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Maria Pia Longhese

Maria Pia Longhese

D-Index & Metrics

Molecular Biology

D-Index
52
Citations
8614
World Ranking
2447
National Ranking
58

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Maria Pia Longhese is affiliated with the University of Milano-Bicocca in Italy and conducts research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work focuses on subfields such as Molecular Biology, Oncology, Cancer Research, Cell Biology, and Plant Science.

The scientist's research topics include:

  • DNA Repair Mechanisms
  • PARP inhibition in cancer therapy
  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • Carcinogens and Genotoxicity Assessment
  • Microtubule and mitosis dynamics
  • Photosynthetic Processes and Mechanisms

Recent publications by Maria Pia Longhese cover a range of subjects in molecular biology and DNA damage response. Notable papers include:

  • "Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability," 2021, Frontiers in Cell and Developmental Biology
  • "Functional and structural insights into the MRX/MRN complex, a key player in recognition and repair of DNA double-strand breaks," 2020, Computational and Structural Biotechnology Journal
  • "The DNA damage checkpoint: A tale from budding yeast," 2022, Frontiers in Genetics
  • "Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners," 2021, Cell Reports
  • "The 9-1-1 Complex Controls Mre11 Nuclease and Checkpoint Activation during Short-Range Resection of DNA Double-Strand Breaks," 2020, Cell Reports

Maria Pia Longhese frequently collaborates with the following researchers:

  • Erika Casari
  • Marco Gnugnoli
  • Carlo Rinaldi
  • Paolo Pizzul
  • Renata Tisi

Publications have appeared in multiple venues, with a concentration in:

  • Cell Reports
  • Nucleic Acids Research
  • Nature Communications
  • Biochemical Society Transactions
  • PLoS Genetics

Maria Pia Longhese has been recognized as a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

    Marzia Fumagalli;Francesca Rossiello;Michela Clerici;Sara Barozzi

  • A Central Role for DNA Replication Forks in Checkpoint Activation and Response

    José Antonio Tercero;Maria Pia Longhese;John F.X Diffley

  • The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast

    Vera Paciotti;Michela Clerici;Giovanna Lucchini;Maria Pia Longhese

  • The Saccharomyces cerevisiae Sae2 Protein Promotes Resection and Bridging of Double Strand Break Ends

    Michela Clerici;Davide Mantiero;Giovanna Lucchini;Maria Pia Longhese

  • DNA damage response at functional and dysfunctional telomeres.

    Maria Pia Longhese

  • DNA damage checkpoint in budding yeast.

    Maria Pia Longhese;Marco Foiani;Marco Muzi‐Falconi;Giovanna Lucchini

  • The Yku70–Yku80 complex contributes to regulate double‐strand break processing and checkpoint activation during the cell cycle

    Michela Clerici;Davide Mantiero;Ilaria Guerini;Giovanna Lucchini

  • RPA regulates telomerase action by providing Est1p access to chromosome ends.

    Vera Schramke;Pierre Luciano;Vanessa Brevet;Sylvine Guillot

  • The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling.

    Michela Clerici;Davide Mantiero;Giovanna Lucchini;Maria Pia Longhese

  • Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p

    Vera Paciotti;Giovanna Lucchini;Paolo Plevani;Maria Pia Longhese

  • Replication factor A is required in vivo for DNA replication, repair, and recombination.

    M P Longhese;P Plevani;G Lucchini

  • The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast

    Maria Pia Longhese;Vera Paciotti;Roberta Fraschini;Raffaella Zaccarini

  • Multiple Pathways Regulate 3′ Overhang Generation at S. cerevisiae Telomeres

    Diego Bonetti;Marina Martina;Michela Clerici;Giovanna Lucchini

  • Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks.

    Davide Mantiero;Michela Clerici;Giovanna Lucchini;Maria Pia Longhese

  • The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.

    Enrico Baroni;Valeria Viscardi;Hugo Cartagena-Lirola;Giovanna Lucchini

  • Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

    Francesca Rossiello;Utz Herbig;Maria Pia Longhese;Marzia Fumagalli

  • Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint.

    Michele Giannattasio;Federico Lazzaro;Maria Pia Longhese;Paolo Plevani

  • Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway.

    Vera Paciotti;Michela Clerici;Maddalena Scotti;Giovanna Lucchini

  • Mechanisms and regulation of DNA end resection

    Maria Pia Longhese;Diego Bonetti;Nicola Manfrini;Michela Clerici

  • Erratum: Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation (Nature Cell Biology (2012) 14 (355-365))

    Marzia Fumagalli;Francesca Rossiello;Michela Clerici;Sara Barozzi

Frequent Co-Authors

Giovanna Lucchini
Giovanna Lucchini University of Milan
Paolo Plevani
Paolo Plevani University of Milan
Marco Foiani
Marco Foiani University of Milan
Fabrizio d'Adda di Fagagna
Fabrizio d'Adda di Fagagna University of Cambridge
Eric Gilson
Eric Gilson Université Côte d'Azur
Patrick Sung
Patrick Sung The University of Texas Health Science Center at San Antonio
Vincent Géli
Vincent Géli Centre de Recherche en Cancérologie de Marseille
Saverio Minucci
Saverio Minucci European Institute of Oncology
John F. X. Diffley
John F. X. Diffley The Francis Crick Institute
Michael Lisby
Michael Lisby University of Copenhagen

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