World's Best Scientists 2026 revealed!
Anna Marie Pyle

Anna Marie Pyle

D-Index & Metrics

Genetics

D-Index
88
Citations
25438
World Ranking
1179
National Ranking
565

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2005 - Fellow of the American Academy of Arts and Sciences

Overview

Anna Marie Pyle is affiliated with Yale University in the United States and has a substantial body of work within Biochemistry, Genetics, and Molecular Biology, with a focus on molecular biology. Their research spans topics including RNA and protein synthesis mechanisms, RNA modifications and cancer, RNA research and splicing, interferon and immune responses, immune response and inflammation, cancer-related molecular mechanisms research, and advanced biosensing and bioanalysis techniques.

The scientist has contributed frequently to several publication venues. These include bioRxiv (Cold Spring Harbor Laboratory), where they have published 12 times, Nature Communications with 6 publications, Journal of Molecular Biology also with 6, Nucleic Acids Research with 4, and Methods in enzymology on CD-ROM/Methods in enzymology with 4 publications.

Recent papers authored or co-authored by Anna Marie Pyle include:

  • Author Correction: Visualizing group II intron dynamics between the first and second steps of splicing, 2022, Nature Communications
  • US-align: universal structure alignments of proteins, nucleic acids, and macromolecular complexes, 2022, Nature Methods
  • Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms, 2021, Molecular Cell
  • De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report, 2022, Nature Communications
  • Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes, 2021, PLoS Biology

Their frequent co-authors are:

  • Olga Fedorova
  • Chengxin Zhang
  • Han Wan
  • Rafael de Cesaris Araujo Tavares
  • Wenshuai Wang

Anna Marie Pyle's research has been recognized with fellowships from major scientific organizations. They were named a Fellow of the American Association for the Advancement of Science (AAAS) in 2007 and a Fellow of the American Academy of Arts and Sciences in 2005.

Best Publications

  • Mixed-ligand complexes of ruthenium(II): factors governing binding to DNA

    A. M. Pyle;J. P. Rehmann;R. Meshoyrer;C. V. Kumar

  • mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

    Dong Chul Kang;Rahul V. Gopalkrishnan;Rahul V. Gopalkrishnan;Qingping Wu;Qingping Wu;Eckhard Jankowsky

  • Ribozymes: a distinct class of metalloenzymes

    Anna Marie Pyle

  • Translocation and Unwinding Mechanisms of RNA and DNA Helicases

    Anna Marie Pyle

  • DNA photocleavage by phenanthrenequinone diimine complexes of rhodium(III): shape-selective recognition and reaction

    Ayesha Sitlani;Eric C. Long;Anna M. Pyle;Jacqueline K. Barton

  • Crystal structure of a self-spliced group II intron.

    Navtej Toor;Kevin S. Keating;Sean D. Taylor;Anna Marie Pyle;Anna Marie Pyle

  • Probing Nucleic Acids with Transition Metal Complexes

    Anna Marie Pyle;Jacqueline K. Barton

  • Metal ions in the structure and function of RNA.

    Anna Marie Pyle

  • Structural Insights into RNA Recognition by RIG-I

    Dahai Luo;Steve C. Ding;Adriana Vela;Andrew Kohlway

  • RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP

    Sophie Dumont;Wei Cheng;Victor Serebrov;Rudolf K. Beran

  • The Molecular Interactions That Stabilize RNA Tertiary Structure: RNA Motifs, Patterns, and Networks

    Samuel E. Butcher;Anna Marie Pyle;Anna Marie Pyle

  • Active Disruption of an RNA-Protein Interaction by a DExH/D RNA Helicase

    Eckhard Jankowsky;Christian H. Gross;Stewart Shuman;Anna Marie Pyle;Anna Marie Pyle

  • Alternative Roles for Metal Ions in Enzyme Catalysis and the Implications for Ribozyme Chemistry

    Roland K. O. Sigel;Anna Marie Pyle

  • HOTAIR Forms an Intricate and Modular Secondary Structure

    Srinivas Somarowthu;Michal Legiewicz;Isabel Chillón;Marco Marcia

  • Spring-Loaded Mechanism of DNA Unwinding by Hepatitis C Virus NS3 Helicase

    Sua Myong;Michael M. Bruno;Michael M. Bruno;Anna M. Pyle;Anna M. Pyle;Taekjip Ha

  • RNA backbone: consensus all-angle conformers and modular string nomenclature (an RNA Ontology Consortium contribution).

    Jane S. Richardson;Bohdan Schneider;Laura W. Murray;Gary J. Kapral

  • The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding.

    Phillip S. Pang;Eckhard Jankowsky;Paul J. Planet;Anna Marie Pyle;Anna Marie Pyle

  • Calculating the electrostatic properties of RNA provides new insights into molecular interactions and function

    Kevin Chin;Kim A. Sharp;Barry Honig;Anna Marie Pyle;Anna Marie Pyle

  • Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells

    Ellen F. Foxman;James A. Storer;Megan E. Fitzgerald;Bethany R. Wasik

  • The DExH protein NPH-II is a processive and directional motor for unwinding RNA.

    Eckhard Jankowsky;Christian H. Gross;Stewart Shuman;Anna Marie Pyle;Anna Marie Pyle

Frequent Co-Authors

Akiko Iwasaki
Akiko Iwasaki Yale University
Jacqueline K. Barton
Jacqueline K. Barton California Institute of Technology
Eckhard Jankowsky
Eckhard Jankowsky Case Western Reserve University
Roland K. O. Sigel
Roland K. O. Sigel University of Zurich
Brett D. Lindenbach
Brett D. Lindenbach Yale University
Craig B. Wilen
Craig B. Wilen Yale University
Thomas R. Cech
Thomas R. Cech University of Colorado Boulder
Tamar Schlick
Tamar Schlick New York University
Philip S. Perlman
Philip S. Perlman Howard Hughes Medical Institute
Samuel E. Butcher
Samuel E. Butcher University of Wisconsin–Madison

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