D-Index & Metrics Best Publications
Research.com 2022 Best Scientist Award Badge
Biology and Biochemistry
USA
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Best Scientists D-index 234 Citations 207,440 578 World Ranking 57 National Ranking 40
Biology and Biochemistry D-index 237 Citations 208,169 554 World Ranking 5 National Ranking 3

Research.com Recognitions

Awards & Achievements

2023 - Research.com Biology and Biochemistry in United States Leader Award

2022 - Research.com Best Scientist Award

2022 - Research.com Biology and Biochemistry in United States Leader Award

2019 - Fellow, National Academy of Inventors

2007 - Member of the European Academy of Sciences

2003 - Albany Medical Center Prize in Medicine and Biomedical Research

2003 - Distinguished Scientist Award, American Heart Association

1999 - Warren Alpert Foundation Prize For their research in the development of statins which lower the level of cholesterol in the heart.

1991 - Fellow of the Royal Society, United Kingdom

1990 - Fellow of the American Association for the Advancement of Science (AAAS)

1988 - US President's National Medal of Science "For their historic discovery of the basic mechanisms controlling cholesterol metabolism, opening the way to a new pharmacologic approach to the treatment of cardiovascular disease, the leading cause of death and disability in the Western world.", Presented by President Reagan in a White House ceremony on July 15, 1988. Awarded jointly with Dr. Michael S. Brown, University of Texas Southwestern Medical Center.

1987 - Member of the National Academy of Medicine (NAM)

1985 - Nobel Prize for their discoveries concerning the regulation of cholesterol metabolism

1985 - Albert Lasker Award for Basic Medical Research, Lasker Foundation

1985 - William Allan Award, the American Society of Human Genetics

1984 - Louisa Gross Horwitz Prize, Columbia University

1981 - Fellow of the American Academy of Arts and Sciences

1981 - Canada Gairdner International Award

1980 - Member of the National Academy of Sciences

1979 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for their work in cholesterol biosynthesis.

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His primary areas of study are Biochemistry, Internal medicine, Endocrinology, LDL receptor and Cholesterol. Biochemistry is often connected to Cell biology in his work. His Internal medicine study frequently draws connections to adjacent fields such as Signal transduction.

Joseph L. Goldstein has researched LDL receptor in several fields, including Receptor, Endocytosis, Familial hypercholesterolemia and Low-density lipoprotein. His Cholesterol study combines topics from a wide range of disciplines, such as Reductase, Coenzyme A, HMG-CoA reductase, Hyperlipidemia and Arteriosclerosis. He has included themes like Molecular biology and Endoplasmic reticulum in his Sterol regulatory element-binding protein study.

His most cited work include:

  • A receptor-mediated pathway for cholesterol homeostasis. (4752 citations)
  • Regulation of the mevalonate pathway. (4483 citations)
  • SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver (3525 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Biochemistry, LDL receptor, Internal medicine, Cholesterol and Endocrinology. His Biochemistry study frequently links to adjacent areas such as Molecular biology. His LDL receptor study integrates concerns from other disciplines, such as Receptor, Cell surface receptor, Familial hypercholesterolemia and Low-density lipoprotein.

His studies in Low-density lipoprotein integrate themes in fields like Intermediate-density lipoprotein, Endocytosis and Low-density lipoprotein receptor gene family. His research links Hyperlipidemia with Internal medicine. His Cholesterol study combines topics in areas such as NPC1, Binding site and HMG-CoA reductase.

He most often published in these fields:

  • Biochemistry (46.83%)
  • LDL receptor (27.96%)
  • Internal medicine (27.44%)

What were the highlights of his more recent work (between 2006-2020)?

  • Biochemistry (46.83%)
  • Cholesterol (26.24%)
  • Endocrinology (26.24%)

In recent papers he was focusing on the following fields of study:

His main research concerns Biochemistry, Cholesterol, Endocrinology, Internal medicine and Ghrelin. His research related to Endoplasmic reticulum, Membrane protein, Sterol regulatory element-binding protein, Cholesterol binding and Cholesterol 7 alpha-hydroxylase might be considered part of Biochemistry. Joseph L. Goldstein combines subjects such as Biophysics, Cell biology, Binding site and NPC1 with his study of Cholesterol.

His Binding site research is multidisciplinary, incorporating perspectives in Endocytosis and Chinese hamster ovary cell. In his study, Molecular biology is strongly linked to Amino acid, which falls under the umbrella field of NPC1. His work on Receptor expands to the thematically related Endocrinology.

Between 2006 and 2020, his most popular works were:

  • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. (921 citations)
  • The LDL Receptor (780 citations)
  • Selective versus total insulin resistance: a pathogenic paradox. (639 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

Joseph L. Goldstein focuses on Cholesterol, Biochemistry, Internal medicine, Endocrinology and Endoplasmic reticulum. Joseph L. Goldstein interconnects Endocytosis and Binding site in the investigation of issues within Cholesterol. The concepts of his Endocrinology study are interwoven with issues in Signal transduction, Transgene and Fatty acid.

His work in Endoplasmic reticulum covers topics such as Membrane protein which are related to areas like Transport protein, COPII, Protein Sorting Signals, COP-Coated Vesicles and Plasma protein binding. His Sterol research includes elements of Transcription factor and HMG-CoA reductase. His LDL receptor research incorporates themes from Familial hypercholesterolemia, Receptor recycling and Receptor-mediated endocytosis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

A receptor-mediated pathway for cholesterol homeostasis.

Michael S. Brown;Joseph L. Goldstein.
Science (1986)

7345 Citations

Regulation of the mevalonate pathway.

Joseph L. Goldstein;Michael S. Brown.
Nature (1990)

6888 Citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Jay D. Horton;Joseph L. Goldstein;Michael S. Brown.
Journal of Clinical Investigation (2002)

5828 Citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

Michael S Brown;Joseph L Goldstein.
Cell (1997)

4768 Citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

Joseph L. Goldstein;Y. K. Ho;Sandip K. Basu;Michael S. Brown.
Proceedings of the National Academy of Sciences of the United States of America (1979)

3249 Citations

Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis

Michael S. Brown;Joseph L. Goldstein.
Annual Review of Biochemistry (1983)

3063 Citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

J. L. Goldstein;M. S. Brown.
Annual Review of Biochemistry (1977)

2838 Citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

Joseph L. Goldstein;Richard G. W. Anderson;Michael S. Brown.
Nature (1979)

2658 Citations

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

Joyce J. Repa;Guosheng Liang;Jiafu Ou;Yuriy Bashmakov.
Genes & Development (2000)

2229 Citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

Joseph L. Goldstein;Michael S. Brown;Richard G. W. Anderson;David W. Russell.
Annual Review of Cell Biology (1985)

2222 Citations

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