World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
109
Citations
56567
World Ranking
544
National Ranking
274

Molecular Biology

D-Index
109
Citations
56567
World Ranking
384
National Ranking
221

Overview

Nick V. Grishin is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research has primarily focused on the fields of Biochemistry, Genetics and Molecular Biology, as well as Agricultural and Biological Sciences.

Their subfields of study include Molecular Biology, Genetics, Ecology, Evolution, Behavior and Systematics, Plant Science, and Ecological Modeling. Main research topics covered by their work include Lepidoptera: Biology and Taxonomy, Plant and animal studies, RNA and protein synthesis mechanisms, Protein Structure and Dynamics, Species Distribution and Climate Change, Genetic diversity and population structure, and the application of Machine Learning in Bioinformatics.

Nick V. Grishin's recent papers demonstrate engagement with structural biology, protein function, and computational biology. Selected publications include:

  • Structure, lipid scrambling activity and role in autophagosome formation of ATG9A (2020, Nature Structural & Molecular Biology)
  • The Pfam protein families database: embracing AI/ML (2024, Nucleic Acids Research)
  • A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis (2020, Nature Chemical Biology)
  • A Fifth of the Protein World: Rossmann-like Proteins as an Evolutionarily Successful Structural unit (2020, Journal of Molecular Biology)
  • Topology evaluation of models for difficult targets in the 14th round of the critical assessment of protein structure prediction (CASP14) (2021, Proteins Structure Function and Bioinformatics)

These works reveal a focus on protein structural dynamics, evolutionary biology, and computational modeling relevant to protein families and disease mechanisms.

Frequent collaborators in Nick V. Grishin's research include Qian Cong, R. Dustin Schaeffer, Lisa N. Kinch, Kirill E. Medvedev, and Jing Zhang. These partnerships have contributed to a substantial output in their shared fields of inquiry.

Their research has been published recurrently in prominent venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PubMed
  • Proteins Structure Function and Bioinformatics
  • Zenodo (CERN European Organization for Nuclear Research)
  • Journal of Molecular Biology

Nick V. Grishin's scholarly efforts span diverse topics in molecular biology and bioinformatics. The combination of experimental and computational approaches is evident in their publication record and research collaborations.

Best Publications

  • Accurate prediction of protein structures and interactions using a three-track neural network

    Minkyung Baek;Frank DiMaio;Ivan Anishchenko;Justas Dauparas

  • Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

    Masato Kato;Tina W. Han;Shanhai Xie;Kevin Shi

  • Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

    Knut E. Berge;Hui Tian;Gregory A. Graf;Liqing Yu

  • Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey

    Sung Chan Kim;Robert Sprung;Yue Chen;Yingda Xu

  • A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

    Kira S Makarova;Nick V Grishin;Svetlana A Shabalina;Yuri I Wolf

  • Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

    Siqi Liu;Xin Cai;Jiaxi Wu;Qian Cong

  • PROMALS3D: a tool for multiple protein sequence and structure alignments.

    Jimin Pei;Bong Hyun Kim;Nick V. Grishin

  • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.

    Jing Yang;Michael S. Brown;Guosheng Liang;Nick V. Grishin

  • Structural classification of zinc fingers: survey and summary.

    S. Sri Krishna;Indraneel Majumdar;Nick V. Grishin

  • BAP1 loss defines a new class of renal cell carcinoma

    Samuel Peña-Llopis;Silvia Vega-Rubín-De-Celis;Silvia Vega-Rubín-De-Celis;Arnold Liao;Nan Leng

  • Identification of a candidate therapeutic autophagy-inducing peptide

    Sanae Shoji-Kawata;Rhea Sumpter;Matthew J Leveno;Grant R. Campbell;Grant R. Campbell

  • Molecular Characterization of Loss-of-Function Mutations in PCSK9 and Identification of a Compound Heterozygote

    Zhenze Zhao;Yetsa Tuakli-Wosornu;Thomas A. Lagace;Lisa Kinch

  • Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein.

    Christine Kim Garcia;Kenneth Wilund;Marcello Arca;Giovanni Zuliani

  • A sequence variation (I148M) in PNPlA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

    Shaoqing He;Christopher McPhaul;John Zhong Li;Rita Garuti

  • The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology

    Kimberly M. Szymanski;Derk Binns;René Bartz;Nick V. Grishin

  • EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

    Yongjie Wei;Zhongju Zou;Nils Becker;Matthew Anderson

  • Structure prediction for CASP8 with all‐atom refinement using Rosetta

    Srivatsan Raman;Robert Vernon;James Thompson;Michael Tyka

  • AL2CO: calculation of positional conservation in a protein sequence alignment

    Jimin Pei;Nick V. Grishin

  • Fold change in evolution of protein structures.

    Nick V. Grishin

  • Genetic Defects in Surfactant Protein A2 Are Associated with Pulmonary Fibrosis and Lung Cancer

    Yongyu Wang;Phillip J. Kuan;Chao Xing;Jennifer T. Cronkhite

Frequent Co-Authors

Lisa N. Kinch
Lisa N. Kinch The University of Texas Southwestern Medical Center
Ruslan I. Sadreyev
Ruslan I. Sadreyev Harvard University
Kim Orth
Kim Orth The University of Texas Southwestern Medical Center
Sanjay Krishna
Sanjay Krishna The Ohio State University
Andrei L. Osterman
Andrei L. Osterman Discovery Institute
Winnie Hallwachs
Winnie Hallwachs University of Pennsylvania
Daniel H. Janzen
Daniel H. Janzen University of Pennsylvania
Eugene V. Koonin
Eugene V. Koonin National Institutes of Health
Leszek Rychlewski
Leszek Rychlewski BioInfoBank Institute
Kira S. Makarova
Kira S. Makarova National Institutes of Health

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