2026 Joseph L. Goldstein: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Best Scientists	242	61	56	42	39	598	219220
Biology and Biochemistry	243	8	8	6	6	576	222187

Research.com Recognitions

2026 - Research.com Biology and Biochemistry in United States Leader Award
2025 - Research.com Best Scientists Award
2025 - Research.com Biology and Biochemistry in United States Leader Award
2023 - Research.com Biology and Biochemistry in United States Leader Award
2022 - Research.com Biology and Biochemistry in United States Leader Award
2019 - Fellow, National Academy of Inventors
2007 - Member of the European Academy of Sciences
2003 - Albany Medical Center Prize in Medicine and Biomedical Research
2003 - Distinguished Scientist Award, American Heart Association
1999 - Warren Alpert Foundation Prize For their research in the development of statins which lower the level of cholesterol in the heart.
1991 - Fellow of the Royal Society, United Kingdom
1990 - Fellow of the American Association for the Advancement of Science (AAAS)
1988 - US President's National Medal of Science "For their historic discovery of the basic mechanisms controlling cholesterol metabolism, opening the way to a new pharmacologic approach to the treatment of cardiovascular disease, the leading cause of death and disability in the Western world.", Presented by President Reagan in a White House ceremony on July 15, 1988. Awarded jointly with Dr. Michael S. Brown, University of Texas Southwestern Medical Center.
1987 - Member of the National Academy of Medicine (NAM)
1985 - Nobel Prize for their discoveries concerning the regulation of cholesterol metabolism
1985 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
1985 - William Allan Award, the American Society of Human Genetics
1984 - Louisa Gross Horwitz Prize, Columbia University
1981 - Canada Gairdner International Award
1981 - Fellow of the American Academy of Arts and Sciences
1980 - Member of the National Academy of Sciences
1979 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for their work in cholesterol biosynthesis.
Member of the Association of American Physicians
Member of the Association of American Physicians
Member of the Association of American Physicians
Member of the Association of American Physicians

Overview

Joseph L. Goldstein is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research predominantly spans the fields of Biochemistry, Genetics and Molecular Biology and Medicine. Subfields of study include Molecular Biology, Surgery, Cell Biology, Endocrinology, Diabetes and Metabolism, and Endocrine and Autonomic Systems.

The scientist's main research topics encompass:

Cholesterol and Lipid Metabolism
Lipid Membrane Structure and Behavior
Sphingolipid Metabolism and Signaling
Cellular Transport and Secretion
Endoplasmic Reticulum Stress and Disease
Pancreatic Function and Diabetes
RNA and Protein Synthesis Mechanisms

Frequent publication venues include:

Proceedings of the National Academy of Sciences
Cell
Journal of Clinical Investigation
JAMA
Annals of Oncology

Frequent co-authors are:

Michael S. Brown
Michael Trinh
Gonçalo Vale
Jeffrey G. McDonald
Joachim Seemann

Key recent papers by Joseph L. Goldstein include:

"Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine" (2020, Proceedings of the National Academy of Sciences)
"Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol" (2022, Proceedings of the National Academy of Sciences)
"Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing" (2021, Cell)
"Unexpected role for IGF-1 in starvation: Maintenance of blood glucose" (2022, Proceedings of the National Academy of Sciences)
"The Spanish 1918 Flu and the COVID-19 Disease: The Art of Remembering and Foreshadowing Pandemics" (2020, Cell)

Joseph L. Goldstein has been the recipient of multiple awards throughout their career, including:

Fellow, National Academy of Inventors (2019)
Member of the European Academy of Sciences (2007)
Distinguished Scientist Award, American Heart Association (2003)
Albany Medical Center Prize in Medicine and Biomedical Research (2003)
Warren Alpert Foundation Prize (1999) for research in the development of statins which lower the level of cholesterol in the heart
Fellow of the Royal Society, United Kingdom (1991)
Fellow of the American Association for the Advancement of Science (AAAS) (1990)
US President's National Medal of Science (1988) awarded jointly with Michael S. Brown for discoveries controlling cholesterol metabolism
Member of the National Academy of Medicine (NAM) (1987)
Nobel Prize (1985) for discoveries concerning the regulation of cholesterol metabolism
William Allan Award, American Society of Human Genetics (1985)
Albert Lasker Award for Basic Medical Research (1985)
Louisa Gross Horwitz Prize, Columbia University (1984)
Canada Gairdner International Award (1981)
Fellow of the American Academy of Arts and Sciences (1981)
Member of the National Academy of Sciences (1980)
Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences (1979) for work in cholesterol biosynthesis
Member of the Association of American Physicians

Best Publications

Regulation of the mevalonate pathway.

Joseph L. Goldstein;Michael S. Brown

11247
Citations
A receptor-mediated pathway for cholesterol homeostasis.

Michael S. Brown;Joseph L. Goldstein

10048
Citations
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Jay D. Horton;Joseph L. Goldstein;Michael S. Brown

5448
Citations
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

Michael S Brown;Joseph L Goldstein

5320
Citations
Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis

Michael S. Brown;Joseph L. Goldstein

3621
Citations
Binding Site on Macrophages that Mediates Uptake and Degradation of Acetylated Low Density Lipoprotein, Producing Massive Cholesterol Deposition

Joseph L. Goldstein;Y. K. Ho;Sandip K. Basu;Michael S. Brown

3509
Citations
The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

J. L. Goldstein;M. S. Brown

3293
Citations
Coated pits, coated vesicles, and receptor-mediated endocytosis

Joseph L. Goldstein;Richard G. W. Anderson;Michael S. Brown

2956
Citations
Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

Joseph L. Goldstein;Sandip K. Basu;Michael S. Brown

2356
Citations
Protein Sensors for Membrane Sterols

Joseph L. Goldstein;Russell A. DeBose-Boyd;Michael S. Brown

2293
Citations
Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

Joseph L. Goldstein;Michael S. Brown;Richard G. W. Anderson;David W. Russell

2245
Citations
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

Jin Ye;Robert B Rawson;Ryutaro Komuro;Xi Chen

2142
Citations
Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIA

Joseph L. Goldstein;Helmut G. Schrott;William R. Hazzard;Edwin L. Bierman

2117
Citations
Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts COMPARISON OF CELLS FROM A NORMAL SUBJECT AND FROM A PATIENT WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

Joseph L. Goldstein;Michael S. Brown

2071
Citations
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

Shun Ishibashi;Michael S Brown;Joseph L Goldstein;Robert D. Gerard

2005
Citations
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

Joyce J. Repa;Guosheng Liang;Jiafu Ou;Yuriy Bashmakov

2000
Citations
The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

Tokuo Yamamoto;C. Geoffrey Davis;Michael S. Brown;Wolfgang J. Schneider

1974
Citations
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

Michael S. Brown;Joseph L. Goldstein

1954
Citations
Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth

Michael S. Brown;Joseph L. Goldstein

1670
Citations
Regulated Intramembrane Proteolysis: A Control Mechanism Conserved from Bacteria to Humans

Michael S. Brown;Jin Ye;Robert B. Rawson;Joseph L. Goldstein

1664
Citations