Kira S. Makarova spends much of her time researching Genetics, Genome, CRISPR, Computational biology and Gene. Her study in Cas9, Protospacer adjacent motif, Horizontal gene transfer, Genome editing and Phylogenetics is done as part of Genetics. Her Genome research includes themes of Deinococcus deserti, Sequence alignment and Protein family.
Kira S. Makarova interconnects RNA, Acquired immune system and Effector in the investigation of issues within CRISPR. The study incorporates disciplines such as RNA interference, Locus, Guide RNA and Mobile genetic elements in addition to Computational biology. In her research, CRISPR Spacers is intimately related to CRISPR Loci, which falls under the overarching field of Trans-activating crRNA.
Her primary areas of investigation include Genetics, Genome, Gene, CRISPR and Computational biology. Horizontal gene transfer, Archaea, Phylogenetics, DNA and Phylogenetic tree are subfields of Genetics in which her conducts study. Her Genome research is multidisciplinary, relying on both Evolutionary biology, Deinococcus radiodurans and Protein family.
Her CRISPR research integrates issues from RNA, Plasmid, Mobile genetic elements and Effector. Her research in Computational biology intersects with topics in Acquired immune system, Genome editing, Cas9, Guide RNA and Locus. Kira S. Makarova has included themes like CRISPR Loci and Protospacer adjacent motif in her Trans-activating crRNA study.
Kira S. Makarova spends much of her time researching CRISPR, Genome, Computational biology, Genetics and Gene. Her studies in CRISPR integrate themes in fields like RNA, DNA, Mobile genetic elements, Transposable element and Effector. Her RNA study incorporates themes from Trans-activating crRNA and Nucleic acid.
Her Genome research is multidisciplinary, incorporating perspectives in Evolutionary biology, Archaea and Locus. The Computational biology study combines topics in areas such as Acquired immune system, Comparative genomics, Cas9, Genome editing and Nuclease. Kira S. Makarova conducts interdisciplinary study in the fields of Genetics and Group II intron through her research.
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Small CRISPR RNAs guide antiviral defense in prokaryotes
Stan J. J. Brouns;Matthijs M. Jore;Magnus Lundgren;Edze R. Westra.
Evolution and classification of the CRISPR-Cas systems
Kira S. Makarova;Daniel H. Haft;Rodolphe Barrangou;Stan J. J. Brouns.
Nature Reviews Microbiology (2011)
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.
Bernd Zetsche;Jonathan S. Gootenberg;Omar O. Abudayyeh;Ian M. Slaymaker.
In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran;Le Cong;Winston X. Yan;David A. Scott.
An updated evolutionary classification of CRISPR–Cas systems
Kira S. Makarova;Yuri I. Wolf;Omer S. Alkhnbashi;Fabrizio Costa.
Nature Reviews Microbiology (2015)
Comparative genomics of the lactic acid bacteria
K. Makarova;A. Slesarev;Y. Wolf;A. Sorokin.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Crystal Structure of Cas9 in Complex With Guide RNA and Target DNA
Takashi Yamano;Hiroshi Nishimasu;Hiroshi Nishimasu;Bernd Zetsche;Hisato Hirano.
Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1.
O. White;J. A. Eisen;J. F. Heidelberg;E. K. Hickey.
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action
Kira S Makarova;Nick V Grishin;Svetlana A Shabalina;Yuri I Wolf.
Biology Direct (2006)
Horizontal gene transfer in prokaryotes: quantification and classification.
Eugene V. Koonin;Kira S. Makarova;L. Aravind.
Annual Review of Microbiology (2001)
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