World's Best Scientists 2026 revealed!
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Immunology
USA
2026
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Biology and Biochemistry
USA
2025

D-Index & Metrics

Best Scientists

D-Index
165
Citations
99742
World Ranking
1045
National Ranking
619

Immunology

D-Index
163
Citations
99420
World Ranking
71
National Ranking
49

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2020 - Distinguished Fellows of the American Association of Immunologists (AAI)
  • 2019 - National Institutes of Health Director's Pioneer Award
  • 2016 - Member of the National Academy of Sciences
  • 2012 - National Institutes of Health Director's Pioneer Award
  • 2000 - Fellow of the American Academy of Arts and Sciences
  • 1997 - Royal Netherlands Academy of Arts and Sciences
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Hidde L. Ploegh is affiliated with Boston Children's Hospital in the United States. Their scientific work spans multiple disciplines, notably medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. Their research further extends into subfields such as molecular biology, immunology, radiology, nuclear medicine and imaging, infectious diseases, and oncology.

Their primary research topics include monoclonal and polyclonal antibodies research, immunotherapy and immune responses, immune cell function and interaction, T-cell and B-cell immunology, interferon and immune responses, glycosylation and glycoproteins research, and CAR-T cell therapy research.

Frequent coauthors of Hidde L. Ploegh include:

  • Novalia Pishesha
  • Ross W. Cheloha
  • Thibault J. Harmand
  • Mohammad Rashidian
  • Charlotte Wijne

They publish regularly in various scientific venues. The most frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Proceedings of the National Academy of Sciences
  • eLife
  • Nature Communications

Recent publications by Hidde L. Ploegh are:

  • "A guide to antigen processing and presentation", 2022, Nature Reviews. Immunology
  • "Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition", 2020, Cell
  • "Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection", 2021, Nature Immunology
  • "Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections", 2021, Immunity
  • "An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity", 2022, Cell

The scientist has been recognized with several awards including:

  • Distinguished Fellows of the American Association of Immunologists (AAI), 2020
  • National Institutes of Health Director's Pioneer Award, 2019
  • Member of the National Academy of Sciences, 2016
  • National Institutes of Health Director's Pioneer Award, 2012
  • Fellow of the American Academy of Arts and Sciences, 2000
  • Royal Netherlands Academy of Arts and Sciences, 1997
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

    Luke A. Gilbert;Max A. Horlbeck;Britt Adamson;Jacqueline E. Villalta

  • CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

    Jan Hendrik Niess;Stephan Brand;Xiubin Gu;Limor Landsman

  • Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.

    Emmanuel J. H. J. Wiertz;Domenico Tortorella;Matthew Bogyo;Joyce Yu

  • The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

    Emmanuel J.H.J Wiertz;Thomas R Jones;Lei Sun;Matthew Bogyo

  • Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

    Takeshi Maruyama;Stephanie K Dougan;Matthias C Truttmann;Angelina M Bilate

  • Empty MHC class I molecules come out in the cold

    H G Ljunggren;N J Stam;C Ohlén;J J Neefjes

  • Herpes simplex virus turns off the TAP to evade host immunity

    Ann Hill;Pieter Jugovic;lan York;Gustav Russ

  • Viral Subversion of the Immune System

    Domenico Tortorella;Benjamin E. Gewurz;Margo H. Furman;Danny J. Schust

  • Viral Strategies of Immune Evasion

    Hidde L. Ploegh

  • The known unknowns of antigen processing and presentation

    Jatin M. Vyas;Annemarthe G. Van der Veen;Hidde L. Ploegh

  • TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.

    Luc Van Kaer;Luc Van Kaer;Philip G. Ashton-Rickardt;Philip G. Ashton-Rickardt;Hidde L. Ploegh;Susumu Tonegawa;Susumu Tonegawa

  • A membrane protein required for dislocation of misfolded proteins from the ER.

    Brendan N. Lilley;Hidde L. Ploegh

  • A guide to antigen processing and presentation

    Unknown

  • An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

    Sabrina M Lehmann;Christina Krüger;Boyoun Park;Katja Derkow

  • Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments.

    Peter J. Peters;Jacques J. Neefjes;Viola Oorschot;Hidde L. Ploegh

  • UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

    You-Me Kim;Melanie M. Brinkmann;Marie-Eve Paquet;Hidde L. Ploegh

  • Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.

    Terry Nakagawa;Wera Roth;Phillip Wong;Andrew Nelson

  • Multiple Associated Proteins Regulate Proteasome Structure and Function

    David S. Leggett;John Hanna;Anna Borodovsky;Bernat Crosas

  • Sortagging: a versatile method for protein labeling

    Maximilian W Popp;John M Antos;Gijsbert M Grotenbreg;Eric Spooner

  • Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.

    Haim Y Cohen;Siva Lavu;Kevin J Bitterman;Brian Hekking

  • Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.

    Rob A. Gruters;Jacques J. Neefjes;Matthijs Tersmette;Ruud E. Y. de Goede

Frequent Co-Authors

Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Jacques Neefjes
Jacques Neefjes Leiden University Medical Center
Huib Ovaa
Huib Ovaa Leiden University Medical Center
Ton N. M. Schumacher
Ton N. M. Schumacher Antoni van Leeuwenhoek Hospital
Marianne Boes
Marianne Boes Utrecht University
Matthew Bogyo
Matthew Bogyo Stanford University
Jan E. Carette
Jan E. Carette Stanford University
Herman S. Overkleeft
Herman S. Overkleeft Leiden University
Thijn R. Brummelkamp
Thijn R. Brummelkamp Antoni van Leeuwenhoek Hospital

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