World's Best Scientists 2026 revealed!
Luciano A. Marraffini

Luciano A. Marraffini

D-Index & Metrics

Genetics

D-Index
58
Citations
54192
World Ranking
3274
National Ranking
1425

Research.com Recognitions

  • 2019 - Member of the National Academy of Sciences
  • 2017 - National Institutes of Health Director's Pioneer Award
  • 2017 - Albany Medical Center Prize in Medicine and Biomedical Research

Overview

Luciano A. Marraffini is affiliated with Rockefeller University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with notable contributions to medicine. The main areas of study include molecular biology, epidemiology, ecology, genetics, and insect science. Marraffini's work prominently addresses topics such as CRISPR and genetic engineering, RNA and protein synthesis mechanisms, cytomegalovirus and herpesvirus research, bacteriophages and microbial interactions, insect symbiosis and bacterial influences, bacterial genetics and biotechnology, and viral infections and immunology research.

The scientist has published extensively in several venues, including bioRxiv (Cold Spring Harbor Laboratory), Nature, Molecular Cell, Nucleic Acids Research, and Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature. Among their recent papers are:

  • Molecular Mechanisms of CRISPR-Cas Immunity in Bacteria, 2020, Annual Review of Genetics
  • The Card1 nuclease provides defence during type III CRISPR immunity, 2021, Nature
  • A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity, 2020, Science
  • Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6, 2020, Nature Communications
  • Cleavage of viral DNA by restriction endonucleases stimulates the type II CRISPR-Cas immune response, 2022, Molecular Cell

Frequent collaborators in their research include Jakob T. Rostøl, Dinshaw J. Patel, Dalton V. Banh, Sean F. Brady, and Naama Aviram.

Luciano A. Marraffini has been recognized with several scientific distinctions. These include membership in the National Academy of Sciences (2019), the National Institutes of Health Director's Pioneer Award (2017), and the Albany Medical Center Prize in Medicine and Biomedical Research (2017).

Best Publications

  • Multiplex Genome Engineering Using CRISPR/Cas Systems

    Le Cong;Le Cong;F. Ann Ran;F. Ann Ran;David M. Cox;David M. Cox;Shuailiang Lin;Shuailiang Lin

  • DNA targeting specificity of RNA-guided Cas9 nucleases

    Patrick D Hsu;David Arthur Scott;David Arthur Scott;Joshua A Weinstein;Joshua A Weinstein;F. Ann Ran;F. Ann Ran;F. Ann Ran

  • RNA-guided editing of bacterial genomes using CRISPR-Cas systems

    Wenyan Jiang;David Bikard;David R Cox;David R Cox;Feng Zhang;Feng Zhang

  • CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

    Luciano A. Marraffini;Erik J. Sontheimer

  • Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

    David Bikard;Wenyan Jiang;Poulami Samai;Ann Hochschild

  • CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

    Luciano A. Marraffini;Erik J. Sontheimer

  • Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

    David Bikard;Chad W Euler;Wenyan Jiang;Philip M Nussenzweig

  • Sortases and the Art of Anchoring Proteins to the Envelopes of Gram-Positive Bacteria

    Luciano A. Marraffini;Andrea C. DeDent;Olaf Schneewind

  • CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity

    Rodolphe Barrangou;Luciano A. Marraffini

  • Self versus non-self discrimination during CRISPR RNA-directed immunity

    Luciano A. Marraffini;Erik J. Sontheimer

  • CRISPR-Cas immunity in prokaryotes

    Luciano A. Marraffini

  • Cas9 specifies functional viral targets during CRISPR-Cas adaptation

    Robert Heler;Poulami Samai;Joshua W. Modell;Catherine Weiner

  • Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity

    Poulami Samai;Nora Pyenson;Wenyan Jiang;Gregory W. Goldberg

  • CRISPR Interference Can Prevent Natural Transformation and Virulence Acquisition during In Vivo Bacterial Infection

    David Bikard;Asma Hatoum-Aslan;Daniel Mucida;Luciano A. Marraffini

  • Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers.

    Ole Niewoehner;Carmela Garcia-Doval;Jakob T. Rostøl;Christian Berk

  • CRISPR-Cas component systems, methods and compositions for sequence manipulation

    Feng Zhang;David Olivier Bikard;Le Cong;David Benjamin Turitz Cox

  • Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site

    Asma Hatoum-Aslan;Inbal Maniv;Luciano A. Marraffini

  • TARGET DNA INTERFERENCE WITH crRNA

    Erik J. Sontheimer;Luciano A. Marraffini

  • Protein sorting to the cell wall envelope of Gram-positive bacteria.

    Hung Ton-That;Luciano A. Marraffini;Olaf Schneewind

  • Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

    Gregory W. Goldberg;Wenyan Jiang;David Bikard;Luciano A. Marraffini

Frequent Co-Authors

Olaf Schneewind
Olaf Schneewind University of Chicago
Neville E. Sanjana
Neville E. Sanjana New York University
Erik J. Sontheimer
Erik J. Sontheimer University of Massachusetts Chan Medical School
Dinshaw J. Patel
Dinshaw J. Patel Memorial Sloan Kettering Cancer Center
Martin Jinek
Martin Jinek University of Zurich
Hung Ton-That
Hung Ton-That University of California, Los Angeles
David R. Liu
David R. Liu Broad Institute
Jennifer A. Doudna
Jennifer A. Doudna University of California, Berkeley
Emmanuelle Charpentier
Emmanuelle Charpentier Max Planck Institute for Infection Biology

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring genetics can open doors to a broad range of careers beyond the lab. Many students interested in genetics also look into medical and healthcare fields that offer flexible and fast-track online study options.

For those leaning toward nursing, there are now online rn to bsn programs designed to allow registered nurses to earn their BSN degree without traditional clinical requirements. This option can make advancing your qualifications more accessible while balancing work.

If you're looking to reach the highest levels in nursing as quickly as possible, the quickest dnp program offers a pathway to a Doctor of Nursing Practice in the shortest time, helping you achieve leadership roles faster.

Alternatively, those seeking entry-level healthcare positions can consider an accelerated medical assistant program, some of which can be completed in as few as six weeks. This can be an excellent starting point for a career in medical settings.

For students focused on affordability, there are also options for the cheapest dnp programs, ensuring that career advancement doesn't have to come at a high financial cost.

These online degrees and programs provide diverse ways to build a rewarding career in genetics and healthcare—each with unique benefits in speed, flexibility, and cost.

Best Scientists Citing Luciano A. Marraffini

Trending Scientists

Recently Published Articles