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Biology and Biochemistry

D-Index
88
Citations
20698
World Ranking
2759
National Ranking
201

Research.com Recognitions

  • 2016 - Fellow of the Royal Society, United Kingdom

Overview

Ramanujan S. Hegde is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to molecular biology, cell biology, genetics, epidemiology, and materials chemistry.

Their work covers a variety of topics, including:

  • RNA and protein synthesis mechanisms
  • Bacterial genetics and biotechnology
  • Endoplasmic reticulum stress and disease
  • Cellular transport and secretion
  • RNA research and splicing
  • Ubiquitin and proteasome pathways
  • RNA modifications and cancer

Ramanujan S. Hegde has published extensively, with a notable presence in key venues such as bioRxiv (Cold Spring Harbor Laboratory), Molecular Cell, eLife, Science, and Nature. The counts of publications include nine in bioRxiv, eight in Molecular Cell, four each in eLife and Science, and three in Nature.

Recent papers authored or coauthored by Ramanujan S. Hegde include:

  • The mechanisms of integral membrane protein biogenesis, 2021, Nature Reviews Molecular Cell Biology
  • The ASC-1 Complex Disassembles Collided Ribosomes, 2020, Molecular Cell
  • Ribosome collisions trigger cis-acting feedback inhibition of translation initiation, 2020, eLife
  • Mechanism of an intramembrane chaperone for multipass membrane proteins, 2022, Nature
  • The architecture of EMC reveals a path for membrane protein insertion, 2020, eLife

Frequent coauthors collaborating with Ramanujan S. Hegde include:

  • Robert J. Keenan (10 joint publications)
  • Szymon Juszkiewicz (8 joint publications)
  • Sew-Yeu Peak-Chew (6 joint publications)
  • Aaron J. O. Lewis (6 joint publications)
  • Eszter Zavodszky (6 joint publications)

Ramanujan S. Hegde was awarded the Fellowship of the Royal Society, United Kingdom, in 2016.

Best Publications

  • A transmembrane form of the prion protein in neurodegenerative disease.

    Ramanujan S. Hegde;James A. Mastrianni;Michael R. Scott;Kathryn A. DeFea

  • The surprising complexity of signal sequences.

    Ramanujan S. Hegde;Harris D. Bernstein

  • Identification of a Targeting Factor for Posttranslational Membrane Protein Insertion into the ER

    Sandra Stefanovic;Ramanujan S. Hegde

  • Formation of stacked ER cisternae by low affinity protein interactions

    Erik L. Snapp;Ramanujan S. Hegde;Maura Francolini;Francesca Lombardo

  • Regulation of basal cellular physiology by the homeostatic unfolded protein response

    D. Thomas Rutkowski;Ramanujan S. Hegde

  • Transmissible and genetic prion diseases share a common pathway of neurodegeneration

    Ramanujan S. Hegde;Patrick Tremblay;Darlene Groth;Stephen J. DeArmond

  • Ribosome-associated protein quality control.

    Onn Brandman;Ramanujan S Hegde

  • Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination

    Szymon Juszkiewicz;Ramanujan S. Hegde

  • Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

    Rebecca M. Voorhees;Israel S. Fernández;Sjors H.W. Scheres;Ramanujan S. Hegde

  • Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane

    Ryen D. Fons;Brigitte A. Bogert;Ramanujan S. Hegde

  • ZNF598 Is a Quality Control Sensor of Collided Ribosomes.

    Szymon Juszkiewicz;Viswanathan Chandrasekaran;Zhewang Lin;Sebastian Kraatz

  • Tail-anchored membrane protein insertion into the endoplasmic reticulum

    Ramanujan S. Hegde;Robert J. Keenan

  • Membrane protein insertion at the endoplasmic reticulum.

    Sichen Shao;Ramanujan S. Hegde

  • Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.

    Sang Wook Kang;Neena S. Rane;Soo Jung Kim;Jennifer L. Garrison

  • Structural basis for stop codon recognition in eukaryotes.

    Alan Brown;Sichen Shao;Jason Murray;Ramanujan S. Hegde

  • A ribosome-associating factor chaperones tail-anchored membrane proteins

    Malaiyalam Mariappan;Xingzhe Li;Xingzhe Li;Sandra Stefanovic;Ajay Sharma

  • The ER membrane protein complex is a transmembrane domain insertase

    Alina Guna;Norbert Volkmar;John C. Christianson;Ramanujan S. Hegde

  • Protein targeting and degradation are coupled for elimination of mislocalized proteins

    Tara Hessa;Ajay Sharma;Malaiyalam Mariappan;Heather D. Eshleman;Heather D. Eshleman

  • A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation

    Qiuyan Wang;Yanfen Liu;Nia Soetandyo;Kheewoong Baek

  • Structure of the Sec61 channel opened by a signal sequence

    Rebecca M. Voorhees;Ramanujan S. Hegde

Frequent Co-Authors

Jack Taunton
Jack Taunton University of California, San Francisco
Venki Ramakrishnan
Venki Ramakrishnan MRC Laboratory of Molecular Biology
Robert J. Keenan
Robert J. Keenan University of Chicago
Stephen J. DeArmond
Stephen J. DeArmond University of California, San Francisco
Stanley B. Prusiner
Stanley B. Prusiner University of California, San Francisco
Tom A. Rapoport
Tom A. Rapoport Harvard University
Jennifer Lippincott-Schwartz
Jennifer Lippincott-Schwartz Howard Hughes Medical Institute
Indu S. Ambudkar
Indu S. Ambudkar National Institutes of Health
Darlene Groth
Darlene Groth University of California, San Francisco
Susan E. Bates
Susan E. Bates Columbia University

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