Miguel C. Seabra

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Portugal Leader Award
• 2025 - Research.com Biology and Biochemistry in Portugal Leader Award
• 2023 - Research.com Biology and Biochemistry in Portugal Leader Award
• 2022 - Research.com Biology and Biochemistry in Portugal Leader Award

Overview

Best Publications

• Rab27a and Rab27b control different steps of the exosome secretion pathway

  Matias Ostrowski;Nuno B. Carmo;Sophie Krumeich;Sophie Krumeich;Isabelle Fanget

  2901
  Citations

• NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells

  Ariel Savina;Carolina Jancic;Stephanie Hugues;Pierre Guermonprez

  1040
  Citations

• Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.

  Yuval Reiss;Joseph L. Goldstein;Miguel C. Seabra;Patrick J. Casey

  1024
  Citations

• Evolution of the Rab family of small GTP-binding proteins.

  José B. Pereira-Leal;Miguel C. Seabra

  971
  Citations

• Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

  Robert E MacLaren;Robert E MacLaren;Markus Groppe;Markus Groppe;Alun R Barnard;Charles L Cottriall

  869
  Citations

• Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

  Margaret Alexander;Ruozhen Hu;Marah C. Runtsch;Dominique A. Kagele

  736
  Citations

• Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

  Angélique Bobrie;Sophie Krumeich;Fabien Reyal;Chiara Recchi

  650
  Citations

• MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells.

  Isobel S. Okoye;Stephanie M. Coomes;Victoria S. Pelly;Stephanie Czieso

  637
  Citations

• The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.

  José B Pereira-Leal;Miguel C Seabra

  579
  Citations

• Rab GTPases, intracellular traffic and disease.

  Miguel C Seabra;Emilie H Mules;Alistair N Hume

  569
  Citations

• The melanosome: membrane dynamics in black and white.

  Michael S. Marks;Miguel C. Seabra

  530
  Citations

• Structurally Distinct Membrane Nanotubes between Human Macrophages Support Long-Distance Vesicular Traffic or Surfing of Bacteria

  Björn Önfelt;Shlomo Nedvetzki;Richard K. P. Benninger;Marco A. Purbhoo

  499
  Citations

• Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit

  Miguel C. Seabra;Yuval Reiss;Patrick J. Casey;Michael S. Brown

  476
  Citations

• Rab27a is required for regulated secretion in cytotoxic T lymphocytes.

  Jane C. Stinchcombe;Duarte C. Barral;Emilie H. Mules;Sarah Booth

  461
  Citations

• cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein

  Douglas A. Andres;Miguel C. Seabra;Michael S. Brown;Scott A. Armstrong

  429
  Citations

• Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.

  Miguel C. Seabra;Joseph L. Goldstein;Thomas C. Südhof;Thomas C. Südhof;Michael S. Brown

  421
  Citations

• Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages

  Fraser P. Coxon;Miep H. Helfrich;Banafshe Larijani;Mariusz Muzylak

  418
  Citations

• Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.

  Miguel C. Seabra;Michael S. Brown;Clive A. Slaughter;Clive A. Slaughter;Thomas C. Südhof;Thomas C. Südhof

  407
  Citations

• GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

  Vladimir Rybin;Oliver Ullrich;Mariantonietta Rubino;Kirill A. Alexandrov

  403
  Citations

• Controlling the location and activation of Rab GTPases.

  Miguel C Seabra;Christina Wasmeier

  400
  Citations