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Alfred Wittinghofer

Alfred Wittinghofer

Max Planck Society
Germany

Award Badge
Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
126
Citations
59060
World Ranking
493
National Ranking
33

Alfred Wittinghofer publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Alfred Wittinghofer sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 533 publications — 96th percentile

96% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Alfred Wittinghofer D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Alfred Wittinghofer sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 126 D-Index — 98th percentile

98% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2001 - Member of Academia Europaea

Overview

Alfred Wittinghofer is affiliated with the Max Planck Society in Germany. Their academic research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with focused work in several subfields including Genetics, Molecular Biology, Cellular and Molecular Neuroscience, and Cell Biology.

The scientist's recent publications reflect a range of topics within these fields. Notable papers include "Structure of the human BBSome core complex" (2020, eLife) and "Pierre Chardin, un pionnier de la découverte des gènes et protéines de la superfamille Ras" (2020, médecine/sciences).

The main topics addressed in their research include:

  • Genetic and Kidney Cyst Diseases
  • Renal and related cancers
  • Genetic Syndromes and Imprinting
  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Endoplasmic Reticulum Stress and Disease

Frequent coauthors collaborating with Alfred Wittinghofer are:

  • B.U. Klink
  • Christos Gatsogiannis
  • Oliver Hofnagel
  • Stefan Raunser
  • Hélène Barelli

Alfred Wittinghofer's work has been published in various scientific venues. The frequent publication outlets include:

  • eLife
  • médecine/sciences

In recognition of academic contributions, Alfred Wittinghofer was made a Member of Academia Europaea in 2001.

Best Publications

  • The P-loop--a common motif in ATP- and GTP-binding proteins.

    Matti Saraste;Peter R. Sibbald;Alfred Wittinghofer

  • The guanine nucleotide-binding switch in three dimensions.

    Ingrid R. Vetter;Alfred Wittinghofer

  • Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

    J. de Rooij;F. J. T. Zwartkruis;M. H. G. Verheijen;R. H. Cool

  • GEFs and GAPs: Critical Elements in the Control of Small G Proteins

    Johannes L. Bos;Holger Rehmann;Alfred Wittinghofer

  • The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

    Klaus Scheffzek;Mohammad Reza Ahmadian;Wolfgang Kabsch;Lisa Wiesmüller

  • Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution : implications for the mechanism of GTP hydrolysis

    Emil F. Pai;Ute Krengel;Gregory A. Petsko;Roger S. Goody

  • STRUCTURE OF THE GUANINE-NUCLEOTIDE-BINDING DOMAIN OF THE HA-RAS ONCOGENE PRODUCT P21 IN THE TRIPHOSPHATE CONFORMATION

    Emil F. Pai;Wolfgang Kabsch;Ute Krengel;Kenneth C. Holmes

  • An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms

    Oliver Rocks;Anna Peyker;Martin Kahms;Peter J. Verveer

  • The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.

    Nicolas Nassar;Gudrun Horn;Christian A. Herrmann;Anna Scherer

  • The ras protein family: evolutionary tree and role of conserved amino acids.

    Alfonso Valencia;Pierre Chardin;Alfred Wittinghofer;Chris Sander

  • RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

    F R Bischoff;C Klebe;J Kretschmer;A Wittinghofer

  • Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

    Gunther Zimmermann;Björn Papke;Shehab Ismail;Nachiket Vartak

  • Time−resolved X−ray crystallographic study of the conformational change in Ha−ras p21 protein on GTP hydrolysis

    Ilme Schlichting;Steven C. Almo;Gert Rapp;Keith Wilson

  • GTPase-activating proteins: helping hands to complement an active site

    Klaus Scheffzek;Mohammad Reza Ahmadian;Alfred Wittinghofer

  • Structure-function relationships of the G domain, a canonical switch motif.

    Alfred Wittinghofer;Ingrid R. Vetter

  • Kinetics of interaction of nucleotides with nucleotide-free H-ras p21.

    Jacob John;Roland Sohmen;Juergen Feuerstein;Rosita Linke

  • THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS - MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES

    Ute Krengel;Ilme Schlichting;Anna Scherer;Renate Schumann

  • Quantitative Analysis of the Complex between p21ras and the Ras-binding Domain of the Human Raf-1 Protein Kinase (∗)

    Christian Herrmann;George A. Martin;Alfred Wittinghofer

  • Structural insight into filament formation by mammalian septins

    Minhajuddin Sirajuddin;Marian Farkasovsky;Florian Hauer;Dorothee Kühlmann

  • Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

    J. de Rooij;H. Rehmann;H. Rehmann;M. van Triest;R. H. Cool

Frequent Co-Authors

Roger S. Goody
Roger S. Goody Max Planck Society
Ingrid R. Vetter
Ingrid R. Vetter Max Planck Society
Mohammad Reza Ahmadian
Mohammad Reza Ahmadian Max Planck Society
Herbert Waldmann
Herbert Waldmann Max Planck Society
Klaus Scheffzek
Klaus Scheffzek Innsbruck Medical University
Christian Herrmann
Christian Herrmann Ruhr University Bochum
Hans Robert Kalbitzer
Hans Robert Kalbitzer University of Regensburg
Wolfgang Kabsch
Wolfgang Kabsch Max Planck Society
Emil F. Pai
Emil F. Pai University of Toronto
Ilme Schlichting
Ilme Schlichting Max Planck Society

External Links

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Best Scientists Citing Alfred Wittinghofer

Herbert Waldmann

Herbert Waldmann

Max Planck Society

Publications: 129

Channing J. Der

Channing J. Der

University of North Carolina at Chapel Hill

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Roger S. Goody

Roger S. Goody

Max Planck Society

Publications: 95

Johannes L. Bos

Johannes L. Bos

Utrecht University

Publications: 82

Christian Herrmann

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Ruhr University Bochum

Publications: 74

Frank McCormick

Frank McCormick

University of California, San Francisco

Publications: 72

Ruth Nussinov

Ruth Nussinov

National Institutes of Health

Publications: 72

Hans Robert Kalbitzer

Hans Robert Kalbitzer

University of Regensburg

Publications: 56

John F. Hancock

John F. Hancock

The University of Texas Health Science Center at Houston

Publications: 55

Klaus Gerwert

Klaus Gerwert

Ruhr University Bochum

Publications: 53

Richard A. Kahn

Richard A. Kahn

Emory University

Publications: 50

Klaus Aktories

Klaus Aktories

University of Freiburg

Publications: 49

Mark R. Philips

Mark R. Philips

New York University

Publications: 43

Holger Rehmann

Holger Rehmann

Utrecht University

Publications: 40

Tohru Kataoka

Tohru Kataoka

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Sharon L. Campbell

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