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Roger S. Goody

Roger S. Goody

D-Index & Metrics

Chemistry

D-Index
95
Citations
27253
World Ranking
1659
National Ranking
119

Biology and Biochemistry

D-Index
95
Citations
27541
World Ranking
1940
National Ranking
130

Research.com Recognitions

  • 2018 - Fellow of the Royal Society, United Kingdom

Overview

Roger S. Goody is affiliated with the Max Planck Society in Germany and has contributed extensively to research in biochemistry, genetics, and molecular biology, with a particular focus on molecular biology and cell biology. Their work also spans materials chemistry, pharmacology, and surgery.

The scientist's research centers on topics including protein kinase regulation and GTPase signaling, ubiquitin and proteasome pathways, cellular transport and secretion, microbial natural products and biosynthesis, chemical synthesis and analysis, enzyme structure and function, as well as melanoma and MAPK pathways.

The following is a selection of recent publications by Roger S. Goody, displaying the range of topics and venues:

  • KRasG12C inhibitors in clinical trials: a short historical perspective (2020, RSC Medicinal Chemistry)
  • The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members (2020, Nature Communications)
  • The Pseudo-Natural Product Rhonin Targets RHOGDI (2022, Angewandte Chemie International Edition)
  • Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector (2022, Nature Communications)
  • Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors (2023, eLife)

The scientist frequently publishes in a range of journals, with multiple contributions to Nature Communications and Biopolymers as well as publications in bioRxiv (Cold Spring Harbor Laboratory), RSC Medicinal Chemistry, and Angewandte Chemie International Edition.

Collaborations are an integral part of Roger S. Goody's research. Frequent co-authors include Petra Janning, Amrita Rai, Matthias Müller, Daniel Rauh, and Hospital Trust, with respective collaborations ranging from four to six joint publications.

Roger S. Goody was recognized as a Fellow of the Royal Society, United Kingdom, in 2018.

Best Publications

  • The Original Michaelis Constant: Translation of the 1913 Michaelis–Menten Paper

    Kenneth A. Johnson;Roger S. Goody

  • Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 Å resolution : implications for the mechanism of GTP hydrolysis

    Emil F. Pai;Ute Krengel;Gregory A. Petsko;Roger S. Goody

  • Time−resolved X−ray crystallographic study of the conformational change in Ha−ras p21 protein on GTP hydrolysis

    Ilme Schlichting;Steven C. Almo;Gert Rapp;Keith Wilson

  • Kinetics of interaction of nucleotides with nucleotide-free H-ras p21.

    Jacob John;Roland Sohmen;Juergen Feuerstein;Rosita Linke

  • A toolkit and benchmark study for FRET-restrained high-precision structural modeling

    Stanislav Kalinin;Thomas Peulen;Simon Sindbert;Paul J Rothwell

  • The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

    Matthias P. Müller;Heide Peters;Julia Blümer;Wulf Blankenfeldt

  • GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

    Vladimir Rybin;Oliver Ullrich;Mariantonietta Rubino;Kirill A. Alexandrov

  • Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide‐binding site

    Jane Tucker;Georg Sczakiel;Jürgen Feuerstein;Jacob John

  • The magnesium ion-dependent adenosine triphosphatase of myosin. Two-step processes of adenosine triphosphate association and adenosine diphosphate dissociation.

    Clive R. Bagshaw;John F. Eccleston;Fritz Eckstein;Roger S. Goody

  • Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras.

    Jacob John;Hans Rensland;Ilme Schlichting;Ingrid R. Vetter

  • The kinetic mechanism of Ran--nucleotide exchange catalyzed by RCC1.

    Christian Klebe;Heino Prinz;Alfred Wittinghofer;Roger S. Goody

  • Structure of the N6-adenine DNA methyltransferase M.TaqI in complex with DNA and a cofactor analog.

    Karsten Goedecke;Marc Pignot;Roger S. Goody;Axel J. Scheidig

  • Synthesis and properties of diastereoisomers of adenosine 5'-(O-1-thiotriphosphate) and adenosine 5'-(O-2-thiotriphosphate).

    Fritz Eckstein;Roger S. Goody

  • Multiparameter single-molecule fluorescence spectroscopy reveals heterogeneity of HIV-1 reverse transcriptase:primer/template complexes

    Paul James Rothwell;Sylvia Berger;Oliver Kensch;Suren Felekyan

  • Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate, and GTPase-activating proteins.

    Rohit Mittal;Mohammad Reza Ahmadian;Roger S. Goody;Alfred Wittinghofer

  • The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins.

    Axel J Scheidig;Christoph Burmester;Roger S Goody

  • The Interaction of Bovine Pancreatic Deoxyribonuclease I and Skeletal Muscle Actin

    Hans Georg Mannherz;Roger S. Goody;Manfred Konrad;Ewa Nowak

  • Structure of Rab GDP-Dissociation Inhibitor in Complex with Prenylated YPT1 GTPase

    Alexey Rak;Olena Pylypenko;Thomas Durek;Anja Watzke

  • Thiophosphate analogs of nucleoside di- and triphosphates

    R. S. Goody;F. Eckstein

  • Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

    Katrin Rittinger;Gilles Divita;Roger S. Goody

  • Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention.

    T Restle;B Müller;R S Goody

Frequent Co-Authors

Kirill Alexandrov
Kirill Alexandrov Queensland University of Technology
Herbert Waldmann
Herbert Waldmann Max Planck Society
Alfred Wittinghofer
Alfred Wittinghofer Max Planck Society
Wulf Blankenfeldt
Wulf Blankenfeldt Helmholtz Centre for Infection Research
Ilme Schlichting
Ilme Schlichting Max Planck Society
Jochen Reinstein
Jochen Reinstein Max Planck Society
Gilles Divita
Gilles Divita Centre national de la recherche scientifique, CNRS
Martin Engelhard
Martin Engelhard Max Planck Society
Emil F. Pai
Emil F. Pai University of Toronto
Fritz Eckstein
Fritz Eckstein Max Planck Society

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