World's Best Scientists 2026 revealed!

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Molecular Biology

D-Index
131
Citations
57480
World Ranking
185
National Ranking
116

Biology and Biochemistry

D-Index
135
Citations
58924
World Ranking
354
National Ranking
237

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2005 - Member of the National Academy of Sciences
  • 2005 - Fellow of the American Academy of Arts and Sciences
  • 2003 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Biochemistry and Biophysics
  • 1993 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Tom A. Rapoport is affiliated with Harvard University in the United States and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology and Cell Biology subfields. Their research encompasses a range of topics including Endoplasmic Reticulum Stress and Disease, Ubiquitin and proteasome pathways, Peroxisome Proliferator-Activated Receptors, Autophagy in Disease and Therapy, Cellular transport and secretion, RNA Research and Splicing, as well as RNA modifications and cancer.

Their recent publications reflect diverse investigations within these areas. Notable papers include:

  • Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex, 2020, Science
  • Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies), 2021, Proceedings of the National Academy of Sciences
  • Mechanism of membrane-curvature generation by ER-tubule shaping proteins, 2021, Nature Communications
  • Ddi1 is a ubiquitin-dependent protease, 2020, Proceedings of the National Academy of Sciences
  • Translocation of Proteins through a Distorted Lipid Bilayer, 2021, Trends in Cell Biology

Tom A. Rapoport frequently collaborates with a group of researchers, including Michael L. Skowyra, Navdar Sever, Xudong Wu, Steven P. Gygi, and João A. Paulo. These collaborations have contributed to a significant body of work over the years.

Their work has been published in a variety of scientific venues, predominately in journals and platforms such as:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Nature Communications
  • Harvard SBGrid

Best Publications

  • A Linear Steady‐State Treatment of Enzymatic Chains

    Reinhart Heinrich;Tom A. Rapoport

  • The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

    Yihong Ye;Hemmo H. Meyer;Tom A. Rapoport

  • A Class of Membrane Proteins Shaping the Tubular Endoplasmic Reticulum

    Gia K. Voeltz;William A. Prinz;Yoko Shibata;Julia M. Rist

  • X-ray structure of a protein-conducting channel

    Bert van den Berg;William M. Clemons;Ian Collinson;Yorgo Modis

  • Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.

    Emmanuel J. H. J. Wiertz;Domenico Tortorella;Matthew Bogyo;Joyce Yu

  • Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes

    Tom A. Rapoport

  • A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

    Yihong Ye;Yoko Shibata;Chi Yun;David Ron

  • Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

    Yihong Ye;Hemmo H. Meyer;Tom A. Rapoport

  • Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins.

    Pedro Carvalho;Veit Goder;Tom A. Rapoport

  • Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane

    Dirk Görlich;Tom A. Rapoport

  • PROTEIN TRANSPORT ACROSS THE EUKARYOTIC ENDOPLASMIC RETICULUM AND BACTERIAL INNER MEMBRANES

    Tom A. Rapoport;Berit Jungnickel;Ulrike Kutay

  • Predicting the orientation of eukaryotic membrane-spanning proteins

    Enno Hartmann;Tom A. Rapoport;Harvey F. Lodish

  • Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

    Billy Tsai;Yihong Ye;Tom A. Rapoport

  • Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules.

    Kristen J. Verhey;Debra Meyer;Reneé Deehan;John Blenis

  • METABOLIC REGULATION AND MATHEMATICAL MODELS

    R. Heinrich;S.M. Rapoport;T.A. Rapoport

  • Mathematical models of protein kinase signal transduction.

    Reinhart Heinrich;Benjamin G. Neel;Tom A. Rapoport

  • Structural organization of the endoplasmic reticulum

    Gia K Voeltz;Melissa M Rolls;Tom A Rapoport

  • A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

    Dirk Görlich;Siegfried Prehn;Enno Hartmann;Kai-Uwe Kalies

  • Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin.

    Billy Tsai;Chiara Rodighiero;Wayne I. Lencer;Tom A. Rapoport

  • partners transport proteins from the ER into the cytosol

    Yihong Ye;Hemmo H. Meyer;Tom A. Rapoport

Frequent Co-Authors

Enno Hartmann
Enno Hartmann University of Lübeck
Martin Wiedmann
Martin Wiedmann Cornell University
Reinhart Heinrich
Reinhart Heinrich Humboldt-Universität zu Berlin
Dirk Görlich
Dirk Görlich Max Planck Society
Kathrin Plath
Kathrin Plath University of California, Los Angeles
Teymuras V. Kurzchalia
Teymuras V. Kurzchalia Max Planck Society
Bernhard Dobberstein
Bernhard Dobberstein Heidelberg University
William A. Prinz
William A. Prinz The University of Texas Southwestern Medical Center
Walther Mothes
Walther Mothes Yale University
Wayne I. Lencer
Wayne I. Lencer Harvard University

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