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D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
14108
World Ranking
7920
National Ranking
3590

Overview

Larry A. Feig is affiliated with Tufts University in the United States and has contributed to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine. Their work spans multiple subfields including Molecular Biology, Immunology, Cancer Research, Genetics, and Cognitive Neuroscience.

The scientist's research topics focus on Reproductive System and Pregnancy, MicroRNA in disease regulation, Epigenetics and DNA Methylation, Genetics and Neurodevelopmental Disorders, Autism Spectrum Disorder Research, Ubiquitin and proteasome pathways, and Neuroendocrine regulation and behavior.

They have published in various venues, with frequent contributions to bioRxiv (Cold Spring Harbor Laboratory), Epigenetics, Glia, Developmental Neurobiology, and the American Journal of Clinical Nutrition.

  • Astroglial FMRP modulates synaptic signaling and behavior phenotypes in FXS mouse model (2020, Glia)
  • Transmission of reduced levels of miR-34/449 from sperm to preimplantation embryos is a key step in the transgenerational epigenetic inheritance of the effects of paternal chronic social instability stress (2024, Epigenetics)
  • Involvement of early embryonic miR-409-3p in the establishment of anxiety levels in female mice (2020, Developmental Neurobiology)
  • Food, nutrition, and fertility: from soil to fork (2023, American Journal of Clinical Nutrition)
  • Astrocyte-Derived Exosomes Regulate Sperm miR-34c Levels to Mediate the Transgenerational Effects of Paternal Chronic Social Instability Stress (2023, bioRxiv (Cold Spring Harbor Laboratory))

Frequent collaborators in their research include Shan-Xue Jin, Alexandre Champroux, David A. Dickson, Mitra Sadat-Shirazi, and Xuan Chen.

Best Publications

  • Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

    L A Feig;G M Cooper

  • Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

    Charles L. Farnsworth;Norman W. Freshney;Laura B. Rosen;Laura B. Rosen;Anirvan Ghosh;Anirvan Ghosh

  • Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases.

    Larry A. Feig

  • Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

    Chengchao Shou;Charles L. Farnsworth;Benjamin G. Neel;Larry A. Feig

  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells

    Kian Huat Lim;Antonio T. Baines;James J. Fiordalisi;Michail Shipitsin

  • Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

    T. Urano;R. Emkey;L. A. Feig

  • Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases.

    Sharon B. Cantor;Takeshi Urano;Larry A. Feig

  • Ral-GTPases: approaching their 15 minutes of fame.

    Larry A Feig

  • Involvement of Ral GTPase in v-Src-induced phospholipase D activation

    Hong Jiang;Jing-Qing Luo;Takeshi Urano;Paul Frankel

  • Chronic social instability induces anxiety and defective social interactions across generations.

    Lorena Saavedra-Rodríguez;Larry A. Feig

  • Evidence for a Ras/Ral signaling cascade.

    Larry A. Feig;Takeshi Urano;Sharon B. Cantor

  • Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

    Jin Zhang;W. G. King;S. Dillon;A. Hall

  • Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP.

    C L Farnsworth;L A Feig

  • Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.

    David J. Robbins;Mangeng Cheng;Erzhen Zhen;Colleen A. Vanderbilt

  • Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade.

    Rachel J. Buchsbaum;Beth A. Connolly;Larry A. Feig

  • Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins.

    L A Feig;G M Cooper

  • The many roads that lead to Ras.

    Larry A. Feig

  • Transgenerational Rescue of a Genetic Defect in Long-Term Potentiation and Memory Formation by Juvenile Enrichment

    Junko A. Arai;Shaomin Li;Dean M. Hartley;Larry A. Feig

  • Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

    Dennis W. Stacey;Larry A. Feig;Jackson B. Gibbs

  • Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.

    Shaomin Li;Xuejun Tian;Dean M. Hartley;Larry A. Feig

Frequent Co-Authors

David A. Foster
David A. Foster City University of New York
Takeshi Urano
Takeshi Urano Shimane University
Geoffrey M. Cooper
Geoffrey M. Cooper Boston University
Thomas M. Roberts
Thomas M. Roberts Harvard University
Hong Jiang
Hong Jiang Central South University
Zhimin Lu
Zhimin Lu Zhejiang University
Michael Klagsbrun
Michael Klagsbrun Boston Children's Hospital
Alexander Dityatev
Alexander Dityatev German Center for Neurodegenerative Diseases
Michael E. Greenberg
Michael E. Greenberg Harvard University
Jamie Maguire
Jamie Maguire Tufts University

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