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Medicine

D-Index
93
Citations
24566
World Ranking
11034
National Ranking
5680

Overview

Robert J. Keenan is affiliated with the University of Chicago in the United States. Their research primarily falls within Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology, Rheumatology, Cell Biology, Genetics, and Structural Biology as sub-disciplines.

Their research topics cover several key areas including:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • Rheumatoid Arthritis Research and Therapies
  • Bacterial Genetics and Biotechnology
  • Advanced Electron Microscopy Techniques and Applications
  • Endoplasmic Reticulum Stress and Disease
  • Cellular transport and secretion

Recent publications reflect these research interests with notable papers such as:

  • The mechanisms of integral membrane protein biogenesis (2021, Nature Reviews Molecular Cell Biology)
  • An ER translocon for multi-pass membrane protein biogenesis (2020, eLife)
  • Mechanism of an intramembrane chaperone for multipass membrane proteins (2022, Nature)
  • The architecture of EMC reveals a path for membrane protein insertion (2020, eLife)
  • Substrate-driven assembly of a translocon for multipass membrane proteins (2022, Nature)

The frequent co-authors who have collaborated extensively with Keenan include Ramanujan S. Hegde, Kelli D. Allen, Todd A. Schwartz, Amr H. Sawalha, and Susan A. Boackle. These partnerships indicate ongoing research collaborations in overlapping or complementary scientific domains.

The most common publication venues for Keenan's work are:

  • Arthritis Care & Research
  • eLife
  • Nature
  • Nature Structural & Molecular Biology
  • bioRxiv (Cold Spring Harbor Laboratory)

Robert J. Keenan's profile demonstrates a multidisciplinary approach centered on molecular mechanisms related to protein biogenesis, cell biology, and disease states including rheumatoid arthritis and cancer. The concentration on integral and multipass membrane proteins is reflected in many recent high-impact publications, indicating a detailed exploration of protein synthesis and cellular transport processes.

Best Publications

  • The Signal Recognition Particle

    Robert J. Keenan;Douglas M. Freymann;Robert M. Stroud;Peter Walter

  • Postoperative pain-related morbidity: video-assisted thoracic surgery versus thoracotomy.

    Rodney J. Landreneau;Stephen R. Hazelrigg;Michael J. Mack;Robert D. Dowling

  • Physiologic Evaluation of the Patient With Lung Cancer Being Considered for Resectional Surgery: ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition)

    Gene L. Colice;Shirin Shafazand;John P. Griffin;Robert Keenan

  • Improvement in pulmonary function and elastic recoil after lung reduction surgery for diffuse emphysema

    F. C. Sciurba;R. M. Rogers;R. J. Keenan;W. A. Slivka

  • Obliterative bronchiolitis after lung and heart-lung transplantation: An analysis of risk factors and management

    Ko Bando;Irvin L. Paradis;Shari Similo;Hiroaki Konishi

  • Prevalence of chronic pain after pulmonary resection by thoracotomy or video-assisted thoracic surgery.

    Rodney J. Landreneau;Michael J. Mack;Stephen R. Hazelrigg;Keith Naunheim

  • Segmental resection spares pulmonary function in patients with stage I lung cancer

    Robert J Keenan;Rodney J Landreneau;Richard H Maley;Deepak Singh

  • Wedge resection versus lobectomy for stage I (T1 N0 M0) non-small-cell lung cancer

    Rodney J. Landreneau;David J. Sugarbaker;Michael J. Mack;Stephen R. Hazelrigg

  • Perioperative mortality and morbidity after sublobar versus lobar resection for early-stage non-small-cell lung cancer: post-hoc analysis of an international, randomised, phase 3 trial (CALGB/Alliance 140503).

    Nasser K Altorki;Xiaofei Wang;Dennis Wigle;Lin Gu

  • Minimally invasive esophagectomy

    James D Luketich;Philip R Schauer;Neil A Christie;Tracey L Weigel

  • Crystal Structure of the Signal Sequence Binding Subunit of the Signal Recognition Particle

    Robert J Keenan;Douglas M Freymann;Peter Walter;Robert M Stroud

  • Tail-anchored membrane protein insertion into the endoplasmic reticulum

    Ramanujan S. Hegde;Robert J. Keenan

  • Evaluation of distant metastases in esophageal cancer: 100 consecutive positron emission tomography scans.

    J D Luketich;D M Friedman;T L Weigel;M A Meehan

  • A ribosome-associating factor chaperones tail-anchored membrane proteins

    Malaiyalam Mariappan;Xingzhe Li;Xingzhe Li;Sandra Stefanovic;Ajay Sharma

  • Thoracoscopy for empyema and hemothorax.

    Rodney J. Landreneau;Robert J. Keenan;Stephen R. Hazelrigg;Michael J. Mack

  • Laparoscopic Repair of Giant Paraesophageal Hernia: 100 Consecutive Cases

    James D. Luketich;Siva Raja;Hiran C. Fernando;William Campbell

  • Laboratory-Directed Protein Evolution

    Ling Yuan;Itzhak Kurek;James English;Robert Keenan

  • Unilateral thoracoscopic surgical approach for diffuse emphysema.

    Robert J. Keenan;Rodney J. Landreneau;Frank C. Sciurba;Peter F. Ferson

  • Cytomegalovirus serologic status and postoperative infection correlated with risk of developing chronic rejection after pulmonary transplantation.

    Keenan Rj;Lega Me;Dummer Js;Paradis Il

  • International guidelines for the selection of lung transplant candidates

    Robert Aris;Richard G. Barbers;Robyn Barst;Maher A. Baz

Frequent Co-Authors

Rodney J. Landreneau
Rodney J. Landreneau University of Pittsburgh
James D. Luketich
James D. Luketich University of Pittsburgh
Robert L. Hardesty
Robert L. Hardesty University of Pittsburgh
Adriana Zeevi
Adriana Zeevi University of Pittsburgh
Kenneth R. McCurry
Kenneth R. McCurry Cleveland Clinic
Ramanujan S. Hegde
Ramanujan S. Hegde MRC Laboratory of Molecular Biology
Frank C. Sciurba
Frank C. Sciurba University of Pittsburgh
Robert L. Kormos
Robert L. Kormos University of Pittsburgh
Peter Walter
Peter Walter University of California, San Francisco
Benjamin S. Glick
Benjamin S. Glick University of Chicago

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