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Molecular Biology

D-Index
78
Citations
50358
World Ranking
1054
National Ranking
551

Overview

Jay D. Horton is affiliated with The University of Texas Southwestern Medical Center in the United States. The primary fields of research include Medicine and Biochemistry, Genetics and Molecular Biology, with subfields covering Surgery, Epidemiology, Physiology, Molecular Biology, and Biochemistry.

The scientist's research topics reflect significant work on adipose tissue and metabolism, liver disease diagnosis and treatment, lipid metabolism and biosynthesis, lipoproteins and cardiovascular health, bariatric surgery and outcomes, cancer related to lipids and metabolism, and pancreatic function and diabetes.

Jay D. Horton has contributed to multiple publications in notable scientific venues. Frequent publication outlets include:

  • iScience
  • Cell Metabolism
  • Circulation
  • Journal of Lipid Research
  • European Heart Journal

Some recent papers authored or coauthored by Jay D. Horton include:

  • Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel, 2020, European Heart Journal
  • DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER, 2024, Cell Metabolism
  • Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability, 2024, Cell Metabolism
  • The impact of endotrophin on the progression of chronic liver disease, 2020, Experimental & Molecular Medicine
  • Measurement of lipogenic flux by deuterium resolved mass spectrometry, 2021, Nature Communications

Frequent coauthors in Jay D. Horton's research collaborations include:

  • Gonçalo Vale
  • Jeffrey G. McDonald
  • Chai-Wan Kim
  • Anil K. Agarwal
  • Abhimanyu Garg

Best Publications

  • Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

    Brian A Ference;Henry N Ginsberg;Ian T. Graham;Kausik K Ray

  • Human fatty liver disease: old questions and new insights.

    Jonathan C. Cohen;Jay D. Horton;Helen H. Hobbs

  • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

    Jay D. Horton;Nila A. Shah;Janet A. Warrington;Norma N. Anderson

  • Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

    Jan Borén;M. John Chapman;M. John Chapman;Ronald M. Krauss;Chris J. Packard

  • Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation

    Da Wei Zhang;Thomas A. Lagace;Rita Garuti;Zhenze Zhao

  • Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

    Hitoshi Shimano;Jay D Horton;Iichiro Shimomura;Robert E Hammer

  • Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

    Iichiro Shimomura;Yuriy Bashmakov;Shinji Ikemoto;Jay D. Horton

  • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

    Iichiro Shimomura;Hitoshi Shimano;Jay D. Horton;Joseph L. Goldstein

  • Molecular biology of PCSK9: its role in LDL metabolism

    Jay D. Horton;Jonathan C. Cohen;Helen H. Hobbs

  • Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

    Jay D. Horton;Iichiro Shimomura;Michael S. Brown;Robert E. Hammer

  • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

    Maria Frank-Kamenetsky;Aldo Grefhorst;Norma N. Anderson;Timothy S. Racie

  • Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice

    Unknown

  • Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

    Guosheng Liang;Jian Yang;Jay D Horton;Robert E Hammer

  • Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

    Unknown

  • Molecular Characterization of Loss-of-Function Mutations in PCSK9 and Identification of a Compound Heterozygote

    Zhenze Zhao;Yetsa Tuakli-Wosornu;Thomas A. Lagace;Lisa Kinch

  • Acetate dependence of tumors.

    Sarah A Comerford;Zhiguang Huang;Xinlin Du;Yun Wang

  • Molecular basis for LDL receptor recognition by PCSK9

    Hyock Joo Kwon;Thomas A. Lagace;Markey C. McNutt;Jay D. Horton

  • Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

    Hitoshi Shimano;Iichiro Shimomura;Robert E. Hammer;Joachim Herz

  • Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver

    Unknown

  • Identification of a Mammalian Long Chain Fatty Acyl Elongase Regulated by Sterol Regulatory Element-binding Proteins

    Young Ah Moon;Nila A. Shah;Suchismita Mohapatra;Janet A. Warrington

Frequent Co-Authors

Michael S. Brown
Michael S. Brown The University of Texas Southwestern Medical Center
Joseph L. Goldstein
Joseph L. Goldstein The University of Texas Southwestern Medical Center
Robert E. Hammer
Robert E. Hammer The University of Texas Southwestern Medical Center
Helen H. Hobbs
Helen H. Hobbs The University of Texas Southwestern Medical Center
Philipp E. Scherer
Philipp E. Scherer The University of Texas Southwestern Medical Center
Jonathan Cohen
Jonathan Cohen The University of Texas Southwestern Medical Center
Shawn C. Burgess
Shawn C. Burgess The University of Texas Southwestern Medical Center
Abhimanyu Garg
Abhimanyu Garg The University of Texas Southwestern Medical Center
Jeffrey G. McDonald
Jeffrey G. McDonald The University of Texas Southwestern Medical Center
Martin Maier
Martin Maier Alnylam Pharmaceuticals (United States)

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