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Biology and Biochemistry

D-Index
64
Citations
15155
World Ranking
9632
National Ranking
4254

Overview

Kounosuke Watabe is affiliated with Wake Forest University in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology. The primary scientific focus includes molecular biology, oncology, pulmonary and respiratory medicine, cancer research, and genetics. Watabe's work often intersects with several important topics such as brain metastases and treatment, glioma diagnosis and treatment, extracellular vesicles in disease, lung cancer research studies, cancer, stress, anesthesia, and immune response, nanoplatforms for cancer theranostics, and cancer, hypoxia, and metabolism.

The scientist's publication record features papers in notable venues, with frequent contributions to journals such as Cancer Research, Oncogene, Nature Communications, Breast Cancer Research, and Frontiers in Oncology. A selection of recent papers illustrates the thematic range and depth of their work:

  • Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis (2020, Molecular Cell)
  • RETRACTED ARTICLE: Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung (2021, Nature Communications)
  • Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer (2021, Nature Communications)
  • The Confounders of Cancer Immunotherapy: Roles of Lifestyle, Metabolic Disorders and Sociological Factors (2020, Cancers)
  • Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function (2020, The Journal of Experimental Medicine)

Frequent collaborators in these scientific endeavors include Shih-Ying Wu, Abhishek Tyagi, Kerui Wu, Ravindra Pramod Deshpande, and Sambad Sharma. These coauthors have worked extensively with Watabe, demonstrating a substantial joint research output over time.

The scientist's contributions cover a broad range of cancer biology and therapy, with particular attention to mechanisms underlying metastasis, immune response in cancer contexts, and molecular signaling pathways. Their engagement with extracellular vesicles and nanoplatforms further emphasizes involvement in innovative approaches to cancer treatment and diagnosis.

Best Publications

  • p53 represses c-Myc through induction of the tumor suppressor miR-145

    Mohit Sachdeva;Shoumin Zhu;Fangting Wu;Hailong Wu

  • Cancer associated fibroblasts (CAFs) in tumor microenvironment.

    Fei Xing;Jamila Saidou;Kounosuke Watabe

  • Negative regulation of lncRNA GAS5 by miR-21

    Zhang Z;Zhu Z;Watabe K;Zhang X

  • Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

    Eiji Furuta;Sudha K. Pai;Rui Zhan;Sucharita Bandyopadhyay

  • Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1).

    Huang J;Zhou N;Watabe K;Lu Z

  • Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

    Aya Kobayashi;Hiroshi Okuda;Fei Xing;Puspa R. Pandey

  • Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer

    Ramesh Singh;Radhika Pochampally;Kounosuke Watabe;Zhaohui Lu

  • The Drg-1 Gene Suppresses Tumor Metastasis in Prostate Cancer

    Sucharita Bandyopadhyay;Sudha K. Pai;Steven C. Gross;Shigeru Hirota

  • Metabolic genes in cancer: their roles in tumor progression and clinical implications.

    Eiji Furuta;Hiroshi Okuda;Aya Kobayashi;Kounosuke Watabe

  • The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage

    Ali Zhang;Nanjiang Zhou;Jianguo Huang;Qian Liu

  • Mechanisms regulating glioma invasion

    Ivy Paw;Richard C. Carpenter;Kounosuke Watabe;Waldemar Debinski

  • Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites

    Krishna C. Vallabhaneni;Patrice Penfornis;Santosh Dhule;Francois Guillonneau

  • miR-7 Suppresses Brain Metastasis of Breast Cancer Stem-Like Cells By Modulating KLF4

    Hiroshi Okuda;Fei Xing;Puspa R. Pandey;Sambad Sharma

  • Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression

    Sucharita Bandyopadhyay;Rui Zhan;Asok Chaudhuri;Misako Watabe

  • Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis

    Fei Xing;Yin Liu;Shih-Ying Wu;Kerui Wu

  • Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

    Fei Xing;Hiroshi Okuda;Misako Watabe;Aya Kobayashi

  • Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression.

    Sucharita Bandyopadhyay;Sudha K Pai;Shigeru Hirota;Sadahiro Hosobe

  • Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

    Ingrid Espinoza;Radhika Pochampally;Fei Xing;Kounosuke Watabe

  • Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase.

    Puspa R. Pandey;Hiroshi Okuda;Misako Watabe;Sudha K. Pai

  • Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem–Like Cells with Macrophages and Stromal Cells

    Hiroshi Okuda;Aya Kobayashi;Bo Xia;Misako Watabe

Frequent Co-Authors

Yin-Yuan Mo
Yin-Yuan Mo University of Mississippi Medical Center
Lance D. Miller
Lance D. Miller Wake Forest University
Ralph B. D'Agostino
Ralph B. D'Agostino Wake Forest University
Xiaobo Zhou
Xiaobo Zhou The University of Texas Health Science Center at Houston
Hui Kuan Lin
Hui Kuan Lin Wake Forest University
Ge Wang
Ge Wang Rensselaer Polytechnic Institute
Edward A. Levine
Edward A. Levine Wake Forest University
Subash C. Gupta
Subash C. Gupta Banaras Hindu University
Gregory A. Hawkins
Gregory A. Hawkins Wake Forest University
Fuu Jen Tsai
Fuu Jen Tsai China Medical University

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