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Neuroscience

D-Index
47
Citations
10599
World Ranking
6358
National Ranking
2771

Overview

Todd Charlton Sacktor is affiliated with SUNY Downstate Medical Center in the United States. Their research focuses primarily on neuroscience, with significant contributions to cellular and molecular neuroscience, cognitive neuroscience, cell biology, molecular biology, and neurology.

Their work extensively covers topics related to neuroscience and neuropharmacology research, memory and neural mechanisms, photoreceptor and optogenetics research, Alzheimer's disease research and treatments, autophagy in disease and therapy, cellular transport and secretion, and neuroinflammation and neurodegeneration mechanisms.

Recent publications by Sacktor include the following:

  • Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage, 2021, European Journal of Neuroscience
  • KIBRA anchoring the action of PKMζ maintains the persistence of memory, 2024, Science Advances
  • KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss, 2024, Journal of Clinical Investigation
  • Lifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care, 2021, Learning & Memory
  • Conditions for Synaptic Specificity during the Maintenance Phase of Synaptic Plasticity, 2022, eNeuro

Sacktor's frequent coauthors include Changchi Hsieh, Panayiotis Tsokas, Rafael E. Flores-Obando, André A. Fenton, and Peter J. Bergold. They have collaborated with these researchers on several projects.

The scientist's research has been published in various venues, with recurring appearances in bioRxiv (Cold Spring Harbor Laboratory), Learning & Memory, Science Advances, European Journal of Neuroscience, and Journal of Clinical Investigation.

Best Publications

  • Storage of Spatial Information by the Maintenance Mechanism of LTP

    Eva Pastalkova;Peter Serrano;Deana Pinkhasova;Emma Wallace

  • How does PKMζ maintain long-term memory?

    Todd C. Sacktor

  • Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation

    Todd Charlton Sacktor;Pavel Osten;Helen Valsamis;Xiaolan Jiang

  • Protein kinase Mζ is necessary and sufficient for LTP maintenance

    Douglas S.F. Ling;Larry S. Benardo;Peter A. Serrano;Nancy Blace

  • Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMζ

    Reut Shema;Todd Charlton Sacktor;Todd Charlton Sacktor;Yadin Dudai;Yadin Dudai

  • PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking

    Paola Virginia Migues;Oliver Hardt;Dong Chuan Wu;Karine Gamache

  • Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memory.

    A.Ivan Hernandez;Nancy Blace;John F. Crary;Peter A. Serrano

  • PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories

    Peter Serrano;Eugenia L Friedman;Jana Kenney;Stephen M Taubenfeld

  • PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors

    Yudong Yao;Matthew Taylor Kelly;Sreedharan Sajikumar;Peter Serrano

  • PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage.

    Todd Charlton Sacktor

  • Persistent Phosphorylation by Protein Kinase Mζ Maintains Late-Phase Long-Term Potentiation

    Peter Serrano;Yudong Yao;Todd Charlton Sacktor

  • Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease

    Charles Y. Shao;Suzanne S. Mirra;Hameetha B. R. Sait;Todd C. Sacktor

  • Synaptic Tagging and Cross-Tagging: The Role of Protein Kinase Mζ in Maintaining Long-Term Potentiation But Not Long-Term Depression

    Sreedharan Sajikumar;Sheeja Navakkode;Todd Charlton Sacktor;Julietta Uta Frey

  • PROTEIN SYNTHESIS-DEPENDENT FORMATION OF PROTEIN KINASE MZETA IN LONG-TERM POTENTIATION

    P Osten;L Valsamis;A Harris;TC Sacktor

  • Bidirectional Regulation of Protein Kinase Mζ in the Maintenance of Long-Term Potentiation and Long-Term Depression

    Sabina Hrabetova;Todd Charlton Sacktor

  • Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis

    Zhifang Dong;Huili Han;Hongjie Li;Yanrui Bai

  • Enhancement of Consolidated Long-Term Memory by Overexpression of Protein Kinase Mζ in the Neocortex

    Reut Shema;Sharon Haramati;Shiri Ron;Shoshi Hazvi

  • Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster.

    Eric A. Drier;Marcela K. Tello;Marcela K. Tello;Maureen Cowan;Priscilla Wu

  • Distinct NMDA Receptor Subpopulations Contribute to Long-Term Potentiation and Long-Term Depression Induction

    Sabina Hrabetova;Peter Serrano;Nancy Blace;Heong W. Tse

  • Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice.

    Panayiotis Tsokas;Changchi Hsieh;Yudong Yao;Edith Lesburguères

  • Regulation of protein kinase Mζ synthesis by multiple kinases in long-term potentiation

    Matthew Taylor Kelly;John Fonda Crary;Todd Charlton Sacktor

Frequent Co-Authors

André A. Fenton
André A. Fenton New York University
Pavel Osten
Pavel Osten Cold Spring Harbor Laboratory
Bong-Kiun Kaang
Bong-Kiun Kaang Seoul National University
Yadin Dudai
Yadin Dudai Weizmann Institute of Science
Julietta Uta Frey
Julietta Uta Frey Leibniz Institute for Neurobiology
Bai Lu
Bai Lu Tsinghua University
Stephen Maren
Stephen Maren University of Illinois at Urbana-Champaign
Ann E. Kelley
Ann E. Kelley University of Wisconsin–Madison
Cristina M. Alberini
Cristina M. Alberini New York University
Jerry W. Rudy
Jerry W. Rudy University of Colorado Boulder

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