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Biology and Biochemistry

D-Index
55
Citations
13002
World Ranking
14902
National Ranking
136

Overview

Klaus Scheffzek is affiliated with Innsbruck Medical University in Austria. Their research spans several areas within biochemistry, genetics, molecular biology, and medicine, focusing particularly on molecular biology, neurology, cell biology, and materials chemistry.

Their scholarly work covers a variety of topics including:

  • Fibroblast Growth Factor Research
  • Hippo pathway signaling and YAP/TAZ
  • Wnt/β-catenin signaling in development and cancer
  • Neuroblastoma Research and Treatments
  • Neurofibromatosis and Schwannoma Cases
  • Signaling Pathways in Disease
  • Mechanisms of cancer metastasis

Frequent collaborators of Klaus Scheffzek include Sebastiaan Werten, Theresia Dunzendorfer-Matt, Wupeng Yan, Evan Markegard, and Srisathiyanarayanan Dharmaiah.

Scheffzek has contributed to research published in various scientific journals. The main venues where their work appears are:

  • Cell Reports
  • Molecular Cell
  • International Journal of Molecular Sciences

Examples of recent publications are:

  • Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR, 2020, Cell Reports
  • Structural basis of activation of the tumor suppressor protein neurofibromin, 2022, Molecular Cell
  • Mechanistic Insights into Substrate Recognition of Human Nucleoside Diphosphate Kinase C Based on Nucleotide-Induced Structural Changes, 2024, International Journal of Molecular Sciences

Their work emphasizes structural and mechanistic understanding of protein complexes relevant to cancer biology and molecular signaling pathways. Central to their publications are molecular mechanisms involved in tumor suppressor activation, substrate recognition of enzymes, and pathway disruptions linked with oncogenic mutations.

Best Publications

  • The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

    Klaus Scheffzek;Mohammad Reza Ahmadian;Wolfgang Kabsch;Lisa Wiesmüller

  • Structural basis for the autoinhibition of c-Abl tyrosine kinase

    Bhushan Nagar;Oliver Hantschel;Matthew A. Young;Klaus Scheffzek

  • GTPase-activating proteins: helping hands to complement an active site

    Klaus Scheffzek;Mohammad Reza Ahmadian;Alfred Wittinghofer

  • Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

    Mohammad Reza Ahmadian;Patricia Stege;Klaus Scheffzek;Alfred Wittinghofer

  • A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.

    Gyula Timinszky;Susanne Till;Paul O Hassa;Michael Hothorn

  • Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

    Thomas Schweins;Matthias Geyer;Klaus Scheffzek;Arieh Warshel

  • Splicing regulates NAD metabolite binding to histone macroH2A.

    Georg Kustatscher;Michael Hothorn;Céline Pugieux;Klaus Scheffzek

  • Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.

    Michael Hothorn;Heinz Neumann;Esther D. Lenherr;Mark Wehner

  • Mutations in SYNGAP1 Cause Intellectual Disability, Autism, and a Specific Form of Epilepsy by Inducing Haploinsufficiency

    Martin H. Berryer;Fadi F. Hamdan;Laura L. Klitten;Rikke S. Møller

  • The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.

    Klaus Scheffzek;Ilona Stephan;Ole N. Jensen;Daria Illenberger

  • Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.

    Klaus Scheffzek;Christian Klebe;Karin Fritz-Wolf;Wolfgang Kabsch

  • Crystal structure of the alpha-actinin rod reveals an extensive torsional twist

    Jari Ylänne;Klaus Scheffzek;Paul Young;Matti Saraste

  • Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras.

    Klaus Scheffzek;Alfred Lautwein;Wolfgang Kabsch;Mohammad Reza Ahmadian

  • Structural analysis of the GAP‐related domain from neurofibromin and its implications

    Klaus Scheffzek;Mohammad Reza Ahmadian;Lisa Wiesmüller;Wolfgang Kabsch

  • GTPase activating proteins: structural and functional insights 18 years after discovery

    Klaus Scheffzek;Mohammad Reza Ahmadian

  • Selective Disactivation of Neurofibromin GAP Activity in Neurofibromatosis Type 1 (NF1)

    A. Klose;M. R. Ahmadian;M. Schuelke;K. Scheffzek

  • Guanosine triphosphatase stimulation of oncogenic Ras mutants

    Mohammad Reza Ahmadian;Tsaffrir Zor;Dorothee Vogt;Wolfgang Kabsch

  • Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE

    Gretel Buchwald;Andrea Friebel;Jorge E. Galán;Wolf-Dietrich Hardt

  • Structural insights into the target specificity of plant invertase and pectin methylesterase inhibitory proteins.

    Michael Hothorn;Sebastian Wolf;Patrick Aloy;Steffen Greiner

  • U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.

    Lorenzo Corsini;Sophie Bonnal;Jerome Basquin;Michael Hothorn

Frequent Co-Authors

Alfred Wittinghofer
Alfred Wittinghofer Max Planck Society
Michael Hothorn
Michael Hothorn University of Geneva
Mohammad Reza Ahmadian
Mohammad Reza Ahmadian Max Planck Society
Wolfgang Kabsch
Wolfgang Kabsch Max Planck Society
Vladimir Rybin
Vladimir Rybin European Molecular Biology Laboratory
Matthias Geyer
Matthias Geyer University of Bonn
Andreas G. Ladurner
Andreas G. Ladurner Ludwig-Maximilians-Universität München
Michael Sattler
Michael Sattler Technical University of Munich
Hans Robert Kalbitzer
Hans Robert Kalbitzer University of Regensburg
Roger S. Goody
Roger S. Goody Max Planck Society

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