What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Origin recognition complex, Control of chromosome duplication, Cell biology, Eukaryotic DNA replication and Pre-replication complex.
His Origin recognition complex study introduces a deeper knowledge of DNA replication.
Control of chromosome duplication is a primary field of his research addressed under Biochemistry.
His Cell biology research incorporates themes from Cell cycle and Cyclin-dependent kinase.
His study in Eukaryotic DNA replication is interdisciplinary in nature, drawing from both G2-M DNA damage checkpoint and Molecular biology.
His Pre-replication complex research focuses on subjects like Minichromosome maintenance, which are linked to DNA replication initiation and DNA replication origin.
His most cited work include:
- A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication (586 citations)
- Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint (579 citations)
- Uninterrupted MCM2-7 Function Required for DNA Replication Fork Progression (548 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Cell biology, Origin recognition complex, Control of chromosome duplication, DNA replication and Eukaryotic DNA replication.
The study incorporates disciplines such as DNA damage, Cyclin-dependent kinase, Biochemical switches in the cell cycle, Cell cycle and Replisome in addition to Cell biology.
His Origin recognition complex study combines topics from a wide range of disciplines, such as DNA replication factor CDT1, Pre-replication complex, DNA replication origin, ORC6 and Licensing factor.
His Control of chromosome duplication study deals with the bigger picture of Genetics.
His DNA replication research is multidisciplinary, relying on both Molecular biology, Saccharomyces cerevisiae and Helicase.
His research investigates the link between Eukaryotic DNA replication and topics such as G2-M DNA damage checkpoint that cross with problems in DNA repair and DNA replication checkpoint.
He most often published in these fields:
- Cell biology (53.85%)
- Origin recognition complex (53.85%)
- Control of chromosome duplication (48.46%)
What were the highlights of his more recent work (between 2016-2021)?
- Cell biology (53.85%)
- DNA (15.38%)
- Helicase (12.31%)
In recent papers he was focusing on the following fields of study:
Cell biology, DNA, Helicase, DNA replication and Replisome are his primary areas of study.
His Cell biology study combines topics in areas such as Genetics, DNA damage and Eukaryotic DNA replication.
John F. X. Diffley studied Helicase and Origin recognition complex that intersect with DNA replication factor CDT1.
His study of Replication Initiation is a part of DNA replication.
In his research on the topic of Replisome, Polymerase and Molecular biology is strongly related with DNA polymerase.
In his work, Chromatin, Pre-replication complex and Replication factor C is strongly intertwined with DNA replication origin, which is a subfield of Minichromosome maintenance.
Between 2016 and 2021, his most popular works were:
- How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication. (174 citations)
- Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates (143 citations)
- The mechanism of eukaryotic CMG helicase activation (100 citations)
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