World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
98
Citations
31660
World Ranking
460
National Ranking
211

Molecular Biology

D-Index
98
Citations
31558
World Ranking
576
National Ranking
316

Research.com Recognitions

  • 2018 - Member of the National Academy of Sciences
  • 2005 - Fellow of the American Academy of Arts and Sciences
  • 2000 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Jack D. Griffith is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research encompasses a broad range of topics within biochemistry, genetics, molecular biology, and medicine, with particular contributions in molecular biology, epidemiology, genetics, physiology, and oncology.

Their recent publications include several studies focused on nucleic acid structures, DNA replication, and cellular mechanisms. Significant papers published are:

  • The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions, 2021, eLife
  • The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication, 2021, Science Advances
  • Imaging of surface microdomains on individual extracellular vesicles in 3-D, 2022, Journal of Extracellular Vesicles
  • Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations, 2020, Proceedings of the National Academy of Sciences
  • Mammalian telomeric RNA (TERRA) can be translated to produce valine-arginine and glycine-leucine dipeptide repeat proteins, 2023, Proceedings of the National Academy of Sciences

Their collaborative work includes frequent partnerships with several researchers, notably:

  • Smaranda Willcox
  • Alexander M. Makhov
  • Ľubomír Tomáška
  • Jozef Nosek
  • Sarah A. Compton

They have published extensively in venues such as UNC Libraries, bioRxiv (Cold Spring Harbor Laboratory), Journal of Extracellular Vesicles, Proceedings of the National Academy of Sciences, and Nucleic Acids Research.

Their research topics cover a diversity of areas, including:

  • DNA and Nucleic Acid Chemistry
  • RNA and protein synthesis mechanisms
  • Cytomegalovirus and herpesvirus research
  • Bacteriophages and microbial interactions
  • DNA Repair Mechanisms
  • Bacterial Genetics and Biotechnology
  • Telomeres, Telomerase, and Senescence

The scientist's work bridges molecular mechanisms with implications in cellular biology and disease-related processes. Their involvement in understanding DNA replication, repair, and telomere function links molecular biology with aging and genomic stability studies.

Recognition of their contributions includes prestigious honors such as:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2000
  • Fellow of the American Academy of Arts and Sciences, 2005
  • Member of the National Academy of Sciences, 2018

Best Publications

  • Mammalian Telomeres End in a Large Duplex Loop

    Jack D Griffith;Laurey Comeau;Soraya Rosenfield;Rachel M Stansel

  • Concerted Loading of Mcm2-7 Double Hexamers Around DNA during DNA Replication Origin Licensing

    Dirk Remus;Fabienne Beuron;Gökhan Tolun;Jack D. Griffith

  • T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang.

    Rachel M. Stansel;Titia de Lange;Jack D. Griffith

  • Mechanism of replication-coupled DNA interstrand crosslink repair.

    Markus Räschle;Puck Knipscheer;Milica Enoiu;Todor Angelov

  • p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

    Suman Lee;Brian Elenbaas;Arnold Levine;Jack Griffith

  • Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

    Congying Wu;Sreeja B. Asokan;Matthew E. Berginski;Elizabeth M. Haynes

  • Chromatin Structure: Deduced from a Minichromosome

    Jack D. Griffith

  • Synapsis of DNA ends by DNA‐dependent protein kinase

    Lisa G. DeFazio;Rachel M. Stansel;Rachel M. Stansel;Jack D. Griffith;Gilbert Chu

  • hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA

    Scott Gradia;Deepa Subramanian;Teresa Wilson;Samir Acharya

  • Telomeric DNA in ALT Cells Is Characterized by Free Telomeric Circles and Heterogeneous t-Loops

    Anthony J. Cesare;Jack D. Griffith

  • MutS mediates heteroduplex loop formation by a translocation mechanism

    Dwayne J. Allen;Alexander Makhov;Michelle Grilley;John Taylor

  • Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

    Vladimir P. Bermudez;Laura A. Lindsey-Boltz;Anthony J. Cesare;Yoshimasa Maniwa

  • Sticky DNA: self-association properties of long GAA.TTC repeats in R.R.Y triplex structures from Friedreich's ataxia.

    Naoaki Sakamoto;Paul D. Chastain;Pawel Parniewski;Keiichi Ohshima

  • Extrachromosomal MicroDNAs and Chromosomal Microdeletions in Normal Tissues

    Yoshiyuki Shibata;Pankaj Kumar;Ryan Layer;Smaranda Willcox

  • t-loops at trypanosome telomeres

    Jorge L. Muñoz‐Jordán;George A.M. Cross;Titia de Lange;Jack D. Griffith

  • TRF1 binds a bipartite telomeric site with extreme spatial flexibility

    Alessandro Bianchi;Alessandro Bianchi;Rachel M. Stansel;Louise Fairall;Jack D. Griffith

  • Preferential nucleosome assembly at DNA triplet repeats from the myotonic dystrophy gene

    Yuh Hwa Wang;Sorour Amirhaeri;Seongman Kang;Robert D. Wells

  • Electron Microscope Visualization of Chromatin and other DNA-Protein Complexes

    Jack D. Griffith;Gunna Christiansen

  • The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

    Tina Thorslund;Michael J McIlwraith;Sarah A Compton;Sergey Lekomtsev

  • New nomenclature and DNA testing guidelines for myotonic dystrophy type 1 (DM1)

    T. Ashizawa;I. Gonzales;N. Ohsawa;R. H. Singer

  • Visualization of the bent helix in kinetoplast DNA by electron microscopy

    Jack Griffith;Michael Bleyman;Carol A. Rauch;Peter A. Kitchin

  • Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair (DOI:10.1016/j.cell.2008.08.030)

    Markus Räschle;Puck Knipscheer;Milica Enoiu;Todor Angelov

Frequent Co-Authors

Gunna Christiansen
Gunna Christiansen Aalborg University
Aziz Sancar
Aziz Sancar University of North Carolina at Chapel Hill
Charles C. Richardson
Charles C. Richardson Harvard University
Howard T. Jacobs
Howard T. Jacobs Tampere University
Laurie S. Kaguni
Laurie S. Kaguni Michigan State University
Blossom Damania
Blossom Damania University of North Carolina at Chapel Hill
Titia de Lange
Titia de Lange Rockefeller University
Nikolay V. Dokholyan
Nikolay V. Dokholyan Pennsylvania State University
Paul T. Englund
Paul T. Englund Johns Hopkins University
Richard D. Kolodner
Richard D. Kolodner University of California, San Diego

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