2023 - Research.com Biology and Biochemistry in Germany Leader Award
2001 - Member of Academia Europaea
Alfred Wittinghofer spends much of his time researching Biochemistry, GTPase, GTP', Protein structure and Cell biology. Alfred Wittinghofer frequently studies issues relating to Biophysics and Biochemistry. His research in GTPase intersects with topics in GTPase-activating protein, Binding domain, Mutant and Catalysis, Active site.
His studies in GTP' integrate themes in fields like Ran, Crystallography, Binding protein and Stereochemistry. His Protein structure study integrates concerns from other disciplines, such as Threonine, Conformational change, Gap gene and Peptide sequence. His work on Signal transduction and Actin as part of general Cell biology research is frequently linked to Nodose Ganglion and Dorsal root ganglion, bridging the gap between disciplines.
Alfred Wittinghofer mostly deals with Biochemistry, GTPase, Cell biology, GTP' and Stereochemistry. His is doing research in Protein structure, Nucleotide, Guanine nucleotide exchange factor, G protein and Binding site, both of which are found in Biochemistry. His research integrates issues of GTP-binding protein regulators, GTPase-activating protein, Biophysics, Mutant and Active site in his study of GTPase.
The study incorporates disciplines such as Ran, Small G Protein and Rap1 in addition to GTPase-activating protein. His study in GTP' is interdisciplinary in nature, drawing from both Crystallography and Guanosine. His study in EF-Tu extends to Stereochemistry with its themes.
His primary areas of study are Cell biology, Biochemistry, GTPase, G protein and Cilium. In general Cell biology, his work in GTPase-activating protein, Plasma protein binding, Effector and Myristoylation is often linked to ADP ribosylation factor linking many areas of study. His work deals with themes such as Small G Protein, Conformational change, Guanosine triphosphate and Myxococcus xanthus, which intersect with GTPase-activating protein.
His GTPase research includes themes of Protein structure, Computational biology, G-domain and Function. His study in G protein is interdisciplinary in nature, drawing from both Biophysics and GTP'. His work in Biophysics covers topics such as Protein filament which are related to areas like Nucleotide.
Alfred Wittinghofer mainly investigates Cell biology, Plasma protein binding, GTPase-activating protein, G protein and GTPase. His research in the fields of Cilium and Transport protein overlaps with other disciplines such as ADP ribosylation factor and Cell polarity. His Plasma protein binding study combines topics in areas such as Protein structure, Signal transduction and Prenylation.
He usually deals with GTPase-activating protein and limits it to topics linked to GTP' and Motility. His studies in G protein integrate themes in fields like Nucleotide, Guanine, Protein filament, DNA-binding protein and Septin. His GTPase research is under the purview of Biochemistry.
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The P-loop--a common motif in ATP- and GTP-binding proteins.
Matti Saraste;Peter R. Sibbald;Alfred Wittinghofer.
Trends in Biochemical Sciences (1990)
The guanine nucleotide-binding switch in three dimensions.
Ingrid R. Vetter;Alfred Wittinghofer.
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
J. de Rooij;F. J. T. Zwartkruis;M. H. G. Verheijen;R. H. Cool.
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
Johannes L. Bos;Holger Rehmann;Alfred Wittinghofer.
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
Klaus Scheffzek;Mohammad Reza Ahmadian;Wolfgang Kabsch;Lisa Wiesmüller.
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution : implications for the mechanism of GTP hydrolysis
Emil F. Pai;Ute Krengel;Gregory A. Petsko;Roger S. Goody.
The EMBO Journal (1990)
STRUCTURE OF THE GUANINE-NUCLEOTIDE-BINDING DOMAIN OF THE HA-RAS ONCOGENE PRODUCT P21 IN THE TRIPHOSPHATE CONFORMATION
Emil F. Pai;Wolfgang Kabsch;Ute Krengel;Kenneth C. Holmes.
An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms
Oliver Rocks;Anna Peyker;Martin Kahms;Peter J. Verveer.
The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.
Nicolas Nassar;Gudrun Horn;Christian A. Herrmann;Anna Scherer.
The ras protein family: evolutionary tree and role of conserved amino acids.
Alfonso Valencia;Pierre Chardin;Alfred Wittinghofer;Chris Sander.
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