Emmanuel J. H. J. Wiertz

Overview

Best Publications

• Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.

  Emmanuel J. H. J. Wiertz;Domenico Tortorella;Matthew Bogyo;Joyce Yu

  1443
  Citations

• The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

  Emmanuel J.H.J Wiertz;Thomas R Jones;Lei Sun;Matthew Bogyo

  1395
  Citations

• The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP.

  Kwangseog Ahn;Albrecht Gruhler;Begona Galocha;Thomas R Jones

  679
  Citations

• Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains

  Thomas R. Jones;Emmanuel J. H. J. Wiertz;Lei Sun;Kenneth N. Fish

  575
  Citations

• Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.

  Marjolein Kikkert;Ram Doolman;Min Dai;Rachel Avner

  517
  Citations

• Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

  Yihong Ye;Yoko Shibata;Marjolein Kikkert;Sjaak van Voorden

  458
  Citations

• Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3.

  Xiaoli Wang;Roger A. Herr;Wei Jen Chua;Lonnie Lybarger

  380
  Citations

• Viral immune evasion: a masterpiece of evolution.

  Mireille T M Vossen;Ellen M Westerhout;Cécilia Söderberg-Nauclér;Emmanuel J H J Wiertz

  358
  Citations

• CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections.

  Ferdy R. van Diemen;Elisabeth M. Kruse;Marjolein J. G. Hooykaas;Carlijn E. Bruggeling

  335
  Citations

• Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion.

  Martin Rowe;Britt Glaunsinger;Daphne van Leeuwen;Jianmin Zuo

  288
  Citations

• The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway.

  Andrea Schulze;Sybille Standera;Elke Buerger;Marjolein Kikkert

  286
  Citations

• Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing

  Danijela Koppers-Lalic;Eric A. J. Reits;Maaike E. Ressing;Andrea D. Lipinska

  257
  Citations

• The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation

  Jianmin Zuo;Andrew Currin;Bryan D. Griffin;Claire Shannon-Lowe

  233
  Citations

• A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates.

  Andrew D. Hislop;Maaike E. Ressing;Daphne van Leeuwen;Victoria A. Pudney

  226
  Citations

• TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum.

  Gerco Hassink;Marjolein Kikkert;Sjaak Van Voorden;Shiow Ju Lee

  212
  Citations

• Biosafety assessment of probiotics used for human consumption: recommendations from the EU-PROSAFE project

  Vanessa Vankerckhoven;Vanessa Vankerckhoven;Geert Huys;Marc Vancanneyt;Carl Vael

  205
  Citations

• The HCMV Gene Products US11 and US2 Differ in Their Ability to Attack Allelic Forms of Murine Major Histocompatibility Complex (MHC) Class I Heavy Chains

  Robert P. Machold;Emmanuel J.H.J. Wiertz;Thomas R. Jones;H.L. Ploegh

  200
  Citations

• Immune evasion by human cytomegalovirus: lessons in immunology and cell biology

  Wil A.M Loenen;C.A Bruggeman;E.J.H.J Wiertz

  178
  Citations

• The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

  Helen R. Stagg;Mair Thomas;Dick van den Boomen;Emmanuel J.H.J. Wiertz

  174
  Citations

• Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.

  Maaike E. Ressing;Daniëlle Horst;Bryan D. Griffin;Judy Tellam

  163
  Citations

• Herpesviruses and immunity: the art of evasion.

  Bryan D. Griffin;Marieke C. Verweij;Emmanuel J.H.J. Wiertz;Emmanuel J.H.J. Wiertz

  149
  Citations