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Molecular Biology

D-Index
94
Citations
27360
World Ranking
659
National Ranking
362

Overview

Timothy M. Lohman is affiliated with Washington University in St. Louis in the United States. Their primary research field is Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology, Genetics, Cell Biology, Materials Chemistry, and Plant Science.

The scientist's work centers on topics including:

  • DNA Repair Mechanisms
  • DNA and Nucleic Acid Chemistry
  • Bacterial Genetics and Biotechnology
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • RNA Research and Splicing
  • CRISPR and Genetic Engineering

Timothy M. Lohman has contributed several recent papers, spanning from 2020 to 2023. Notable publications include:

  • "How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein" (2022, Journal of Molecular Biology)
  • "Development of a single-stranded DNA-binding protein fluorescent fusion toolbox" (2020, Nucleic Acids Research)
  • "Regulation of E. coli Rep helicase activity by PriC" (2021, Journal of Molecular Biology)
  • "A new twist on PIFE: photoisomerisation-related fluorescence enhancement" (2023, Methods and Applications in Fluorescence)
  • "'Helicase' activity promoted through dynamic interactions between a ssDNA translocase and a diffusing SSB protein" (2023, Proceedings of the National Academy of Sciences)

The most frequent co-authors collaborating with Timothy M. Lohman include:

  • Binh Nguyen
  • Alexander G. Kozlov
  • Ankita Chadda
  • Eric A. Galburt
  • Linxuan Hao

The scholarly output is prominently published in several key journals with multiple contributions, such as:

  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Biology
  • Nucleic Acids Research
  • Proceedings of the National Academy of Sciences

Best Publications

  • Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity.

    Record Mt;Anderson Cf;Lohman Tm

  • Ion effects on ligand-nucleic acid interactions

    M. Thomas Record;Timothy M. Lohman;Pieter de Haseth

  • Mechanisms of helicase-catalyzed DNA unwinding.

    Timothy M. Lohman;Keith P. Bjornson

  • Escherichia coli single-stranded DNA-binding protein: multiple DNA-binding modes and cooperativities.

    Timothy M. Lohman;Marilyn E. Ferrari

  • Probing Single-Stranded DNA Conformational Flexibility Using Fluorescence Spectroscopy

    M.C. Murphy;Ivan Rasnik;Wei Cheng;Timothy M. Lohman

  • Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP.

    Sergey Korolev;John Hsieh;George H. Gauss;Timothy M. Lohman

  • SSB as an organizer/mobilizer of genome maintenance complexes

    Robert D. Shereda;Alexander G. Kozlov;Timothy M. Lohman;Michael M. Cox

  • Initiation and re-initiation of DNA unwinding by the Escherichia coli Rep helicase

    Taekjip Ha;Ivan Rasnik;Wei Cheng;Hazen P. Babcock

  • Structure of the DNA binding domain of E. coli SSB bound to ssDNA.

    Srinivasan Raghunathan;Alexander G. Kozlov;Timothy M. Lohman;Gabriel Waksman

  • A double-filter method for nitrocellulose-filter binding: application to protein-nucleic acid interactions

    Isaac Wong;Timothy M. Lohman

  • Two binding modes in Escherichia coli single strand binding protein-single stranded DNA complexes. Modulation by NaCl concentration.

    T M Lohman;L B Overman

  • Non-hexameric DNA helicases and translocases: mechanisms and regulation

    Timothy M. Lohman;Eric J. Tomko;Colin G. Wu

  • Nonspecific interaction of lac repressor with DNA: an association reaction driven by counterion release

    deHaseth Pl;Lohman Tm;Record Mt

  • Kinetic Measurement of the Step Size of DNA Unwinding by Escherichia coli UvrD Helicase

    Janid A. Ali;Timothy M. Lohman

  • Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution.

    Srinivasan Raghunathan;Cynthia S. Ricard;Timothy M. Lohman;Gabriel Waksman

  • Interpretation of monovalent and divalent cation effects on the lac repressor-operator interaction.

    Record Mt;deHaseth Pl;Lohman Tm

  • SSB protein diffusion on single-stranded DNA stimulates RecA filament formation

    Rahul Roy;Alexander G. Kozlov;Timothy M. Lohman;Taekjip Ha;Taekjip Ha

  • Repetitive shuttling of a motor protein on DNA

    Sua Myong;Ivan Rasnik;Chirlmin Joo;Timothy M. Lohman

  • Large-scale overproduction and rapid purification of the Escherichia coli ssb gene product. Expression of the ssb gene under .lambda. PL control

    Timothy M. Lohman;J. Michael Green;Richard S. Beyer

  • Allosteric effects of nucleotide cofactors on Escherichia coli Rep helicase-DNA binding.

    Isaac Wong;Timothy M. Lohman

Frequent Co-Authors

Taekjip Ha
Taekjip Ha Johns Hopkins University
Gabriel Waksman
Gabriel Waksman University College London
M. Thomas Record
M. Thomas Record University of Wisconsin–Madison
Sua Myong
Sua Myong Johns Hopkins University
Michael M. Cox
Michael M. Cox University of Wisconsin–Madison
John A. Cooper
John A. Cooper Washington University in St. Louis
Michael L. Gross
Michael L. Gross Washington University in St. Louis
Scott B. Going
Scott B. Going University of Arizona
Himadri B. Pakrasi
Himadri B. Pakrasi Washington University in St. Louis
Robert E. Blankenship
Robert E. Blankenship Washington University in St. Louis

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