2022 - Research.com Biology and Biochemistry in Portugal Leader Award
His primary scientific interests are in Cell biology, Rab, Biochemistry, Endosome and RAB27. His Cell biology research is multidisciplinary, incorporating elements of Microvesicles, Vesicular transport protein, Immune system, Antigen and Melanosome. The study incorporates disciplines such as Transport protein, Prenylation and Choroideremia in addition to Rab.
His Endosome research is multidisciplinary, incorporating perspectives in Exosome and Nocodazole. His study in Exosome is interdisciplinary in nature, drawing from both Secretion, Cancer research, Exosomal secretion and Immunology. His work deals with themes such as Ras superfamily, Melanophilin and Melanosome transport, which intersect with RAB27.
The scientist’s investigation covers issues in Cell biology, Rab, Choroideremia, GTPase and Biochemistry. Miguel C. Seabra has included themes like Retinal pigment epithelium, Secretion and Melanosome in his Cell biology study. His Retinal pigment epithelium research incorporates themes from Phagosome and Pathology.
His research investigates the connection between Rab and topics such as Prenylation that intersect with issues in Stereochemistry and GTP-binding protein regulators. His Choroideremia research includes elements of Retinal degeneration and Genetic enhancement. His studies in GTPase integrate themes in fields like GTP', Guanosine triphosphate and Effector.
Miguel C. Seabra mainly investigates Cell biology, Retinal, Choroideremia, Ophthalmology and Retinal pigment epithelium. His biological study focuses on Rab. The concepts of his Rab study are interwoven with issues in Proteome, Proteomics and Geranylgeranylation.
Miguel C. Seabra interconnects Macular degeneration and Pathology in the investigation of issues within Retinal. His Choroideremia research is multidisciplinary, relying on both Retinal degeneration, Retina and Genetic enhancement. His Retinal pigment epithelium research incorporates elements of Endoplasmic reticulum, Inner ear, Basal and Osmotic shock.
Cell biology, Endocytic cycle, Choroideremia, Genetic enhancement and Visual acuity are his primary areas of study. His Cell biology research integrates issues from Microvesicles, ATG5 and Immune system. His research in Endocytic cycle intersects with topics in Parasite load, Liver infection, Intracellular parasite and Plasmodium berghei.
His studies deal with areas such as Clinical endpoint, Clinical trial and Cohort as well as Choroideremia. His work carried out in the field of Genetic enhancement brings together such families of science as Retinal degeneration, Optometry, Microperimetry and Adverse effect. His Visual acuity study combines topics from a wide range of disciplines, such as Retinal pigment epithelium, Retina and Phases of clinical research.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Rab27a and Rab27b control different steps of the exosome secretion pathway
Matias Ostrowski;Nuno B. Carmo;Sophie Krumeich;Sophie Krumeich;Isabelle Fanget.
Nature Cell Biology (2010)
Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.
Yuval Reiss;Joseph L. Goldstein;Miguel C. Seabra;Patrick J. Casey.
Cell (1990)
Evolution of the Rab family of small GTP-binding proteins.
José B. Pereira-Leal;Miguel C. Seabra.
Journal of Molecular Biology (2001)
NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells
Ariel Savina;Carolina Jancic;Stephanie Hugues;Pierre Guermonprez.
Cell (2006)
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial
Robert E MacLaren;Robert E MacLaren;Markus Groppe;Markus Groppe;Alun R Barnard;Charles L Cottriall.
The Lancet (2014)
Rab GTPases, intracellular traffic and disease.
Miguel C Seabra;Emilie H Mules;Alistair N Hume.
Trends in Molecular Medicine (2002)
The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.
José B Pereira-Leal;Miguel C Seabra.
Journal of Molecular Biology (2000)
The melanosome: membrane dynamics in black and white.
Michael S. Marks;Miguel C. Seabra.
Nature Reviews Molecular Cell Biology (2001)
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
Margaret Alexander;Ruozhen Hu;Marah C. Runtsch;Dominique A. Kagele.
Nature Communications (2015)
Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression
Angélique Bobrie;Sophie Krumeich;Fabien Reyal;Chiara Recchi.
Cancer Research (2012)
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