H-Index & Metrics Top Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry H-index 147 Citations 80,429 585 World Ranking 85 National Ranking 67

Research.com Recognitions

Awards & Achievements

2020 - Distinguished Fellows of the American Association of Immunologists (AAI)

2019 - National Institutes of Health Director's Pioneer Award

2016 - Member of the National Academy of Sciences

2012 - National Institutes of Health Director's Pioneer Award

2000 - Fellow of the American Academy of Arts and Sciences

1997 - Royal Netherlands Academy of Arts and Sciences

Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His primary areas of study are Biochemistry, Cell biology, MHC class I, Antigen presentation and Major histocompatibility complex. His Biochemistry study focuses mostly on Proteasome, Endoplasmic reticulum, Peptide, Ubiquitin and Proteases. His Cell biology study integrates concerns from other disciplines, such as Autophagy, Receptor and UNC93B1.

The study incorporates disciplines such as MHC class II and Virology in addition to MHC class I. The various areas that Hidde L. Ploegh examines in his Antigen presentation study include Molecular biology and Antigen. His work investigates the relationship between Major histocompatibility complex and topics such as Transcription factor that intersect with problems in Tripeptidyl peptidase II and Cell growth.

His most cited work include:

  • Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation (1418 citations)
  • CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance (1302 citations)
  • Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. (1030 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Biochemistry, Cell biology, Major histocompatibility complex, Molecular biology and Antigen. His research in Cell biology intersects with topics in Receptor, Immune system and Antigen-presenting cell. His MHC class I and Transporter associated with antigen processing investigations are all subjects of Major histocompatibility complex research.

Many of his studies on MHC class I involve topics that are commonly interrelated, such as Antigen presentation. His studies in Molecular biology integrate themes in fields like Human leukocyte antigen and Monoclonal antibody. His studies deal with areas such as Antibody and Virology as well as Antigen.

He most often published in these fields:

  • Biochemistry (31.99%)
  • Cell biology (30.47%)
  • Major histocompatibility complex (20.78%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cell biology (30.47%)
  • Antibody (9.83%)
  • Antigen (17.59%)

In recent papers he was focusing on the following fields of study:

His main research concerns Cell biology, Antibody, Antigen, Biochemistry and Immunology. As part of his studies on Cell biology, he often connects relevant areas like Adenylylation. His Antigen research includes elements of Cytotoxic T cell, Molecular biology and T cell, Immune system.

His Cytotoxic T cell research is multidisciplinary, incorporating perspectives in CD8 and Virology. His work in the fields of Biochemistry, such as Membrane protein and Enzyme, intersects with other areas such as Sortase A. His work deals with themes such as Peptide sequence and Peptide, which intersect with Major histocompatibility complex.

Between 2014 and 2021, his most popular works were:

  • Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining (728 citations)
  • CEACAM1 regulates TIM-3-mediated tolerance and exhaustion (286 citations)
  • Structural basis for chemokine recognition and activation of a viral G protein–coupled receptor (196 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

His scientific interests lie mostly in Antibody, Cell biology, Cancer research, CD8 and Biochemistry. His Antibody study combines topics from a wide range of disciplines, such as Cytotoxic T cell and Immune system, Major histocompatibility complex, Antigen. His work carried out in the field of Cell biology brings together such families of science as Pyrin domain, Inflammasome, Adenylylation, Activator and Cytotoxicity.

His CD8 study is related to the wider topic of Immunology. His Biochemistry research includes themes of Biophysics and Chromatography. His studies examine the connections between Monoclonal antibody and genetics, as well as such issues in Internalization, with regards to Molecular biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Top Publications

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

Luke A. Gilbert;Max A. Horlbeck;Britt Adamson;Jacqueline E. Villalta.
Cell (2014)

1695 Citations

CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

Jan Hendrik Niess;Stephan Brand;Xiubin Gu;Limor Landsman.
Science (2005)

1638 Citations

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.

Emmanuel J. H. J. Wiertz;Domenico Tortorella;Matthew Bogyo;Joyce Yu.
Nature (1996)

1387 Citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

Emmanuel J.H.J Wiertz;Thomas R Jones;Lei Sun;Matthew Bogyo.
Cell (1996)

1315 Citations

Herpes simplex virus turns off the TAP to evade host immunity

Ann Hill;Pieter Jugovic;lan York;Gustav Russ.
Nature (1995)

1051 Citations

Viral Subversion of the Immune System

Domenico Tortorella;Benjamin E. Gewurz;Margo H. Furman;Danny J. Schust.
Annual Review of Immunology (2000)

997 Citations

Viral Strategies of Immune Evasion

Hidde L. Ploegh.
Science (1998)

985 Citations

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

Takeshi Maruyama;Stephanie K Dougan;Matthias C Truttmann;Angelina M Bilate.
Nature Biotechnology (2015)

968 Citations

A membrane protein required for dislocation of misfolded proteins from the ER.

Brendan N. Lilley;Hidde L. Ploegh.
Nature (2004)

806 Citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments.

Peter J. Peters;Jacques J. Neefjes;Viola Oorschot;Hidde L. Ploegh.
Nature (1991)

798 Citations

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking h-index is inferred from publications deemed to belong to the considered discipline.

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