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Molecular Biology

D-Index
76
Citations
27331
World Ranking
1136
National Ranking
590

Overview

Lee Zou is affiliated with Duke University in the United States and specializes in research within Biochemistry, Genetics, and Molecular Biology. Their work spans multiple subfields, including Molecular Biology, Oncology, Cancer Research, Genetics, and Cell Biology.

The major research topics that Lee Zou focuses on include:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • PARP inhibition in cancer therapy
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Genomics and Chromatin Dynamics
  • Cancer-related Molecular Pathways

Lee Zou has published extensively, with frequent appearances in several key scientific journals. The most common publication venues include:

  • Nature Communications (10 publications)
  • Molecular Cell (9 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)
  • Genes & Development (5 publications)
  • Science Advances (5 publications)

Some of Lee Zou's recent papers are:

  • Hallmarks of DNA replication stress, 2022, Molecular Cell
  • Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids, 2022, Nature Reviews Molecular Cell Biology
  • FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation, 2022, Proceedings of the National Academy of Sciences
  • Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells, 2021, Molecular Cell
  • Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks, 2020, Cell & Bioscience

Frequent co-authors collaborating with Lee Zou include:

  • Antoine Simoneau
  • Li Lan
  • Michael S. Lawrence
  • Jian Ouyang
  • Sneha Saxena

Through their work, Lee Zou contributes to a broad spectrum of research areas that intersect molecular biology and cancer-focused studies, often emphasizing mechanisms of DNA repair, RNA processes, and genetic engineering technologies.

Best Publications

  • Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

    Lee Zou;Stephen J. Elledge

  • A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

    Sreenath V. Sharma;Diana Y. Lee;Bihua Li;Margaret P. Quinlan

  • DNA damage sensing by the ATM and ATR kinases.

    Alexandre Maréchal;Lee Zou

  • RNA m6A methylation regulates the ultraviolet-induced DNA damage response.

    Yang Xiang;Benoit Laurent;Benoit Laurent;Chih-Hung Hsu;Chih-Hung Hsu;Sigrid Nachtergaele

  • Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.

    Lee Zou;David Cortez;Stephen J. Elledge

  • Replication protein A-mediated recruitment and activation of Rad17 complexes

    Lee Zou;Dou Liu;Stephen J. Elledge

  • Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

    Rachel Litman Flynn;Rachel Litman Flynn;Kelli E. Cox;Maya Jeitany;Hiroaki Wakimoto

  • Assembly of a Complex Containing Cdc45p, Replication Protein A, and Mcm2p at Replication Origins Controlled by S-Phase Cyclin-Dependent Kinases and Cdc7p-Dbf4p Kinase

    Lee Zou;Bruce Stillman

  • Checking on the fork: the DNA-replication stress-response pathway.

    Alexander J Osborn;Stephen J Elledge;Lee Zou

  • RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response.

    Alexandre Maréchal;Lee Zou

  • Formation of a Preinitiation Complex by S-phase Cyclin CDK-Dependent Loading of Cdc45p onto Chromatin

    Lee Zou;Bruce Stillman

  • Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

    Bunsyo Shiotani;Lee Zou

  • TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

    Rachel Litman Flynn;Richard C. Centore;Roderick J. O’Sullivan;Rekha Rai

  • Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain.

    Gaylor Boulay;Gabriel J. Sandoval;Nicolo Riggi;Sowmya Iyer

  • MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

    Delphine Lemaçon;Jessica Jackson;Annabel Quinet;Joshua R. Brickner

  • Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

    Kyosuke Nakamura;Akihiro Kato;Junya Kobayashi;Hiromi Yanagihara

  • ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.

    Stephanie A. Yazinski;Valentine Comaills;Rémi Buisson;Marie Michelle Genois

  • ATR: a master conductor of cellular responses to DNA replication stress

    Rachel Litman Flynn;Lee Zou

  • Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase.

    Rémi Buisson;Jessica L. Boisvert;Cyril H. Benes;Lee Zou

  • ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation

    Shizhou Liu;Bunsyo Shiotani;Mayurika Lahiri;Alexandre Maréchal

Frequent Co-Authors

Daniel A. Haber
Daniel A. Haber Harvard University
Michael S. Lawrence
Michael S. Lawrence Harvard University
Li Lan
Li Lan Duke University
Cyril H. Benes
Cyril H. Benes Harvard University
Stephen J. Elledge
Stephen J. Elledge Harvard University
Shyamala Maheswaran
Shyamala Maheswaran Harvard University
Sridhar Ramaswamy
Sridhar Ramaswamy Harvard University
Wilhelm Haas
Wilhelm Haas Harvard University
Lei Li
Lei Li The University of Texas MD Anderson Cancer Center
Kunle Odunsi
Kunle Odunsi Roswell Park Cancer Institute

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