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Alfred Wittinghofer

Alfred Wittinghofer

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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
126
Citations
59060
World Ranking
493
National Ranking
33

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2001 - Member of Academia Europaea

Overview

Alfred Wittinghofer is affiliated with the Max Planck Society in Germany. Their academic research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with focused work in several subfields including Genetics, Molecular Biology, Cellular and Molecular Neuroscience, and Cell Biology.

The scientist's recent publications reflect a range of topics within these fields. Notable papers include "Structure of the human BBSome core complex" (2020, eLife) and "Pierre Chardin, un pionnier de la découverte des gènes et protéines de la superfamille Ras" (2020, médecine/sciences).

The main topics addressed in their research include:

  • Genetic and Kidney Cyst Diseases
  • Renal and related cancers
  • Genetic Syndromes and Imprinting
  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Endoplasmic Reticulum Stress and Disease

Frequent coauthors collaborating with Alfred Wittinghofer are:

  • B.U. Klink
  • Christos Gatsogiannis
  • Oliver Hofnagel
  • Stefan Raunser
  • Hélène Barelli

Alfred Wittinghofer's work has been published in various scientific venues. The frequent publication outlets include:

  • eLife
  • médecine/sciences

In recognition of academic contributions, Alfred Wittinghofer was made a Member of Academia Europaea in 2001.

Best Publications

  • The P-loop--a common motif in ATP- and GTP-binding proteins.

    Matti Saraste;Peter R. Sibbald;Alfred Wittinghofer

  • The guanine nucleotide-binding switch in three dimensions.

    Ingrid R. Vetter;Alfred Wittinghofer

  • Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

    J. de Rooij;F. J. T. Zwartkruis;M. H. G. Verheijen;R. H. Cool

  • GEFs and GAPs: Critical Elements in the Control of Small G Proteins

    Johannes L. Bos;Holger Rehmann;Alfred Wittinghofer

  • The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

    Klaus Scheffzek;Mohammad Reza Ahmadian;Wolfgang Kabsch;Lisa Wiesmüller

  • Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution : implications for the mechanism of GTP hydrolysis

    Emil F. Pai;Ute Krengel;Gregory A. Petsko;Roger S. Goody

  • STRUCTURE OF THE GUANINE-NUCLEOTIDE-BINDING DOMAIN OF THE HA-RAS ONCOGENE PRODUCT P21 IN THE TRIPHOSPHATE CONFORMATION

    Emil F. Pai;Wolfgang Kabsch;Ute Krengel;Kenneth C. Holmes

  • An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms

    Oliver Rocks;Anna Peyker;Martin Kahms;Peter J. Verveer

  • The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.

    Nicolas Nassar;Gudrun Horn;Christian A. Herrmann;Anna Scherer

  • The ras protein family: evolutionary tree and role of conserved amino acids.

    Alfonso Valencia;Pierre Chardin;Alfred Wittinghofer;Chris Sander

  • RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

    F R Bischoff;C Klebe;J Kretschmer;A Wittinghofer

  • Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

    Gunther Zimmermann;Björn Papke;Shehab Ismail;Nachiket Vartak

  • Time−resolved X−ray crystallographic study of the conformational change in Ha−ras p21 protein on GTP hydrolysis

    Ilme Schlichting;Steven C. Almo;Gert Rapp;Keith Wilson

  • GTPase-activating proteins: helping hands to complement an active site

    Klaus Scheffzek;Mohammad Reza Ahmadian;Alfred Wittinghofer

  • Structure-function relationships of the G domain, a canonical switch motif.

    Alfred Wittinghofer;Ingrid R. Vetter

  • Kinetics of interaction of nucleotides with nucleotide-free H-ras p21.

    Jacob John;Roland Sohmen;Juergen Feuerstein;Rosita Linke

  • THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS - MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES

    Ute Krengel;Ilme Schlichting;Anna Scherer;Renate Schumann

  • Quantitative Analysis of the Complex between p21ras and the Ras-binding Domain of the Human Raf-1 Protein Kinase (∗)

    Christian Herrmann;George A. Martin;Alfred Wittinghofer

  • Structural insight into filament formation by mammalian septins

    Minhajuddin Sirajuddin;Marian Farkasovsky;Florian Hauer;Dorothee Kühlmann

  • Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

    J. de Rooij;H. Rehmann;H. Rehmann;M. van Triest;R. H. Cool

Frequent Co-Authors

Roger S. Goody
Roger S. Goody Max Planck Society
Ingrid R. Vetter
Ingrid R. Vetter Max Planck Society
Mohammad Reza Ahmadian
Mohammad Reza Ahmadian Max Planck Society
Herbert Waldmann
Herbert Waldmann Max Planck Society
Klaus Scheffzek
Klaus Scheffzek Innsbruck Medical University
Christian Herrmann
Christian Herrmann Ruhr University Bochum
Hans Robert Kalbitzer
Hans Robert Kalbitzer University of Regensburg
Wolfgang Kabsch
Wolfgang Kabsch Max Planck Society
Emil F. Pai
Emil F. Pai University of Toronto
Ilme Schlichting
Ilme Schlichting Max Planck Society

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