Helen H. Hobbs

Research.com Recognitions

• 2025 - Research.com Best Female Scientists Award
• 2016 - Breakthrough Prize in Life Sciences for the discovery of human genetic variants that alter the levels and distribution of cholesterol and other lipids, inspiring new approaches to the prevention of cardiovascular and liver disease.
• 2015 - Fellow of the American Association for the Advancement of Science (AAAS)
• 2013 - Robert J. and Claire Pasarow Foundation Medical Research Award
• 2007 - Member of the National Academy of Sciences
• 2007 - Distinguished Scientist Award, American Heart Association
• 2006 - Fellow of the American Academy of Arts and Sciences
• 2004 - Member of the National Academy of Medicine (NAM)
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians
• Member of the Association of American Physicians

Overview

Best Publications

• Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity

  Jeffrey D. Browning;Lidia S. Szczepaniak;Robert Dobbins;Pamela Nuremberg

  4582
  Citations

• Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease

  Jonathan C. Cohen;Eric Boerwinkle;Thomas H. Mosley;Helen H. Hobbs

  4340
  Citations

• Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

  Susan Acton;Attilio Rigotti;Katherine T. Landschulz;Shangzhe Xu

  3499
  Citations

• Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

  Stefano Romeo;Julia Kozlitina;Julia Kozlitina;Chao Xing;Alexander Pertsemlidis

  3361
  Citations

• Common allele on chromosome 9 associated with coronary heart disease

  Jonathan C. Cohen;Helen H. Hobba

  2418
  Citations

• Human fatty liver disease: old questions and new insights.

  Jonathan C. Cohen;Jay D. Horton;Helen H. Hobbs

  2367
  Citations

• Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population

  Lidia S. Szczepaniak;Pamela Nurenberg;David Leonard;Jeffrey D Browning

  2192
  Citations

• Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

  Knut E. Berge;Hui Tian;Gregory A. Graf;Liqing Yu

  1985
  Citations

• Molecular genetics of the LDL receptor gene in familial hypercholesterolemia

  Helen H. Hobbs;Michael S. Brown;Joseph L. Goldstein

  1606
  Citations

• Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

  Jonathan Cohen;Alexander Pertsemlidis;Ingrid K Kotowski;Randall Graham

  1560
  Citations

• Apolipoprotein(a) gene accounts for greater than 90 % of the variation in plasma lipoprotein(a) concentrations

  Eric Boerwinkle;Carla C. Leffert;Jingping Lin;Carolin Lackner

  1361
  Citations

• Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

  Jonathan C. Cohen;Robert S. Kiss;Alexander Pertsemlidis;Yves L. Marcel

  1267
  Citations

• Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β

  Joyce J. Repa;Knut E. Berge;Chris Pomajzl;James A. Richardson

  1211
  Citations

• Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.

  Julia Kozlitina;Eriks Smagris;Stefan Stender;Børge G Nordestgaard

  1161
  Citations

• Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation

  Da Wei Zhang;Thomas A. Lagace;Rita Garuti;Zhenze Zhao

  1126
  Citations

• Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

  Liqing Yu;Robert E. Hammer;Jia Li-Hawkins;Klaus von Bergmann

  1039
  Citations

• The LDL Receptor Locus in Familial Hypercholesterolemia: Mutational Analysis of a Membrane Protein

  Helen H. Hobbs;David W. Russell;Michael S. Brown;Joseph L. Goldstein

  979
  Citations

• High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase

  Ivan S. Yuhanna;Yan Zhu;Blair E. Cox;Lisa D. Hahner

  905
  Citations

• Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

  Liqing Yu;Jia Li-Hawkins;Robert E. Hammer;Knut E. Berge

  882
  Citations

• A common allele on chromosome 9 associated with coronary heart disease

  Ruth McPherson;Alexander Pertsemlidis;Nihan Kavaslar;Alexandre Stewart

  96
  Citations