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Biology and Biochemistry

D-Index
47
Citations
11532
World Ranking
18595
National Ranking
7601

Overview

Hung Ton-That is a researcher affiliated with the University of California, Los Angeles in the United States. Their work spans multiple areas within biochemistry, genetics, molecular biology, and medicine, contributing to a broad spectrum of scientific knowledge primarily focused on molecular and microbial biology.

The scientist's research outputs cover significant subfields such as molecular biology, public health, environmental and occupational health, periodontics, infectious diseases, and biotechnology. Their principal topics of study include biochemical and structural characterization, streptococcal infections and treatments, oral microbiology and periodontitis research, enzyme production and characterization, as well as aspects of diphtheria, Corynebacterium, tetanus, toxin mechanisms, immunotoxins, and infectious diseases related to otolaryngology.

Hung Ton-That has published extensively, with frequent contributions appearing in notable journals and venues. The most common publication venues include:

  • mBio
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Current Protocols in Microbiology
  • Methods in Molecular Biology

They have coauthored many papers with colleagues Chungyu Chang, Asis Das, Chenggang Wu, Aadil H. Bhat, and Andreas Tauch, indicating a collaborative approach within their research community.

Some of Hung Ton-That's recent research publications include:

  • "Genetic and molecular determinants of polymicrobial interactions in Fusobacterium nucleatum", 2021, Proceedings of the National Academy of Sciences
  • "Biological biomarkers of oral cancer", 2023, Periodontology 2000
  • "Anchoring surface proteins to the bacterial cell wall by sortase enzymes: how it started and what we know now", 2021, Current Opinion in Microbiology
  • "Genetic Manipulation and Virulence Assessment of Fusobacterium nucleatum", 2020, Current Protocols in Microbiology
  • "New Paradigms of Pilus Assembly Mechanisms in Gram-Positive Actinobacteria", 2020, Trends in Microbiology

Best Publications

  • Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall

    Sarkis K. Mazmanian;Gwen Liu;Hung Ton-That;Olaf Schneewind

  • Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif

    Hung Ton-That;Gwen Liu;Sarkis K. Mazmanian;Kym F. Faull

  • An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis

    Sarkis K. Mazmanian;Hung Ton-That;Kenneth Su;Olaf Schneewind

  • Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH(2)-Gly(3) substrates.

    Hung Ton-That;Sarkis K. Mazmanian;Kym F. Faull;Olaf Schneewind

  • Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus.

    Sarkis K. Mazmanian;Hung Ton-That;Olaf Schneewind

  • Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development

    Anjali Mandlik;Arlene Swierczynski;Asis Das;Hung Ton-That

  • Assembly of pili on the surface of Corynebacterium diphtheriae.

    Hung Ton-That;Olaf Schneewind

  • Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus

    Udayar Ilangovan;Hung Ton-That;Junji Iwahara;Olaf Schneewind

  • Protein sorting to the cell wall envelope of Gram-positive bacteria.

    Hung Ton-That;Luciano A. Marraffini;Olaf Schneewind

  • CRYSTAL STRUCTURES OF STAPHYLOCOCCUS AUREUS SORTASE A AND ITS SUBSTRATE COMPLEX

    Yinong Zong;Todd W. Bice;Hung Ton-That;Olaf Schneewind

  • Assembly of pili in Gram-positive bacteria

    Hung Ton-That;Olaf Schneewind

  • Anchoring of surface proteins to the cell wall of Staphylococcus aureus: III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring

    Adrienne M. Perry;Hung Ton-That;Sarkis K. Mazmanian;Olaf Schneewind

  • Multiple Enzymatic Activities of the Murein Hydrolase from Staphylococcal Phage φ11: IDENTIFICATION OF A d-ALANYL-GLYCINE ENDOPEPTIDASE ACTIVITY *

    William Wiley Navarre;Hung Ton-That;Kym F. Faull;Olaf Schneewind

  • Sortases and pilin elements involved in pilus assembly of Corynebacterium diphtheriae.

    Hung Ton-That;Luciano A. Marraffini;Olaf Schneewind

  • Anchoring of surface proteins to the cell wall of Staphylococcus aureus: Cysteine 184 and histidine 120 of sortase form a thiolate-imidazolium ion pair for catalysis

    Hung Ton-That;Sarkis K. Mazmanian;Sarkis K. Mazmanian;Lefa Alksne;Olaf Schneewind

  • Corynebacterium diphtheriae employs specific minor pilins to target human pharyngeal epithelial cells

    Anjali Mandlik;Arlene Swierczynski;Asis Das;Hung Ton-That

  • Anchor structure of staphylococcal surface proteins. IV. Inhibitors of the cell wall sorting reaction.

    Hung Ton-That;Olaf Schneewind

  • Anchor Structure of Staphylococcal Surface Proteins A BRANCHED PEPTIDE THAT LINKS THE CARBOXYL TERMINUS OF PROTEINS TO THE CELL WALL

    Hung Ton-That;Kym F. Faull;Olaf Schneewind

  • The molecular switch that activates the cell wall anchoring step of pilus assembly in gram-positive bacteria

    Anjali Mandlik;Asis Das;Hung Ton-That

  • Anchoring of surface proteins to the cell wall of Staphylococcus aureus. A conserved arginine residue is required for efficient catalysis of sortase A.

    Luciano A. Marraffini;Hung Ton-That;Yinong Zong;Sthanam V.L. Narayana

Frequent Co-Authors

Olaf Schneewind
Olaf Schneewind University of Chicago
Andrzej Joachimiak
Andrzej Joachimiak Argonne National Laboratory
Robert T. Clubb
Robert T. Clubb University of California, Los Angeles
Sarkis K. Mazmanian
Sarkis K. Mazmanian California Institute of Technology
Kym F. Faull
Kym F. Faull University of California, Los Angeles
Michael R. Sawaya
Michael R. Sawaya University of California, Los Angeles
Edward N. Baker
Edward N. Baker University of Auckland
Luciano A. Marraffini
Luciano A. Marraffini Rockefeller University
Cesar A. Arias
Cesar A. Arias The University of Texas Health Science Center at Houston
Andreas Tauch
Andreas Tauch Bielefeld University

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