2023 - Research.com Biology and Biochemistry in United States Leader Award
2022 - Research.com Best Scientist Award
2022 - Research.com Biology and Biochemistry in United States Leader Award
2019 - Fellow, National Academy of Inventors
2007 - Member of the European Academy of Sciences
2003 - Albany Medical Center Prize in Medicine and Biomedical Research
2003 - Distinguished Scientist Award, American Heart Association
1999 - Warren Alpert Foundation Prize For their research in the development of statins which lower the level of cholesterol in the heart.
1991 - Fellow of the Royal Society, United Kingdom
1990 - Fellow of the American Association for the Advancement of Science (AAAS)
1988 - US President's National Medal of Science "For their historic discovery of the basic mechanisms controlling cholesterol metabolism, opening the way to a new pharmacologic approach to the treatment of cardiovascular disease, the leading cause of death and disability in the Western world.", Presented by President Reagan in a White House ceremony on July 15, 1988. Awarded jointly with Dr. Michael S. Brown, University of Texas Southwestern Medical Center.
1987 - Member of the National Academy of Medicine (NAM)
1985 - Nobel Prize for their discoveries concerning the regulation of cholesterol metabolism
1985 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
1985 - William Allan Award, the American Society of Human Genetics
1984 - Louisa Gross Horwitz Prize, Columbia University
1981 - Fellow of the American Academy of Arts and Sciences
1981 - Canada Gairdner International Award
1980 - Member of the National Academy of Sciences
1979 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for their work in cholesterol biosynthesis.
Member of the Association of American Physicians
His primary areas of study are Biochemistry, Internal medicine, Endocrinology, LDL receptor and Cholesterol. Biochemistry is often connected to Cell biology in his work. His Internal medicine study frequently draws connections to adjacent fields such as Signal transduction.
Joseph L. Goldstein has researched LDL receptor in several fields, including Receptor, Endocytosis, Familial hypercholesterolemia and Low-density lipoprotein. His Cholesterol study combines topics from a wide range of disciplines, such as Reductase, Coenzyme A, HMG-CoA reductase, Hyperlipidemia and Arteriosclerosis. He has included themes like Molecular biology and Endoplasmic reticulum in his Sterol regulatory element-binding protein study.
His primary areas of investigation include Biochemistry, LDL receptor, Internal medicine, Cholesterol and Endocrinology. His Biochemistry study frequently links to adjacent areas such as Molecular biology. His LDL receptor study integrates concerns from other disciplines, such as Receptor, Cell surface receptor, Familial hypercholesterolemia and Low-density lipoprotein.
His studies in Low-density lipoprotein integrate themes in fields like Intermediate-density lipoprotein, Endocytosis and Low-density lipoprotein receptor gene family. His research links Hyperlipidemia with Internal medicine. His Cholesterol study combines topics in areas such as NPC1, Binding site and HMG-CoA reductase.
His main research concerns Biochemistry, Cholesterol, Endocrinology, Internal medicine and Ghrelin. His research related to Endoplasmic reticulum, Membrane protein, Sterol regulatory element-binding protein, Cholesterol binding and Cholesterol 7 alpha-hydroxylase might be considered part of Biochemistry. Joseph L. Goldstein combines subjects such as Biophysics, Cell biology, Binding site and NPC1 with his study of Cholesterol.
His Binding site research is multidisciplinary, incorporating perspectives in Endocytosis and Chinese hamster ovary cell. In his study, Molecular biology is strongly linked to Amino acid, which falls under the umbrella field of NPC1. His work on Receptor expands to the thematically related Endocrinology.
Joseph L. Goldstein focuses on Cholesterol, Biochemistry, Internal medicine, Endocrinology and Endoplasmic reticulum. Joseph L. Goldstein interconnects Endocytosis and Binding site in the investigation of issues within Cholesterol. The concepts of his Endocrinology study are interwoven with issues in Signal transduction, Transgene and Fatty acid.
His work in Endoplasmic reticulum covers topics such as Membrane protein which are related to areas like Transport protein, COPII, Protein Sorting Signals, COP-Coated Vesicles and Plasma protein binding. His Sterol research includes elements of Transcription factor and HMG-CoA reductase. His LDL receptor research incorporates themes from Familial hypercholesterolemia, Receptor recycling and Receptor-mediated endocytosis.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
A receptor-mediated pathway for cholesterol homeostasis.
Michael S. Brown;Joseph L. Goldstein.
Science (1986)
Regulation of the mevalonate pathway.
Joseph L. Goldstein;Michael S. Brown.
Nature (1990)
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Jay D. Horton;Joseph L. Goldstein;Michael S. Brown.
Journal of Clinical Investigation (2002)
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
Michael S Brown;Joseph L Goldstein.
Cell (1997)
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
Joseph L. Goldstein;Y. K. Ho;Sandip K. Basu;Michael S. Brown.
Proceedings of the National Academy of Sciences of the United States of America (1979)
Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
Michael S. Brown;Joseph L. Goldstein.
Annual Review of Biochemistry (1983)
The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
J. L. Goldstein;M. S. Brown.
Annual Review of Biochemistry (1977)
Coated pits, coated vesicles, and receptor-mediated endocytosis
Joseph L. Goldstein;Richard G. W. Anderson;Michael S. Brown.
Nature (1979)
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
Joyce J. Repa;Guosheng Liang;Jiafu Ou;Yuriy Bashmakov.
Genes & Development (2000)
Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
Joseph L. Goldstein;Michael S. Brown;Richard G. W. Anderson;David W. Russell.
Annual Review of Cell Biology (1985)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:
The University of Texas Southwestern Medical Center
The University of Texas Southwestern Medical Center
University of Washington
Pacific Biosciences (United States)
The University of Texas Southwestern Medical Center
Stanford University
The University of Texas Southwestern Medical Center
Universidade Nova de Lisboa
University of Tokyo
University of Georgia
University of Twente
University of Bremen
Swiss Federal Laboratories for Materials Science and Technology
University of Parma
Shanghai Jiao Tong University
Northwestern Polytechnical University
Centre national de la recherche scientifique, CNRS
University of California, Davis
University of Copenhagen
Novartis (United States)
Southern Cross University
United States Geological Survey
Harbor Branch Oceanographic Institute
National University of Singapore
National University of Singapore
University of Helsinki