2020 - Member of the National Academy of Sciences
2019 - Canada Gairdner International Award
2009 - Member of Academia Europaea
2007 - Fellow of the American Association for the Advancement of Science (AAAS)
2005 - Fellow of the Royal Society, United Kingdom
2003 - Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center
Member of the European Molecular Biology Organization (EMBO)
Fellow of The Academy of Medical Sciences, United Kingdom
His primary scientific interests are in Origin recognition complex, Control of chromosome duplication, Cell biology, Eukaryotic DNA replication and Pre-replication complex. His Origin recognition complex study introduces a deeper knowledge of DNA replication. Control of chromosome duplication is a primary field of his research addressed under Biochemistry.
His Cell biology research incorporates themes from Cell cycle and Cyclin-dependent kinase. His study in Eukaryotic DNA replication is interdisciplinary in nature, drawing from both G2-M DNA damage checkpoint and Molecular biology. His Pre-replication complex research focuses on subjects like Minichromosome maintenance, which are linked to DNA replication initiation and DNA replication origin.
His primary areas of investigation include Cell biology, Origin recognition complex, Control of chromosome duplication, DNA replication and Eukaryotic DNA replication. The study incorporates disciplines such as DNA damage, Cyclin-dependent kinase, Biochemical switches in the cell cycle, Cell cycle and Replisome in addition to Cell biology. His Origin recognition complex study combines topics from a wide range of disciplines, such as DNA replication factor CDT1, Pre-replication complex, DNA replication origin, ORC6 and Licensing factor.
His Control of chromosome duplication study deals with the bigger picture of Genetics. His DNA replication research is multidisciplinary, relying on both Molecular biology, Saccharomyces cerevisiae and Helicase. His research investigates the link between Eukaryotic DNA replication and topics such as G2-M DNA damage checkpoint that cross with problems in DNA repair and DNA replication checkpoint.
Cell biology, DNA, Helicase, DNA replication and Replisome are his primary areas of study. His Cell biology study combines topics in areas such as Genetics, DNA damage and Eukaryotic DNA replication. John F. X. Diffley studied Helicase and Origin recognition complex that intersect with DNA replication factor CDT1.
His study of Replication Initiation is a part of DNA replication. In his research on the topic of Replisome, Polymerase and Molecular biology is strongly related with DNA polymerase. In his work, Chromatin, Pre-replication complex and Replication factor C is strongly intertwined with DNA replication origin, which is a subfield of Minichromosome maintenance.
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A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
Corrado Santocanale;John F. X. Diffley.
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
José Antonio Tercero;John F. X. Diffley.
Uninterrupted MCM2-7 Function Required for DNA Replication Fork Progression
Karim Labib;José Antonio Tercero;John F. X. Diffley.
Two steps in the assembly of complexes at yeast replication origins in vivo
John F.X. Diffley;Julie H. Cocker;Simon J. Dowell;Adele Rowley.
Concerted Loading of Mcm2-7 Double Hexamers Around DNA during DNA Replication Origin Licensing
Dirk Remus;Fabienne Beuron;Gökhan Tolun;Jack D. Griffith.
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast
Shane Donovan;Janet Harwood;Lucy S. Drury;John F. X. Diffley.
Proceedings of the National Academy of Sciences of the United States of America (1997)
Mrc1 transduces signals of DNA replication stress to activate Rad53.
Annette A. Alcasabas;Alexander J. Osborn;Jeff Bachant;Jeff Bachant;Fenghua Hu.
Nature Cell Biology (2001)
Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast
Philip Zegerman;John F. X. Diffley.
Regulation of Early Events in Chromosome Replication
John F.X. Diffley.
Current Biology (2004)
S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state.
Christian Dahmann;John F.X. Diffley;Kim A. Nasmyth.
Current Biology (1995)
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