protection factors, 2020, Science Advances
  • RAD51 bypasses the CMG helicase to promote replication fork reversal, 2023, Science
  • HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation, 2020, Cell Reports

Frequent co-authors of David Cortez include:

  • Kavi P.M. Mehta
  • Madison B. Adolph
  • Brandt F. Eichman
  • Runxiang Zhao
  • James M. Dewar

Their publications often appear in a range of specialized journals and venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Molecular Cell
  • Journal of Biological Chemistry
  • Science Advances

Best Publications

  • Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint

    Qinghua Liu;Saritha Guntuku;Xian Shu Cui;Shuhei Matsuoka

  • ATR: an essential regulator of genome integrity

    Karlene A. Cimprich;David Cortez

  • BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

    Yi Wang;David Cortez;Parvin Yazdi;Norma Neff

  • Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

    David Cortez;Yi Wang;Jun Qin;Stephen J. Elledge;Stephen J. Elledge

  • ATR and ATRIP: Partners in Checkpoint Signaling

    David Cortez;Saritha Guntuku;Jun Qin;Stephen J. Elledge;Stephen J. Elledge

  • Replication fork stability confers chemoresistance in BRCA-deficient cells

    Arnab Ray Chaudhuri;Elsa Callen;Xia Ding;Ewa Gogola

  • The essential kinase ATR: ensuring faithful duplication of a challenging genome

    Joshua C. Saldivar;David Cortez;Karlene A. Cimprich

  • Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

    Randal S. Tibbetts;David Cortez;Kathryn M. Brumbaugh;Ralph Scully

  • Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.

    Lee Zou;David Cortez;Stephen J. Elledge

  • A requirement for NF-κB activation in Bcr–Abl-mediated transformation

    Julie Y. Reuther;Gary W. Reuther;Gary W. Reuther;David Cortez;David Cortez;Ann Marie Pendergast

  • Analysis of protein dynamics at active, stalled, and collapsed replication forks

    Bianca M. Sirbu;Frank B. Couch;Jordan T. Feigerle;Srividya Bhaskara

  • Deletion of Histone Deacetylase 3 reveals critical roles in S-phase progression and DNA damage control

    Srividya Bhaskara;Brenda J. Chyla;Joseph M. Amann;Sarah K. Knutson

  • TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

    Daniel A. Mordes;Gloria G. Glick;Runxiang Zhao;David Cortez

  • ATR phosphorylates SMARCAL1 to prevent replication fork collapse

    Frank B. Couch;Carol E. Bansbach;Robert Driscoll;Jessica W. Luzwick

  • Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

    David Cortez;Gloria Glick;Stephen J. Elledge

  • Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11

    Jeremy S. Myers;David Cortez

  • Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis.

    David Cortez;Lisa Kadlec;Andann Marie Pendergast

  • ATR signalling: more than meeting at the fork

    Edward A. Nam;David Cortez

  • The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes

    Qinghua Liu;Mamie Z. Li;Deborah Leibham;David Cortez

  • Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to

    Yi Wang;David Cortez

Frequent Co-Authors

Stephen J. Elledge
Stephen J. Elledge Harvard University
Walter J. Chazin
Walter J. Chazin Vanderbilt University
Karlene A. Cimprich
Karlene A. Cimprich Stanford University
Ann Marie Pendergast
Ann Marie Pendergast Duke University
Sven Rottenberg
Sven Rottenberg University of Bern
Jun Qin
Jun Qin Baylor College of Medicine
Scott W. Hiebert
Scott W. Hiebert Vanderbilt University
Cornelius F. Boerkoel
Cornelius F. Boerkoel University of British Columbia
Jennifer A. Pietenpol
Jennifer A. Pietenpol Vanderbilt University Medical Center
Massimo Lopes
Massimo Lopes University of Zurich

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