What is he best known for?
The fields of study he is best known for:
Emmanuel J. H. J. Wiertz focuses on Endoplasmic reticulum, MHC class I, Cell biology, Virology and Transporter associated with antigen processing.
His Endoplasmic reticulum study is associated with Biochemistry.
His MHC class I study contributes to a more complete understanding of Gene.
His Virology study combines topics in areas such as CD8, Antigen and Antigen presentation.
The CD8 study combines topics in areas such as Cytotoxic T cell, Major histocompatibility complex and T cell.
His Transporter associated with antigen processing research incorporates themes from Molecular biology, Antigen processing, Peptide transport and Gene product.
His most cited work include:
- Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. (1030 citations)
- The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol (987 citations)
- The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. (416 citations)
What are the main themes of his work throughout his whole career to date?
His primary scientific interests are in MHC class I, Virology, Cell biology, Antigen presentation and Transporter associated with antigen processing.
His research on MHC class I frequently links to adjacent areas such as Peptide transport.
His Virology research includes themes of Human leukocyte antigen, Immune system and Cowpox virus.
The concepts of his Cell biology study are interwoven with issues in In vitro and Signal peptide.
Emmanuel J. H. J. Wiertz works mostly in the field of Antigen presentation, limiting it down to topics relating to Antigen and, in certain cases, Antigen-presenting cell.
His work carried out in the field of Transporter associated with antigen processing brings together such families of science as Tapasin, Gene product, Viral protein and Transmembrane domain.
He most often published in these fields:
- MHC class I (54.79%)
- Virology (54.11%)
- Cell biology (43.84%)
What were the highlights of his more recent work (between 2016-2021)?
- Cell biology (43.84%)
- Virology (54.11%)
- MHC class I (54.79%)
In recent papers he was focusing on the following fields of study:
Emmanuel J. H. J. Wiertz spends much of his time researching Cell biology, Virology, MHC class I, Virus and CRISPR.
In the field of Cell biology, his study on Endoplasmic reticulum and Endoplasmic-reticulum-associated protein degradation overlaps with subjects such as SEC62.
In his research, Tropism is intimately related to Vaccinia, which falls under the overarching field of Virology.
His work in MHC class I tackles topics such as Antigen presentation which are related to areas like Major histocompatibility complex.
His Virus research is multidisciplinary, incorporating perspectives in Spleen and Cowpox virus.
The study incorporates disciplines such as Antigen processing and Peptide transport in addition to MHC class I antigen.
Between 2016 and 2021, his most popular works were:
- A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape (66 citations)
- EBV MicroRNA BART16 Suppresses Type I IFN Signaling. (42 citations)
- Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation. (14 citations)
In his most recent research, the most cited papers focused on:
The scientist’s investigation covers issues in Cell biology, Immune system, MHC class I, Antigen presentation and Viral replication.
His Cell biology research is mostly focused on the topic Endoplasmic reticulum.
His study brings together the fields of Ubiquitin and Endoplasmic reticulum.
His study involves TAP1, MHC class I antigen and Transporter associated with antigen processing, a branch of Immune system.
His study in MHC class I is interdisciplinary in nature, drawing from both Transporter and Peptide.
His Viral replication study combines Virus and Virology studies.
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